Sildenafil for the treatment of altitude-induced hypoxaemia

Expert Opinion on Pharmacotherapy

Volumn 6, Issue 5, 2005, Pages 835-837

  Perimenis, Petros ^a  

^a UNIVERSITY OF PATRAS   (Greece)

Author keywords

Altitude induced hypoxaemia; Cardiac output; Exercise; Pulmonary hypertension; Sildenafil

Indexed keywords

PLACEBO; SILDENAFIL;

AEROBIC CAPACITY; ALTITUDE DISEASE; ARTERIAL OXYGEN SATURATION; ARTICLE; CARDIOVASCULAR SYSTEM; CLINICAL TRIAL; COLOR VISION DEFECT; DRUG RESPONSE; DYSPEPSIA; FLUSHING; HEART OUTPUT; HEMODYNAMICS; HUMAN; HYPOXEMIA; LUNG ARTERY PRESSURE; LUNG CIRCULATION; LUNG GAS EXCHANGE; LUNG HEMODYNAMICS; MYALGIA; OXYGEN CONSUMPTION; PULMONARY HYPERTENSION; SIDE EFFECT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; SYSTOLE;

ALTITUDE; ALTITUDE SICKNESS; ANOXEMIA; HUMANS; PIPERAZINES;

EID: 19044368193     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.6.5.835     Document Type: Article

References (11)

1. RICHALET J-P, GRATADOUR P, ROBACH P et al.: Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension. Am. J. Respir. Crit. Care Med. (2005) 171:275-281.
2. HACKETT PH, ROACH RC: High-altitude illness. N. Engl. J. Med. (2001) 345:107-114.
3. RICH S, KAUFMANN E, LEVY PS: The effect of high doses of calcium channel blockers on survival in primary pulmonary hypertension. N. Engl. J. Med. (1992) 327:76-81.
4. BARST RJ, RUBIN LJ, LONG WA et al.: A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension. The Primary Pulmonary Hypertension Study Group. N. Engl. J. Med. (1996) 334:296-302.
5. RUBIN LJ, BADESCH DB, BARST RJ et al.: Bosentan therapy for pulmonary artery hypertension. N. Engl. J. Med. (2002) 346:896-903.
6. GALIE N, HUMBERT M, VACHIERY JL. for the Arterial Pulmonary Hypertension and Beraprost European (ALPHABET) Study Group: Effect of beraprost sodium, an oral prostacyclin analogue, in patients with pulmonary arterial hypertension. A randomized double blind placebo controlled trial. J. Am. Coll. Cardiol. (2002) 39:1496-1502.
7. OLSCHEWSKI H, SIMONNEAU G, GALIE N, for the Aerosolized Iloprost Randomized Study Group: Inhaled iloprost in severe pulmonary hypertension. N. Engl. J. Med. (2002) 347:322-329.
8. SASTRY BKS, NARASIMHAN C, KRISHNA REDDY N, SOMA RAJU B: Clinical efficacy of sildenafil in primary pulmonary hypertension. A randomized, placebo-controlled, double-blind, crossover study. J. Am. Coll. Cardiol. (2004) 43:1149-1153.
9. GHOFRANI HA, REICHENBERGER F, KOHSTALL MG et al.: Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann. Intern. Med. (2004) 141:169-177
10. DISHY V, SOFOWORA G, HARRIS PA et al.: The effect of sildenafil on nitric oxide-mediated vasodilation in healthy men. Clin. Pharmacol Ther. (2001) 70:270-279.
11. 5) gene expression is regulated during rat pulmonary development. Pediatr. Res. (1998) 43:163-168.