Differential immunogenicity of two peptides isolated by high molecular weight-melanoma-associated antigen-specific monoclonal antibodies with different affinities

Journal of Immunology

Volumn 174, Issue 11, 2005, Pages 7104-7110

  Luo, Wei ^a   Hsu, Jeff Chi Feng ^a   Tsao, Chun Yen ^a   Ko, Eric ^a   Wang, Xinhui ^a   Ferrone, Soldano ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; KEYHOLE LIMPET HEMOCYANIN; MELANOMA ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 763.74; MONOCLONAL ANTIBODY GH786; MONOCLONAL ANTIBODY MK2.23; PEPTIDE; PEPTIDE 763 74; PEPTIDE GH786; PEPTIDE LIBRARY; PEPTIDE MB1; PROTEASOME; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY AFFINITY; ANTIBODY TITER; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; CROSS LINKING; DELAYED HYPERSENSITIVITY; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; MELANOMA; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; TUMOR CELL LINE;

EID: 18944374761     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.11.7104     Document Type: Article

References (40)

1. Reisfeld, R. A., and D. A. Cheresh. 1987. Human tumor antigens. Adv. Immunol. 40: 323-377.
2. Rosenberg, S. A. 2001. Progress in human tumour immunology and immunotherapy. Nature 411: 380-384.
3. Boon, T., P. G. Coulie, and B. Van den Eynde. 1997. Tumor antigens recognized by T cells. Immunol. Today 18: 267-268.
4. Perales, M. A., N. E. Blachere, M. E. Engelhorn, C. R. Ferrone, J. S. Gold, P. D. Gregor, G. Noffz, J. D. Wolchok, and A. N. Houghton. 2002. Strategies to overcome immune ignorance and tolerance. Semin. Cancer Biol. 12: 63-71.
5. Perez-Diez, A., P. J. Spiess, N. P. Restifo, P. Matzinger, and F. M. Marincola. 2002. Intensity of the vaccine-elicited immune response determines tumor clearance. J. Immunol. 168: 338-347.
6. Nanni, P., L. Landuzzi, G. Nicoletti, C. De Giovanni, I. Rossi, S. Croci, A. Astolfi, M. Iezzi, E. Di Carlo, P. Musiani, et al. 2004. Immunoprevention of mammary carcinoma in HER-2/neu transgenic mice is IFN-γ and B cell dependent. J. Immunol. 173: 2288-2296.
7. Wang, X., W. Luo, K. A. Foon, and S. Ferrone. 2001. Tumor associated antigen (TAA) mimicry and immunotherapy of malignant diseases from anti-idiotypic antibodies to peptide mimics. Cancer Chemother. Biol. Response Modif. 19: 309-326.
8. Lo Gerfo, P., F. P. Herter, and S. J. Bennett. 1972. Absence of circulating antibodies to carcinoembryonic antigen in patients with gastrointestinal malignancies. Int. J. Cancer 9: 344-348.
9. Hamby, C. V., S. K. Liao, T. Kanamaru, and S. Ferrone. 1987. Immunogenicity of human melanoma-associated antigens defined by murine monoclonal antibodies in allogeneic and xenogeneic hosts. Cancer Res. 47: 5284-5289.
10. Mittelman, A., Z. J. Chen, H. Yang, G. Y. Wong, and S. Ferrone. 1992. Human high molecular weight melanoma-associated antigen (HMW-MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage IV melanoma. Proc. Natl. Acad. Sci. USA 89: 466-470.
11. Livingston, P. O. 1993. Approaches to augmenting the IgG antibody response to melanoma ganglioside vaccines. Ann. NY Acad. Sci. 690: 204-213.
12. Chapman, P. B., P. O. Livingston, M. E. Morrison, L. Williams, and A. N. Houghton. 1994. Immunization of melanoma patients with anti-idiotypic monoclonal antibody BEC2 which mimics GD3 ganglioside: pilot trials using no immunological adjuvant. Vaccine Res. 3: 59-69.
13. Foon, K. A., M. Chakraborty, W. J. John, A. Sherratt, H. Kohler, and M. Bhattacharya-Chatterjee. 1995. Immune response to the carcinoembryonic antigen in patients treated with an anti-idiotype antibody vaccine. J. Clin. Invest. 96: 334-342.
14. Kieber-Emmons, T., P. Luo, J. Qiu, T. Y. Chang, I. O., M. Blaszczyk-Thurin, and Z. Steplewski. 1999. Vaccination with carbohydrate peptide mimotopes promotes anti-tumor responses. Nat. Biotechnol. 17: 660-665.
