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Volumn 19, Issue 3, 1996, Pages 248-250

Synthesis and anticonvulsant evaluation of a series of N-Cbz-α-aminoglutarimides

Author keywords

Anticonvulsant; Glutarimide; Maximal electric shock(MES); Pentylenetetrazole induced seizure(PTZ)

Indexed keywords


EID: 19044395156     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02976901     Document Type: Article
Times cited : (9)

References (15)
  • 1
    • 0027241691 scopus 로고
    • The Synthesis of Novel GABA Uptake Inhibitors. 1. Elucidation of the Structure-Activity Studies Leading to the Choice of (R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (Tiagabine) as an Anticonvulsant Drug Candidate
    • Andersen, K. E., Braestrup, C. B., Gronvald, F. C., Jorgensen, A. S., Nielsen, E. B., Sonnewald, U., Sorensen, P. O., Suzdak, P. D. and Knutsen, L. J. S., The Synthesis of Novel GABA Uptake Inhibitors. 1. Elucidation of the Structure-Activity Studies Leading to the Choice of (R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (Tiagabine) as an Anticonvulsant Drug Candidate, J. Med. Chem., 36, 1716-1725 (1993).
    • (1993) J. Med. Chem. , vol.36 , pp. 1716-1725
    • Andersen, K.E.1    Braestrup, C.B.2    Gronvald, F.C.3    Jorgensen, A.S.4    Nielsen, E.B.5    Sonnewald, U.6    Sorensen, P.O.7    Suzdak, P.D.8    Knutsen, L.J.S.9
  • 2
    • 0023239159 scopus 로고
    • Anticonvulsant Activity of Indanylspirosuccinimide Mannich Bases
    • Bornstein, M. R. and Doukas, P. H., Anticonvulsant Activity of Indanylspirosuccinimide Mannich Bases, J. Pharm. Sci., 76, 300-302 (1987).
    • (1987) J. Pharm. Sci. , vol.76 , pp. 300-302
    • Bornstein, M.R.1    Doukas, P.H.2
  • 3
    • 0028028227 scopus 로고
    • Bicycloc Hydantoins with a Bridgehead Nitrogen, Comparison of Anticonvulsant Activities with Binding to the Neuronal Voltage-Dependent Sodium Channel
    • Brouillette, W. J., Jestkov, V. P., Brown, M. L., Akhatar, M. S., DeLrey, T. M. and Brown, G. B., Bicycloc Hydantoins with a Bridgehead Nitrogen, Comparison of Anticonvulsant Activities with Binding to the Neuronal Voltage-Dependent Sodium Channel, J. Med. Chem., 37, 3289-3293 (1994).
    • (1994) J. Med. Chem. , vol.37 , pp. 3289-3293
    • Brouillette, W.J.1    Jestkov, V.P.2    Brown, M.L.3    Akhatar, M.S.4    DeLrey, T.M.5    Brown, G.B.6
  • 5
    • 0027970096 scopus 로고
    • Substituted 2-Benzothiazolamines as Sodium Flux Inhibitors: Quantitative Structure-Activity Relationships and Anticonvulsant Activity
    • Hays, S. J., Rice, M. J., Ortwine, D. F., Johnson, G., Schwarz, R. D., Boyd, D. K., Coperando, L.F., Vartanian, M. G., and Boxer, P. A., Substituted 2-Benzothiazolamines as Sodium Flux Inhibitors: Quantitative Structure-Activity Relationships and Anticonvulsant Activity, J. Pharm. Sci., 83, 1425-1432 (1994) and references cited therein.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 1425-1432
    • Hays, S.J.1    Rice, M.J.2    Ortwine, D.F.3    Johnson, G.4    Schwarz, R.D.5    Boyd, D.K.6    Coperando, L.F.7    Vartanian, M.G.8    Boxer, P.A.9
  • 6
    • 0027142524 scopus 로고
    • Synthesis and Binding Properties of 2-Amino-5-phosphono-3-pentenoic acid Photoaffinty Ligands as Probes for the Glutamate Recognition Site of the NMDA Receptor
