Beneficial effect of the addition of nitroglycerin to the cardioplegic solution on lipid peroxidation during coronary artery bypass surgery

International Heart Journal

Volumn 46, Issue 1, 2005, Pages 45-55

  Yavuz, Turhan ^a   Altuntas, Irfan ^a   Odabasi, Dolunay ^a   Delibas, Namik ^a   Ocal, Ahmet ^a   Ibrisim, Erdogan ^a   Kutsal, Ali ^b  

^a SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b TURKIYE YUKSEK IHTISAS HOSPITAL   (Turkey)

Author keywords

Coronary artery bypass; Lipid peroxidation; Nitric oxide; Nitroglycerin; Reperfusion injury

Indexed keywords

ANTIANGINA PECTORIS AGENT; CARDIOPLEGIC AGENT; GLYCERYL TRINITRATE; HEPARIN; MALONALDEHYDE; NITRIC OXIDE; NITRIC OXIDE DONOR; PLACEBO; PROTAMINE SULFATE; TROPONIN I;

ADULT; AGED; ANALYSIS OF VARIANCE; AORTA CLAMPING; ARTICLE; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; CORONARY ARTERY DISEASE; DOUBLE BLIND PROCEDURE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACORPOREAL CIRCULATION; FEMALE; HUMAN; INTERNAL MAMMARY ARTERY; LIPID PEROXIDATION; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; REPERFUSION INJURY; STERNOTOMY; BLOOD; CHEMISTRY; CORONARY ARTERY BYPASS GRAFT; MIDDLE AGED;

CARDIOPLEGIC SOLUTIONS; CARDIOPULMONARY BYPASS; CORONARY ARTERY BYPASS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; MIDDLE AGED; NITRIC OXIDE; NITROGLYCERIN; PROSPECTIVE STUDIES; TROPONIN I;

EID: 18944375951     PISSN: 13492365     EISSN: 13493299     Source Type: Journal    
DOI: 10.1536/ihj.46.45     Document Type: Article

References (32)

