Counting the true cost of antiplatelet therapy for stroke prevention

Age and Ageing

Volumn 34, Issue 3, 2005, Pages 212-214

  Morton, James A ^a   Newton, Julia ^b   Gray, Christopher S ^b  

^a SUNDERLAND ROYAL HOSPITAL   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID PLUS DIPYRIDAMOLE; ANTACID AGENT; ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT; CLOPIDOGREL; DIPYRIDAMOLE; GASTROINTESTINAL AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PROTON PUMP INHIBITOR; STEROID;

ARTERY DISEASE; BLEEDING; CEREBROVASCULAR ACCIDENT; CLINICAL TRIAL; COST EFFECTIVENESS ANALYSIS; DIGESTIVE SYSTEM PERFORATION; DRUG COST; DRUG FATALITY; DRUG RELEASE; DYSPEPSIA; GASTROINTESTINAL HEMORRHAGE; GASTROINTESTINAL SYMPTOM; HELICOBACTER INFECTION; HIGH RISK PATIENT; HUMAN; LOW DRUG DOSE; NOTE; PEPTIC ULCER; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRACTICE GUIDELINE; PRIORITY JOURNAL; STOMACH ULCER; STROKE; TRANSIENT ISCHEMIC ATTACK;

AGED; ASPIRIN; CEREBROVASCULAR ACCIDENT; COST-BENEFIT ANALYSIS; DIPYRIDAMOLE; DRUG COMBINATIONS; FEMALE; GASTROINTESTINAL DISEASES; GREAT BRITAIN; HUMANS; MALE; PLATELET AGGREGATION INHIBITORS; RECURRENCE; TICLOPIDINE;

HELICOBACTER;

EID: 19044398504     PISSN: 00020729     EISSN: None     Source Type: Journal    
DOI: 10.1093/ageing/afi072     Document Type: Note

References (18)

1. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high-risk patients. BMJ 2002; 324: 71-86.
2. Final Appraisal Determination. Clopidogrel and modified-release dipyridamole in the prevention of occlusive vascular events. NICE. http://www.nice.org.uk/pdf/FAD_Clopdip_Vascular.pdf. Accessed 12/11/2004.
3. From emims. http://www.emims.net. Accessed 25/06/2004.
4. CAST (Chinese Acute Stroke Trial) Collaborative Group. CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischaemic stroke. Lancet 1997; 349: 1641-9.
5. International Stroke Trial Collaborative Group. The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both or neither among 19435 patients with acute ischaemic stroke. Lancet 1997; 349: 1569-81.
6. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 1996; 348: 1329-39.
7. Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A. European Stroke Prevention Study 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 1996; 143: 1-13.
8. Diener HC, Bogousslavsky J, Brass LM et al. MATCH investigators. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 2004; 364: 331-7.
9. Roderick PJ, Wilkes HC, Meade TW. The gastrointestinal toxicity of aspirin: an overview of randomised controlled trials. Br J Clin Pharmacol 1993; 35: 219-26.
10. Cryer B, Feldman M. Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humans. Gastroenterology 1999; 117: 17-25.
11. Laine L. Approaches to non-steroidal and-inflammatory drug use in the high-risk patient. Gastroenterology 2001; 120: 594-606.
12. Peterson WL. Helicobacter pylori and peptic ulcer disease. N Engl J Med 1991; 324: 1043-8.
13. Yeomans N, Hawkey C, Lanas A, Naesdal J, Talley N, Thomson A. Prevalence of gastric and duodenal ulcers during treatment with 'low dose' aspirin. Gastroenterology 2002; 122: A-87(Abstract 701).
14. Aalykke C, Lauritsen JM, Hallas J et al. Helicobacter pylori and risk of ulcer bleeding among users of non-steroidal anti-inflammatory drugs: a case control study. Gastroenterology 1999; 116: 1305-9.
15. Papatheodoridis GV, Papadelli D, Cholongitas E et al. Effect of Helicobacter pylori infection on the risk of upper gastrointestinal bleeding in users of non-steroidal anti-inflammatory drugs. Am J Med 2004; 116: 601-5.
16. Lai KC, Lam SK, Chu KM et al. Lansoprazole for the prevention of recurrences of ulcer complications from long-term low dose aspirin use. N Engl J Med 2002; 346: 2033-8.
17. Moayyedi P, Carter AM, Braunholz D, Catto AJ. Helicobacter pylori infection in subjects with acute ischaemic stroke. Dig Liver Dis 2003; 35: 16-9.
18. Newton JL, Johns CE, May FEB. The ageing bowel and intolerance to aspirin. Aliment Pharmacol Ther 2004; 19: 39-45.