Mechanisms underlying UV-induced immune suppression: Implications for sunscreen design

Experimental Dermatology, Supplement

Volumn 11, Issue 1, 2002, Pages 13-16

  Ullrich, Stephen E ^a   Kripke, Margaret L ^a   Ananthaswamy, Honnavara N ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Delayed type hypersensitivity; DNA damage; Immune suppression; Skin cancer; Solar simulated UV radiation; Sunscreens; Suppressor T cells; UV radiation

Indexed keywords

DNA; INTERLEUKIN 10 ANTIBODY; MONOCLONAL ANTIBODY; PYRIMIDINE DIMER; RECOMBINANT INTERLEUKIN 12; SUNSCREEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELL MIGRATION; DNA DAMAGE; DRUG ACTIVITY; DRUG EFFICACY; ERYTHEMA; IMMUNE RESPONSE; IMMUNITY; LANGERHANS CELL; MOUSE; NONHUMAN; RADIATION EXPOSURE; RADIATION PROTECTION; SKIN; SPECTRAL SENSITIVITY; SPLEEN; SUNBURN; SUNLIGHT; SUPPRESSOR CELL; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; ULTRAVIOLET RADIATION; ANIMAL; CHEMISTRY; DRUG EFFECT; DRUG INDUSTRY; IMMUNOLOGICAL TOLERANCE;

ANIMALS; DRUG INDUSTRY; IMMUNE TOLERANCE; MICE; SUNSCREENING AGENTS; ULTRAVIOLET RAYS;

EID: 19044383380     PISSN: 14791250     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0625.11.s.1.4.x     Document Type: Article

References (12)

1. Nghiem D X, Kazimi N, Clydesdale G, Ananthaswamy H N, Kripke M L, Ullrich S E. Ultraviolet A radiation suppresses an established immune response: implications for sunscreen design. J Invest Dermatol 2001: 117: 1193-1199.
2. Nghiem D X, Kazimi N, Mitchell D L et al. Mechanisms underlying the suppression of established immune responses by UV radiation. J Invest Dermatol 2002: in press.
3. Moyal D, Courbière C, Le Corre Y, de Lacharrière O, Hourseau C. Immunosuppression induced by chronic solar-simulated irradiation in humans and its prevention by sunscreens. Eur J Dermatol 1997: 7: 223-225.
4. Damian D L, Halliday G M, Taylor C A, Barnetson R S C. Ultraviolet radiation induced suppression of Mantoux reactions in humans. J Invest Dermatol 1998: 110: 824-827.
5. Damian D L, Halliday G M, Barnetson R S C. Broadspectrum sunscreens provide greater protection against ultraviolet-radiation-induced suppression of contact hypersensitivity to a recall antigen in humans. J Invest Dermatol 1997: 109: 146-151.
6. Magee M J, Kripke M L, Ullrich S E. Suppression of the elicitation of the immune response to alloantigen by ultraviolet radiation. Transplantation 1989: 47: 1008-1013.
7. Denkins Y, Fidler I J, Kripke M L. Exposure of mice to UVB radiation suppresses delayed hypersensitivity to Candida albicans. Photochem Photobiol 1989: 49: 615-619.
8. Ullrich S E. Photoimmune suppression and photocarcinogenesis. Front Biosci 2002: 7: D684-703. http://www.bioscience.org/2002/v7/d/ullrich/list.htm
9. Moyal D D, Fourtanier A M. Broad-spectrum sunscreens provide better protection from the suppression of the elicitation phase of delayed-type hypersensitivity response in humans. J Invest Dermatol 2001: 117: 1186-1192.
10. Damian D L, Barnetson R S C, Halliday G M. Measurement of in vivo sunscreen immune protection factors in humans. Photochem Photobiol 1999: 70: 910-915.
11. Kripke M L, Cox P A, Alas L G, Yarosh D B. Pyrimidine dimers in DNA initiate systemic immunosuppression in UV-irradiated mice. Proc Natl Acad Sci U S A 1992: 89: 7516-7520.
12. Ley R D, Fourtanier A. Sunscreen protection against ultraviolet radiation-induced pyrimidine dimers in mouse epidermal DNA. Photochem Photobiol 1997: 65: 1007-1011.