    • Heckendorn, R., Allgeier, H., Baud, J., Gundenhauser, W. and Angst, C., Synthesis and Binding Properties of 2-Amino-5-phosphono-3-pentenoic acid Photoaffinty Ligands as Probes for the Glutamate Recognition Site of the NMDA Receptor. J. Med. Chem., 36, 3721-3726 (1993).
    • (1993) J. Med. Chem. , vol.36 , pp. 3721-3726
    • Heckendorn, R.1    Allgeier, H.2    Baud, J.3    Gundenhauser, W.4    Angst, C.5
  • 7
    • 84984063678 scopus 로고
    • Peptide. 1. Selective protection of a- or Side chain Carboxyl Groups of Aspartic and Glutamic Acid. A Facile Synthesis of β-Aspartyl and γ-Glutamyl Peptides
    • Itoh, M., Peptide. 1. Selective protection of a- or Side chain Carboxyl Groups of Aspartic and Glutamic Acid. A Facile Synthesis of β-Aspartyl and γ-Glutamyl Peptides. Chem. Pharm. Bull., 17, 1679-1686 (1969).
    • (1969) Chem. Pharm. Bull. , vol.17 , pp. 1679-1686
    • Itoh, M.1
  • 8
    • 0028307689 scopus 로고
    • Anticonvulsant Properties of N-substituted α,α-Diamino acid Derivatives
    • Kohn, H., Sawhney, K. N., Robertson, D. W. and Leander, J. D., Anticonvulsant Properties of N-substituted α,α-Diamino acid Derivatives. J. Pharm. Sci., 83, 689-691 (1994).
    • (1994) J. Pharm. Sci. , vol.83 , pp. 689-691
    • Kohn, H.1    Sawhney, K.N.2    Robertson, D.W.3    Leander, J.D.4
  • 9
    • 0027443545 scopus 로고
    • Synthesis and Anticonvulsant Activities of α-Heterocyclic α-Acetamido-N-benzylacetamide Derivatives
    • Kohn, H., Sawhney, K. N., Bardel, P., Robertson, D. W. and Leander, J. D., Synthesis and Anticonvulsant Activities of α-Heterocyclic α-Acetamido-N-benzylacetamide Derivatives. J. Med. Chem., 36, 3350-3360 (1993).
    • (1993) J. Med. Chem. , vol.36 , pp. 3350-3360
    • Kohn, H.1    Sawhney, K.N.2    Bardel, P.3    Robertson, D.W.4    Leander, J.D.5
  • 10
    • 0021358359 scopus 로고
    • Synthesis and Anticonvulsant Evaluation of N-Aminosuccinimides
    • Kornet, M. J. Synthesis and Anticonvulsant Evaluation of N-Aminosuccinimides. J. Pharm. Sci., 73, 405-406 (1984).
    • (1984) J. Pharm. Sci. , vol.73 , pp. 405-406
    • Kornet, M.J.1
  • 11
    • 0026012420 scopus 로고
    • GABA uptake Inhibitors: Construction of a General Pharmacophore Model and Successful Prediction of a New Representative
    • N'Goka, V., Schlewer, G., Linget, J. M., Chambon, J. P. and Wermuth, C. G., GABA uptake Inhibitors: Construction of a General Pharmacophore Model and Successful Prediction of a New Representative., J. Med. Chem., 34, 2547-2557 (1991).
    • (1991) J. Med. Chem. , vol.34 , pp. 2547-2557
    • N'Goka, V.1    Schlewer, G.2    Linget, J.M.3    Chambon, J.P.4    Wermuth, C.G.5
  • 13
    • 0028049798 scopus 로고
    • Srtucture-Activity Study of 5-Substituted 1-Carbobenzoxy-2-iminohydantoins as Potential Anticonvulsant Agents
    • Sun, Z. Y., Kwon, C. H. and Wurpel, N. D., Srtucture-Activity Study of 5-Substituted 1-Carbobenzoxy-2-iminohydantoins as Potential Anticonvulsant Agents. J. Med. Chem., 37, 2841-2845 (1994) and references cited therein.
    • (1994) J. Med. Chem. , vol.37 , pp. 2841-2845
    • Sun, Z.Y.1    Kwon, C.H.2    Wurpel, N.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.