1. Ferrari R, Visioli O. Particular outcomes of myocardial ischemia: stunning and hibernation. Pharmacol Res 1995; 31: 235-41.
2. Menasche P, Piwnica A. Free radicals and myocardial protection: a surgical viewpoint. Ann Thorac Surg 1989; 47: 939-45.
3. Carlucci F, Tabucchi A, Biagioli B, et al. Cardiac surgery: myocardial energy balance, antioxidant status and endothelial function after ischemia-reperfusion. Biomed Pharmacother 2002; 56: 483-91.
4. Hochachka PW, Buck LT, Doll CJ, Land SC. Unifying theory of hypoxia tolerance: molecular/metabolic defence and rescue mechanisms for surviving oxygen lack. Proc Natl Acad Sci USA 1996; 93: 9493-8. (Review)
5. De Groot MC, Illing B, Horn M, et al. Endothelin-1 increases susceptibility of isolated rat hearts to ischemia/ reperfusion injury by reducing coronary flow. J Mol Cell Cardiol 1998; 30: 2657-68.
6. Hisotami K, Maruyama H, Isomura. T, Aoyagi S, Kasuga K, Ohishi F. Beneficial effect of the addition of nitro-glycerin to the cardioplegic solution on the cold-stored reperfused isolated rat heart. Jpn Circ J 1993; 57: 558-62.
7. Landymore R, Colvin S, Isom W, Cullifofd A. The effect of nitroglycerin cardioplegia on myocardial cooling in patients undergoing myocardial revascularization. Ann Thorac Surg 1983; 35: 621-5.
8. Dehoux M, Provenchere S, Benessiano J, et al. Utility of cardiac troponin measurement after cardiac surgery. Clin Chim Acta 2001; 311: 41-4.
9. England MD, Cavarocchi NC, O'Brien JF, et al. Influence of antioxidants (mannitol and allopurinol) on oxygen free radical generation during and after cardiopulmonary bypass. Circulation 1986; 74 (Suppl III): III. 134-7.
10. Kalweit GA, Schipke JD, Godehardt E, Gams E. Changes in coronary vessel resistance during postischemic reperfusion and effectiveness of nitroglycerin. J Thorac Cardiovasc Surg 2001; 122: 1011-8.
11. Davies SW, Underwood SM, Wickens DG, Feneck RO, Dormandy TL, Walesby RK. Systemic pattern of free radical generation during coronary bypass surgery. Br Heart J 1990; 64: 236-40.
12. Draper HH, Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 1990; 186: 421-31.
13. Cortas NK, Wakid NW. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 1990; 36: 1440-3.
14. Bolli R, Patel BS, Jeroudi MO, Lai EK, McCay PB. Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl-N-tert-butyl nitrone. J Clin Invest 1988; 82: 476-85.
15. Kharazmi A, Andersen LW, Baek L, Valerius NH, Laub M, Rasmussen JP. Endotoxemia and enhanced generation of oxygen radicals by neutrophils from patients undergoing cardiopulmonary bypass. J Thorac Cardio-vasc Surg 1989; 98: 381-5.
16. Inselmann G, Kohler K, Lange V, Silber R, Nellessen U. Lipid peroxidation and cardiac troponin T release during routine cardiac surgery. Cardiology 1998; 89: 124-9.
17. Davies SW, Ranjadayalan K, Wickens DG, Dormandy TL, Timmis AD. Lipid pefoxidation associated with successful thrombolysis. Lancet 1990; 335: 741-3.
18. Young IS, Purvis JA, Lightbody JH, Adgey AAJ, Trimble ER. Lipid peroxidation and antioxidant status following thrombolytic therapy for acute myocardial infarction. Eur Heart J 1993; 14: 1027-33.
19. Jessup W, Mohr D, Gieseg SP, Dean RT, Stocker R. The participation of nitric oxide in cell free- and its restriction of macrophage-mediated oxidation of low-density lipoprotein. Biochim Biophys Acta 1992; 1180: 73-82.
20. Padmaja S, Huie RE. The reaction of nitric oxide with organic peroxyl radicals. Biochem Biophys Res Commun 1993; 195: 539-44.
21. Ohlin H, Pavlidis N, Ohlin AK. Effect of intravenous nitroglycerin on lipid peroxidation after thrombolytic therapy for acute myocardial infarction. Am J Cardiol 1998; 82: 1463-7.
22. Vermes E, Mesguich M, Houel R, et al. Cardiac troponin I release after open heart surgery: a marker of myocardial protection? Ann Thorac Surg 2000; 70: 2087-90.
23. Lofberg M, Tahtela R, Harkonen M, Somer H. Cardiac troponins in severe rhabdomyolysis. Clin Chem 1996; 42: 1120-1.
24. Chocron S, Alwan K, Yan Y, et al. Warm reperfusion and myocardial protection. Ann Thorac Surg 1998; 66: 2003-7.
25. Yusuf S, Collins R, MacMahon S. Peto R. Effect of intravenous nitrates on mortality in acute myocardial infarction: an overview of the randomised trials. Lancet 1988; 1: 1088-92. (Review)
26. Paparella D, Yau TM, Young E. Cardiopulmonary bypass induced inflammation: pathophysiology and treatment. An update. Eur J Cardiothorac Surg 2002; 21: 232-44.
27. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990; 87: 1620-4.
28. Kelm M. Nitric oxide metabolism and breakdown. Biochim Biophys Acta 1999; 1411: 273-89. (Review)
29. Tsao PS, Lefer AM. Time course and mechanism of endothelial dysfunction in isolated ischemic- and hypoxic-perfused rat hearts. Am J Physiol 1990; 259: H1660-6.
30. Gorog DA, Ahmed N, Davies GJ. Elevated plasma hpid peroxide levels in angina pectoris and myocardial infarction. Cardiovasc Pathol 2002; 11: 153-7.
31. Sellke FW, Shafique T, Schoen FJ, Weintraub RM. Impaired endothelium-dependent coronary microvascular relaxation after cold potassium cardioplegia and reperfusion. J Thorac Cardiovasc Surg 1993; 105: 52-8.
32. Lefer AM, Tsao PS, Lefer DJ, Ma XL. Role of endothelial dysfunction in the pathogenesis of reperfusion injury after myocardial ischemia. FASEB J 1991; 5: 2029-34. (Review)