Urinary metabolites of workers exposed to nitrotoluenes

Biomarkers

Volumn 10, Issue 1, 2005, Pages 10-28

  Jones, C R ^a,b,c   Sepai, O ^c   Liu, Y Y ^d   Yan, H ^d   Sabbioni, Gabriele ^a,b  

^a Institute of Environmental and Occupational Toxicology   (Switzerland)

^b UNIVERSITY OF MUNICH   (Germany)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

Biomonitoring; Dinitrotoluene; Health effects; Metabolism; Nitrotoluene; Urine

Indexed keywords

2 NITROBENZOIC ACID; 2 NITROBENZYL ALCOHOL; 2 NITROTOLUENE; 2,4 DINITROBENZOIC ACID; 2,4 DINITROBENZYL ALCOHOL; 2,4 DINITROTOLUENE; 2,6 DINITROBENZOIC ACID; 2,6 DINITROBENZYL ALCOHOL; 2,6 DINITROTOLUENE; 4 AMINO 2 NITROBENZOIC ACID; 4 NITROANTHRANILIC ACID; 4 NITROBENZOIC ACID; 4 NITROBENZYL ALCOHOL; BENZYL ALCOHOL; CARCINOGEN; CREATININE; NITROBENZOIC ACID DERIVATIVE; TOLUENE DERIVATIVE; UNCLASSIFIED DRUG;

ABSORPTION; ADULT; AIR ANALYSIS; AIR MONITORING; ARTICLE; BIOLOGICAL MONITORING; CALIBRATION; CARCINOGENICITY; CHEMICAL INDUSTRY; CHEMICAL STRUCTURE; CHINA; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE URINE LEVEL; DETOXIFICATION; FEMALE; GAS CHROMATOGRAPHY; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; METABOLITE; OCCUPATIONAL EXPOSURE; OCCUPATIONAL TOXICOLOGY; PREDICTION; QUANTITATIVE ANALYSIS; URINALYSIS;

ANIMALIA;

EID: 19044369143     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.1080/13547500500079670     Document Type: Article

References (21)

1. Angerer J, Weismantel A. 1998. Biological monitoring of dinitrotoluene by gas chromatographic-mass spectrometric analysis of 2,4-dinitrobenzoic acid in human urine. Journal of Chromatography B 713:313-322.
2. Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL. 2005. Urinary creatinine concentrations in the US population: implications for urinary biological monitoring measurements. Environmental Health Perspectives 113:192-200.
3. Brüning T, Chronz C, Their R, Havelka J, Ko Y, Bolt HM. 1999. Occurrence of urinary tract tumors in miners highly exposed to dinitrotoluene. Journal of Occupational and Environmental Medicine 41:144-149.
4. Dunnick JK, Burka LT, Mahler J, Sills R. 2003. Carcinogenic potential of o-nitrotoluene and p-nitrotoluene. Toxicology 183:221-234.
5. Gal'bershtam MA, Budarina ZN. 1969. Synthesis of para-substituted o-nitrobenzyl alcohols. Zhurnal Organischeskoi Khimii 5:953-956.
6. International Agency for Cancer Research. 1996. Printing processes and printing inks, carbon black and some nitro compounds. Monographs on the evaluation of carcinogenic risks to humans, Vol. 65. Lyon: IARC.
7. Levine RJ, Tuner MJ, Crume YS, Dale ME, Starr TB, Rickert DE. 1985. Assessing exposure to dinitrotoluene using a biological monitor. Journal of Occupational Medicine 27:627-638.
8. McGee LM, McCausland A, Plume CA, Marlett NC. 1942. Metabolic disturbances in workers exposed to dinitrotoluene. American Journal of Digestion and Disposition 9:329-332.
9. Mori M, Inoue M, Nunozawa T, Miyahara T, Kozuka H. 1986. Preparation of some acetylated reduced and oxidised derivatives of 2,4-diaminotoluene and 2,6-dinitrotoluene. Chemical Pharmaceutical Bulletin 34:4859-4861.
10. NTUP. 2002a. Technical report on the toxicology and carcinogenesis studies of o-nitrotoluene (CAS NO. 88-72-2) in F344/N rats and B6C3F1 mice (feed studies). May 2002. NTP TR 504, NIH Publication No. 02-4438. National Toxicology Program.
11. NTP. 2002b. Technical report on the toxicology and carcinogenesis studies of p-nitrotoluene (CAS NO. 99-99-0) in F344/N rats and B6C3F1 mice (feed studies). May 2002, NTP TR 498, NIH Publication No. 01-4432. National Toxicology Program.
12. Rickert DE. 1985. Toxicity of nitroaromatic compounds. Washington: Hemisphere.
13. Rickert DE. 1987. Metabolism of nitroaromatic compounds. Drug Metabolism and Disposition 18:23-53.
14. Rickert DE, Long RM. 1981. Metabolism and excretion of 2,4-dinitrotoluene in male and female Fisher 344 rats after different doses. Drug Metabolism and Disposition 9:226-232.
15. Rickert DE, Long RM. 1982. Metabolism and excretion of 2,6-dinitro[14C]toluene in vivo and in isolated perfused rat livers. Drug Metabolism and Disposition 10:455-458.
16. Rickert DE, Butterworth BE, Popp JA. 1984. Dinitrotoluene: acute toxicity, oncogenicity, genotoxicity and metabolism. Critical Reviews of Toxicology 13:217-234.
17. Schmidt TC, Steinbach K, Buetehorn U, Heck K, Volkwein U, Gottfried S. 1999. Synthesis of reference substances for highly polar metabolites of nitroaromatic compounds. Chemosphere 38:3199-3130.
18. Smith EF, Smith HJ, Kuchar EJ. 1995. Monitoring of dinitrotoluene and its metabolites in urine by spectrophotometry of their coupled arlydiazonium salts. American Industrial Hygiene Association Journal 56:1175-1179.
19. Stayner LT, Dannenberg AL, Bloom T, Thun M. 1993. Excess hepatobiliary cancer mortality among munition s workers exposed to dinitrotoluene. Journal of Occupational Medicine 35:291-306.
20. Turner MJ Jr, Levine RJ, Nystrom DD, Crume YS, Rickert DE. 1985. Identification and quantification of urinary metabolites of dinitrotoluenes in occupationally exposed humans. Toxicology and Applied Pharmacology 80:166-174.
21. Woollen BH, Hall MG, Craug R, Stell GT. 1985. Dinitrotoluene: an assessment of occupational absorption during manufacture of blasting explosive. International Archives of Occupational and Environmental Health 55:319-330.