15. Kieber-Emmons, T., B. Monzavi-Karbassi, B. Wang, P. Luo, and D. B. Weiner. 2000. Cutting edge: DNA immunization with minigenes of carbohydrate mimotopes induce functional anti-carbohydrate antibody response. J. Immunol. 165: 623-627.
16. Riemer, A. B., M. Klinger, S. Wagner, A. Bernhaus, L. Mazzucchelli, H. Pehamberger, O. Scheiner, C. C. Zielinski, and E. Jensen-Jarolim. 2004. Generation of peptide mimics of the epitope recognized by trastuzumab on the oncogenic protein Her-2/neu. J. Immunol. 173: 394-401.
17. Yang, H., Z. J. Chen, T. Kageshita, M. Yamada, and S. Ferrone. 1993. Idiotypic cascade in the human high molecular weight melanoma-associated antigen system: fine specificity and idiotypic profile of anti-anti-idiotypic monoclonal antibodies. Eur. J. Immunol. 23: 1671-1677.
18. Chen, Z. J., H. Yang, and S. Ferrone. 1991. Human high molecular weight melanoma-associated antigen mimicry by mouse antiidiotypic monoclonal antibody MK2-23: characterization of the immunogenicity in syngeneic hosts. J. Immunol. 147: 1082-1090.
19. Chen, Z. J., H. Yang, C. C. Liu, S. Hirai, and S. Ferrone. 1993. Modulation by adjuvants and carriers of the immunogenicity in xenogeneic hosts of mouse antiidiotypic monoclonal antibody MK2-23, an internal image of human high molecular weight-melanoma associated antigen. Cancer Res. 53: 112-119.
20. Smith, G. P., and J. K. Scott. 1993. Libraries of peptides and proteins displayed on filamentous phage. Methods Enzymol. 217: 228-257.
21. Valadon, P., and M. D. Scharff. 1996. Enhancement of ELISAs for screening peptides in epitope phage display libraries. J. Immunol. Methods 197: 171-179.
22. Giacomini, P., A. K. Ng, R. R. Kantor, P. G. Natali, and S. Ferrone. 1983. Double determinant immunoassay to measure a human high-molecular-weight melanoma-associated antigen. Cancer Res. 43: 3586-3590.
23. 2- microglobulin-free HLA class I heavy chains. J. Immunol. 165: 3275-3283.
24. Grant, G. A. 2002. Coupling synthetic peptides to a carrier protein using a heterobifunctional reagent. In Current Protocols in Immunology, J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. Wiley & Sons, New York, p. 9.2.8.
25. Bonnycastle, L. L., J. S. Mehroke, M. Rashed, X. Gong, and J. K. Scott. 1996. Probing the basis of antibody reactivity with a panel of constrained peptide libraries displayed by filamentous phage. J. Mol. Biol. 258: 747-762.
26. Sanger, F., S. Nicklen, and A. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74: 5463-5467.
27. Matsui, M., M. Temponi, and S. Ferrone. 1987. Characterization of a monoclonal antibody-defined human melanoma-associated antigen susceptible to induction by immune interferon. J. Immunol. 139: 2088-2095.
28. Holmes, K., B. J. Fowlkes, I. Schmid, and J. V. Giorgi. 2002. Immunofluorescence staining of single-cell suspensions for detection of surface antigens. In Current Protocols in Immunology, J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, eds. Wiley & Sons, New York, p. 5.3.1.
29. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
30. Zweig, S. E., and E. M. Shevach. 1983. Production and properties of monoclonal antibodies to guinea pig Ia antigens. Methods Enzymol. 92: 66-85.
31. Srinivasan, R., A. N. Houghton, and J. D. Wolchok. 2002. Induction of autoantibodies against tyrosinase-related proteins following DNA vaccination: unexpected reactivity to a protein paralogue. Cancer Immun. 2: 8.
32. Cunto-Amesty, G., P. Luo, B. Monzavi-Karbassi, A. Lees, J. Alexander, M. F. del Guercio, M. H. Nahm, C. Artaud, J. Stanley, and T. Kieber-Emmons. 2003. Peptide mimotopes as prototypic templates of broad-spectrum surrogates of carbohydrate antigens. Cell. Mol. Biol. 49: 245-254.
33. Chapman, P. B., D. Wu, G. Ragupathi, S. Lu, L. Williams, W. J. Hwu, D. