Carbohydrate-fat interactions and obesity examined by a two-compartment computer model

Obesity Research

Volumn 12, Issue 12, 2004, Pages 2013-2022

  Flatt, Jean Pierre ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Body weight regulation; Dietary fat; Exercise; Glycogen levels; System dynamics

Indexed keywords

GLYCOGEN;

ADIPOSE TISSUE; ARTICLE; BIOLOGICAL MODEL; BODY COMPOSITION; CALORIC INTAKE; CARBOHYDRATE DIET; CARBOHYDRATE METABOLISM; COMPUTER SIMULATION; ENERGY METABOLISM; FAT INTAKE; HUMAN; LIPID METABOLISM; METABOLISM; OBESITY; OXIDATION REDUCTION REACTION;

ADIPOSE TISSUE; BODY COMPOSITION; CARBOHYDRATE METABOLISM; COMPUTER SIMULATION; DIETARY CARBOHYDRATES; DIETARY FATS; ENERGY INTAKE; ENERGY METABOLISM; GLYCOGEN; HUMANS; LIPID METABOLISM; MODELS, BIOLOGICAL; OBESITY; OXIDATION-REDUCTION;

EID: 18944393189     PISSN: 10717323     EISSN: None     Source Type: Journal    
DOI: 10.1038/oby.2004.252     Document Type: Article

References (22)

1. Flatt JP. McCollum Award Lecture, 1995: diet, lifestyle and weight maintenance. Am J Clin Nutr. 1995;62:820-36.
2. Roberts SB, Young VR, Fuss P, et al. Energy expenditure and subsequent nutrient intakes in overfed young men. Am J Physiol. 1990;259:R461-9. (Pubitemid 20307566)
3. Bjorntorp P, Sjostrom L. Carbohydrate storage in man: speculations and some quantitative considerations. Metabolism. 1978;27:1853-65. (Pubitemid 9082243)
4. Flatt JP. The difference in the storage capacity for carbohydrate and for fat, and its implications in the regulation of body weight. Ann N Y Acad Sci. 1987;499:104-23.
5. Acheson KJ, Flatt JP, Jequier E. Glycogen synthesis versus lipogenesis after a 500 gram carbohydrate meal in man. Metabolism. 1982;31:1234-40. (Pubitemid 13223371)
6. Hellerstein MK. De novo lipogenesis in humans: metabolic and regulatory aspects. Eur J Clin Nutr. 1999;53:S53-65. (Pubitemid 29216871)
7. Jequier E, Acheson K, Schutz Y. Assessment of energy expenditure and fuel utilization in man. Ann Rev Nutr. 1987; 7:187-208.
8. Randle PJ, Hales CN, Garland PB, Newsholme EA. The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet. 1963;1: 785-9.
9. Rolls BJ, Rowe EA, Rolls ET, Kingston B, Megson A, Gunary R. Variety in a meal enhances food intake in man. Physiol Behav. 1981;26:215-21. (Pubitemid 11103522)
10. de Castro JM. Social facilitation of the spontaneous meal size of humans occurs on both weekdays and weekends. Physiol Behav. 1991;49:1289-91.
11. Flatt JP, Ravussin E, Acheson KJ, Jequier E. Effects of dietary fat on postprandial substrate oxidation and on carbohydrate and fat balances. J Clin Invest. 1985;76:1019-24. (Pubitemid 16225598)
12. Russek M. Current status of the hepatostatic theory of food intake control. Appetite. 1981;2:137-43.
13. Acheson KJ, Schutz Y, Bessard T, Anantharaman K, Flatt JP, Jequier E. Glycogen storage capacity and de novo lipogenesis during massive carbohydrate overfeeding in man. Am J Clin Nutr. 1988;48:240-7.
14. Obesity-Preventing and Managing the Global Epidemic. Report of a WHO Consultation Technical Report Series 2000. Geneva, Switzerland, 2000.
15. Mokdad AH, Bowman BA, Ford ES, Vinicor F, Marks JS, Kaplan PJ. The continuing epidemics of obesity and diabetes in the United States. J Am Med Assoc. 2001;286:1195-200. (Pubitemid 33015548)
16. Bray GA, Popkin BM. Dietary fat intake does affect obesity! Am J Clin Nutr. 1998;68:1157-73. (Pubitemid 28550944)
17. Willett WC. Dietary fat and obesity: an unconvincing relation. Am J Clin Nutr. 1998;68:1149-50. (Pubitemid 28550940)
18. Gortmaker SL, Must A, Sobel AM, Peterson K, Colditz GA, Dietz WH. Television viewing as a cause of increasing obesity among children in the United States, 1986-1990. Arch Pediatr Adolesc Med. 1996;150:356-62. (Pubitemid 26109216)
19. Dietary Reference Intakes: Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids. Report of the Institute of Medicine. Washington, DC: National Academies Press, 2000.
20. Flatt JP. How NOT to approach the obesity problem. Obes Res. 1997;5:632-3. (Pubitemid 127702687)
21. Bingham SA, Gill C, Welch A, et al. Comparison of dietary assessment methods in nutritional epidemiology: weighed records v. 24h recalls, food-frequency questionnaires and estimated-diet records. Br J Nutr. 1994;72:619-43. (Pubitemid 24317368)
22. Ludwig DH. Dietary glycemic index and obesity. J Nutr. 2000;130:280S-3S.