Blockade of Rennin-Angiotensin system blunts the fibrotic response in experimental acute pyelonephritis

Journal of Indian Association of Pediatric Surgeons

Volumn 10, Issue 1, 2005, Pages 20-24

  Singal, A K ^a   Bajpai, M ^a   Dinda, A K ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Agiotensin converting enzyme inhibitor; Agiotensin receptor blocker; Experimental pyelonephritis; Lumbotomy incision; Renal scar; Renin angiotensin system

Indexed keywords

ANTIBIOTIC AGENT; CAPTOPRIL; CEFOTAXIME; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LOSARTAN;

ACUTE PYELONEPHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; FIBROSIS; HISTOPATHOLOGY; INOCULATION; KIDNEY; KRUSKAL WALLIS TEST; NONHUMAN; PARENCHYMA; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SCAR FORMATION; STATISTICAL SIGNIFICANCE; SURGICAL TECHNIQUE;

EID: 19044379751     PISSN: 09719261     EISSN: 09719261     Source Type: Journal    
DOI: 10.4103/0971-9261.16070     Document Type: Article

References (14)

1. Glauser MP, Meylan P, Bille J. The inflammatory response and tissue damage. Pediatr Nephrol 1987;1:615-9.
2. Roberts JA, Kaack MB, Baskin G. Treatment of experimental pyelonephritis in the monkey. J Urol 1990;143:150-4.
3. Haraoka M, Matsumoto T, Takahashi K, Kubo S, Tanaka M, Kumazawa J. Suppresssion of renal scarring by prednisolone combined with ciprofloxacin in ascending pyelonephritis in rats. J Urol 1994;151:1078-80.
4. Yagmurlu A, Boleken ME, Ertoy D, et al. Preventive effect of Pentoxiphylline on renal scarring in rat model of pyelonephritis. Urology 2003;61:1037-41.
5. Pohl HG, Rushton HG, Park JS, Chandra R, Majd M. Adjunctive oral corticosteroids reduce renal scarring: The piglet model of reflux and acute experimental pyelonephritis. J Urol 1999;162:815-20.
6. Haraoka M, Matsumoto T, Mizonoe Y. Effect of ebselen on renal scarring in rats following renal infection. Chemotherapy 1995;41:208-12.
7. Bennett RT, Mazzaccaro, Chopra RJ, Melman A, Fanco I. Suppression of renal inflammation with vitamin A and E in ascending pyelonephritis in rats. J Urol 1999;161:1681-4.
8. Kavakcu S, Soylu A, Tirkmen M, Sarioglu S, Buyukgebiz B, Gure A. The role of vitamin a in preventing renal scarring secondary to pyelonephritis. Br J Urol 1999;83:1055-9.
9. Huang A, Palmer LS, Hom D, Anderson AE, Kushner L, Franco I. Ibuprufen combined with antibiotics suppresses renal scarring due to ascending pyelonephritis in rats. J Urol 1999;162:1396-8.
10. Khalil A, Tullus K, Bakhiet M, Burman LG, Jaremko G, Brauner A. Angiotensin II type I receptor antagonist (Losartan) down regulates transforming growth factor-â in experimental acute pyelonephritis. J Urol 2000;164:186-91.
11. Taal MW, Brenner BM. Renoprotective benefits of RAS inhibition: From ACE I to angiotensin II antagonists. Kidney Int 2000;57:1803-17.
12. Serlachius E, Sundelin B, Eklof AN, Jahnke M, Laestadius A, Aperia A. Pyelonephritis provokes growth retardation and apoptosis in infant rat renal cortex. Kidney Int 1997;51:1855-62.
13. Slotki IN, Asscher AW. Prevention of renal scarring in experimental pyelonephritis in the rat by early antibiotic therapy. Nephron 1982;30:262-8.
14. Bajpai M, Kumar A, Gupta AK, Pawar DK. Lumbotomy approach for upper urological tract surgery in children-an analysis of 68 consecutive lumbotomies. Eur J Pediatr Surg 2004;14:163-7.