Rapid detection of regionally clustered germ-line BRCA1 mutations by multiplex heteroduplex analysis

American Journal of Human Genetics

Volumn 58, Issue 3, 1996, Pages 451-456

  Gayther, Simon A ^a   Harrington, Patricia ^a   Russell, Paul ^a   Kharkevich, Galina ^b   Garkavtseva, R F ^b   Ponder, Bruce A J ^a   Bishop, D T ^c   Carmichael, J ^c   Collins, W P ^c   Cox, D ^c   Easton, D ^c   Fraser, G R ^c   Lowe, D G ^c   Mackay, J ^c   Shepherd, J H ^c   Steel, C M ^c  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

HETERODUPLEX;

ARTICLE; BREAST CARCINOMA; CANCER SUSCEPTIBILITY; FEMALE; GENE ISOLATION; GENE MUTATION; GENETIC SCREENING; GERM LINE; HUMAN; MAJOR CLINICAL STUDY; OVARY CARCINOMA; PRIORITY JOURNAL;

BASE SEQUENCE; BRCA1 PROTEIN; BREAST NEOPLASMS; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; EXONS; FEMALE; GENETIC SCREENING; GERM-LINE MUTATION; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; NUCLEIC ACID HETERODUPLEXES; OVARIAN NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 19144367118     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Castilla L, Couch FJ, Erdos MR, Hoskins AF, Calzone K, Garber JE, Boyd J, et al (1994) Mutations in the BRCA1 in families with early onset breast and ovarian cancer. Nat Genet 8:387-391
2. Dunning AM, Renges H-H, Xu C-F, Peacock R, Brasseur R, Laxer G, Tikkanen MJ, et al (1992) Two amino acid substitutions in apolipoprotein B are in complete allelic association with the antigen group (x/y) polymorphism: evidence for little recombination in the 3′ end of the human gene. Am J Hum Genet 50:208-221
3. Easton DF, Bishop DT, Ford D, Cockford GP, the Breast Cancer Linkage Consortium (1993) Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. Am J Hum Genet 52:678-701
4. Friedman LS, Ostermeyer EA, Szabo CI, Dowd P, Lynch ED, Rowell SE, King M-C (1994) Confirmation of BRCA1 by analysis of germ-line mutations linked to breast and ovarian cancer in ten families. Nat Genet 8:399-404
5. Friend S, the Breast Cancer Information Core Steering Committee (1995) Breast cancer information on the web. Nat Genet 11:238-239