Systemic ondansetron antagonizes the sensory block produced by intrathecal lidocaine

Anesthesia and Analgesia

Volumn 100, Issue 6, 2005, Pages 1817-1821

  Fassoulaki, Argyro ^a,b,d   Melemeni, A ^b   Zotou, Marianna ^b   Sarantopoulos, Constantine ^c  

^a UNIVERSITY OF ATHENS   (Greece)

^b SAINT SAVVAS HOSPITAL   (Greece)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d NONE   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

FENTANYL; LIDOCAINE; NITROUS OXIDE; ONDANSETRON;

ADULT; AGED; ARTICLE; BACKACHE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ANTAGONISM; HUMAN; HYPERBARISM; MAJOR CLINICAL STUDY; MALE; MOTOR NERVE BLOCK; NERVE BLOCK; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPINAL ANESTHESIA; TRANSURETHRAL RESECTION;

EID: 19044398855     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000152616.57107.F6     Document Type: Article

References (16)

1. Fassoulaki A, Sarantopoulos C, Chondreli S. Systemic fentanyl enhances the spread of spinal analgesia produced by lidocaine. Br J Anaesth 1991;67:437-9.
2. Sarantopoulos C, Fassoulaki A. Systemic opioids enhance the spread of sensory analgesia produced by intrathecal lidocaine. Anesth Analg 1994;79:94-7.
3. Fassoulaki A, Sarantopoulos C, Zotou M. Nitrous oxide enhances the level of sensory block produced by intrathecal lidocaine. Anesth Analg 1997;85:1108-11.
4. Ye JH, Mui WC, Ren J, Hunt EE. Ondansetron exhibits the properties of a local anesthetic. Anesth Analg 1997;85:1116-21.
5. Glaum SR, Proudfit HK, Anderson EG. Reversal of the antinociceptive effects of intrathecally administered serotonin in the rat by a selective 5-HT3 receptor antagonist. Neurosci Lett 1988;95:313-7.
6. Morales M, De Wang S. Differential composition of 5-hydroxytryptamine3 receptors synthesized in the rat CNS and peripheral nervous system. J Neurosci 2002;22:6732-41.
7. Fassoulaki A, Zotou M, Sarantopoulos C. Effect of nimodipine on regression of spinal analgesia. Br J Anaesth 1998;81:358-60.
8. Fassoulaki A, Sarantopoulos C, Zotou M, Karabinis G. Assessment of the level of sensory block after subarachnoid anesthesia using a pressure palpator. Anesth Analg 1999;88:398-401.
9. Sandrina M, Vitalea G, Pinib LA. Central antinociceptive activity of acetylsalicylic acid is modulated by brain serotonin receptor subtypes. Pharmacology 2002;65:193-7.
10. Hunt TE, Wu W, Zbuzej VK. Ondansetron blocks nifedipine-induced analgesia in rats. Anesth Analg 1996;82:498-500.
11. Petersen-Felix S, Arendt-Nielsen P, Bak P, et al. Ondansetron does not inhibit the analgesic effect of alfentanil. Br J Anaesth 1994;73:326-30.
12. De Witte JL, Schoenmaekers B, Sessler DL, Deloof T. The analgesic efficacy of tramadol is impaired by concurrent administration of ondansetron. Anesth Analg 2001;92:1319-21.
13. della Rocca M, Romano S, Romano R, et al. Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT3 spinal receptor involvement in acute pain in humans. Anesth Analg 2002;94:1553-7.
14. Alhaider AA, Lei SZ, Wilcox GL. Spinal 5-HT3 receptor mediated antinociception: possible release of GABA. J Neurosci 1991;11:1881-8.
15. Cui M, Feng Y, McAdoo DJ, Willis WD. Periaqueductal gray stimulation-induced inhibition of nociceptive dorsal horn neurons in rats is associated with the release of norepinephrine, serotonin, and aminoacids. J Pharmacol Exp Ther 1999;289:868-76.
16. Naesh O, Hindberg I, Christiansen C. Subarachnoid bupivacaine increases human cerebrospinal fluid concentration of serotonin. Reg Anesth 1996;21:446-50.