Ventricularization of atrial gene expression in the fibrillating heart?

Circulation Research

Volumn 96, Issue 9, 2005, Pages 923-924

  Tomaselli, Gordon F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arrhythmia; Atrial fibrillation; Calcium handling; Metabolism; Microarray; Potassium channels; RNA; Transcription

Indexed keywords

ANTIARRHYTHMIC AGENT;

CALCIUM HOMEOSTASIS; DISEASE COURSE; DISEASE PREDISPOSITION; DNA MICROARRAY; EDITORIAL; ELECTROPHYSIOLOGY; ENERGY METABOLISM; FIBROSIS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART LEFT VENTRICLE; HEART MUSCLE; HEART RIGHT ATRIUM; HEMODYNAMICS; HUMAN; MITRAL VALVE REGURGITATION; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SINUS RHYTHM; TRICUSPID VALVE DISEASE;

ATRIAL FIBRILLATION; GENE EXPRESSION PROFILING; HEART ATRIA; HEART VENTRICLES; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TRANSCRIPTION, GENETIC;

EID: 19044397870     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000168041.46134.8e     Document Type: Editorial

References (12)

1. Barth AS, Merk S, Arnoldi E, Zwermann L, Kloos P, Gebauer M, Steinmeyer K, Bleich M, Kääb S, Hinterseer M, Kartmann H, Kreuzer E, Dugas M, Steinbeck G, Nabauer M. Reprogramming of the human atrial transcriptome in permanent atrial fibrillation. Expression of a ventricular-like genomic signature. Circ Res. 2005;96:1022-1029.
2. Van Wagoner DR, Pond AL, McCarthy PM, Trimmer JS, Nerbonne JM. Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ Res. 1997;80:772-781.
3. Van Wagoner DR, Pond AL, Lamorgese M, Rossie SS, McCarthy PM, Nerbonne JM. Atrial L-type Ca2+ currents and human atrial fibrillation [see comments]. Circ Res. 1999;85:428-436.
4. Nattel S. New ideas about atria] fibrillation 50 years on. Nature. 2002;415:219-226.
5. Nattel S, Shiroshita-Takeshita A, Cardin S, Pelletier P. Mechanisms of atrial remodeling and clinical relevance. Curr Opin Cardiol. 2005;20:21-25.
6. Corradi D, Callegari S, Benussi S, Nascimbene S, Pastori P, Calvi S, Maestri R, Astorri E, Pappone C, Alfieri O. Regional left atrial interstitial remodeling in patients with chronic atrial fibrillation undergoing mitral-valve surgery. Virchows Arch. 2004;445:498-505.
7. Cha TJ, Ehrlich JR, Zhang L, Shi YF, Tardif JC, Leung TK, Nattel S. Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure. Circulation. 2004;109:412-418.
8. Sanders P, Morton JB, Davidson NC, Spence SJ, Vohra JK, Sparks PB, Kalman JM. Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans. Circulation. 2003;108:1461-1468.
9. Wyse DG, Waldo AL, DiMarco JP, Domanski MJ, Rosenberg Y, Schron EB, Kellen JC, Greene HL, Mickel MC, Dalquist JE, Corley SD. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med. 2002;347:1825-1833.
10. Kistler PM, Sanders P, Fynn SP, Stevenson IH, Spence SJ, Vohra JK, Sparks PB, Kalman JM. Electrophysiologic and electroanatomic changes in the human atrium associated with age. J Am Coll Cardiol. 2004;44:109-116.
11. Thijssen VL, van der Velden HM, van Ankeren EP, Ausma J, Allessie MA, Borgers M, van Eys GJ, Jongsma HJ. Analysis of altered gene expression during sustained atrial fibrillation in the goat. Cardiovasc Res. 2002;54:427-437.
12. Lai LP, Lin JL, Lin CS, Yeh HM, Tsay YG, Lee CF, Lee HH, Chang ZF, Hwang JJ, Su MJ, Tseng YZ, Huang SK. Functional genomic study on atrial fibrillation using cDNA microarray and two-dimensional protein electrophoresis techniques and identification of the myosin regulatory light chain isoform reprogramming in atrial fibrillation. J Cardiovasc Electrophysiol. 2004;15:214-223.