Inhibition of CN (protein phosphatase-2B) suppresses Ca2+- mediated acid secretion in rats

Alimentary Pharmacology and Therapeutics, Supplement

Volumn 16, Issue 2, 2002, Pages 20-28

  Itoh, S ^a   Otaka, M ^a   Odashima, M ^a   Zeniya, A ^b   Okuyama, A ^a   Jin, M ^a   Otani, S ^b   Iwabuchi, A ^a   Sasahara, H ^a   Masamune, O ^a   Watanabe, S ^a  

^a AKITA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Division of Pediatrics Akita Municipal General Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM ION; CARBACHOL; GASTRIN; HISTAMINE; MUSCARINIC M3 RECEPTOR; PROTON PUMP; TACROLIMUS; TETRAGASTRIN; CALCIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INHIBITION; ENZYME INHIBITION; ENZYME LOCALIZATION; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; RAT; SECRETORY CELL; SIGNAL TRANSDUCTION; STIMULUS SECRETION COUPLING; STOMACH ACID SECRETION; STOMACH CHIEF CELL; STOMACH EPITHELIUM; STOMACH MUCOSA; STOMACH PARIETAL CELL; ANIMAL; CHEMICAL PHENOMENA; DRUG ANTAGONISM; MALE; METABOLISM; PHYSIOLOGY; SECRETION; SPRAGUE DAWLEY RAT; STOMACH ACID; STOMACH PH;

ANIMALS; CALCINEURIN; CALCIUM; DEPRESSION, CHEMICAL; GASTRIC ACID; GASTRIC ACIDITY DETERMINATION; GASTRIC MUCOSA; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TACROLIMUS;

EID: 19044384603     PISSN: 09530673     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2036.16.s2.7.x     Document Type: Article

References (32)

1. Hamajima E, Sugiyama S, Hoshino H, Goto H, Tsukamoto Y, Ozawa T. Effects of FK506, an immunosuppressive agent, on genesis of water-immersion stress-induced gastric lesions in rats. Dig Dis Sci 1994; 39: 713-20.
2. Matsumoto T, Iida M, Nakamura S, Hizawa K, Kuroki F, Fujishima M. Preventive effect of immunosuppressive agents against indomethacin-induced small intestinal ulcers in rats. Dig Dis Sci 1994; 39: 787-95.
3. Zeniya A, Otaka M, Kuwabara T, Fujimori S, Otani S, Masamune O. Anti-ulcer effect of FK506, immunosuppressive agent, in rats. J Gastroenterol 1994; 29: 383-4.
4. Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Screiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 1991; 66: 807-15.
5. McKeon F. When worlds collide: Immunosuppressants meet protein phosphatases. Cell 1991; 66: 823-6.
6. Walsh CT, Zydowsky LD, McKeon FD. Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction. J Biol Chem 1992; 267: 13115-18.
7. Chang HY, Takei K, Sydor AM, Born T, Rusnak F, Jay DG. Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin. Nature 1995; 376: 686-90.
8. ++-calmodulin-dependent phosphorylation and dephosphorylation of rat parotid secretion granules. Biochem Biophys Res Commun 1995; 215: 75-81.
9. 2+/calmodulin-dependent protein phosphatase and secretion in pancreatic acinar cells. J Biol Chem 1994; 269: 15111-17.
10. Hendey B, Klee CB, Maxfield FR. Inhibition of neutrophil chemokinesis on vitronectin by inhibitors of calcineurin. Science 1992; 258: 296-9.
11. 2+- and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils. Nature 1995; 377: 75-9.
12. Malhotra R, Raffaniello R, Raufman JP. Protein phosphatase-2B (calcineurin) plays a role in mediating calcium-induced pepsinogen secretion from gastric chief cells. Gastroenterology 1993; 104: A139.
13. Raufman JP, Lin JL, Raffaniello RD. Calcineurin mediates calcium-induced potentiation of adenyl cyclase activity in dispersed chief cells from guinea pig stomach. J Biol Chem 1996; 271: 19877-82.
14. Hunter T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 1995; 80: 225-36.
15. McLean IW, Nakane PK. Periodate-lysine-paraformaldehyde fixative: a new fixative for immunoelectron microscopy. J Histochem Cytochem 1974; 22: 1077-83.
16. Shay H, Komarov SA, Fels SS, Meranze D, Gruenstein M, Siplet HA. Simple method for the uniform production of gastric ulceration in the rat. Gastroenterology 1945; 5: 43-6.
17. Ghosh MN, Schild HO. Continuous recording of acid gastric secretion in the rat. Br J Pharmacol 1958; 13: 54-61.
18. Baukal AJ, Hunyady L, Catt KJ, Balla T. Evidence for participation of calcineurin in potentiation of agonist-stimulated cyclic AMP formation by the calcium-mobilizing hormone, angiotensine II. J Biol Chem 1994; 269: 24546-9.
19. Tan YH. Yin and yang of phosphorylation in cytokine signaling. Science 1993; 262: 376-7.
20. 2+. Am J Physiol 1989; 257: G99-110.
21. Chew CS. Parietal cell protein kinases. Selective activation of type I cAMP-dependent protein kinase by histamine. J Biol Chem 1985; 260: 7540-50.
22. Chew CS, Brown MR. Histamine increases phosphorylation of 27- and 40-kDa parietal cell proteins. Am J Physiol 1987; 253: G823-9.
23. Forte JG, Hanzel DK, Urushidani T, Wolosin JM. Pumps and pathway for HCl secretion. Ann NY Acad Sci 1989; 574: 145-58.
24. Urushidani T, Hanzel DK, Forte JG. Protein phosphorylation associated with stimulation of rabbit gastric glands. Biochim Biophys Acta 1987; 930: 209-19.
25. Urushidani T, Hanzel DK, Forte JG. Characterization of an 80-kDa phosphoprotein involved in parietal cell stimulation. Am J Physiol 1989; 256: G1070-81.
26. Chuang CN, Chen MC, Soll AH. The pathways regulating acid secretion: the view from the isolated cell. Yale. J Biol Med 1994; 67: 107-12.
27. Hohne-Zell B, Galler A, Schepp W, Gratzl M, Prinz C. Functional importance of synaptobrevin and SNAP-25 during exocytosis of histamine by rat gastric enterochromaffin-like cells. Endocrinology 1997; 138: 5518-26.
28. Soll AH. Antisecretory drugs: cellular mechanisms of action. Aliment Pharmacol Ther 1987; 1: 77-89.
29. Zhao CM, Chen D, Andersson K, Hakanson R. ECL cells of the rat stomach: development of lipofuscin in response to sustained gastrin stimulation. Cell Tissue Res 1998; 291: 315-23.
30. Shay H. Etiology of peptic ulcer. Am J Dig Dis 1961; 6: 29-43.
31. Kitagawa H, Fujiwara M, Osumi Y. Effects of water-immersion stress on gastric secretion and mucosal blood flow in rats. Gastroenterology 1979; 77: 298-302.
32. Nishikawa H, Takeda F, Kitagawa H, Kohei H. Roles of gastric acid secretion and motility in gastric mucosal lesion formation induced by water-immersion stress in rats. Scand J Gastroenterol 1989; 162: 11-1.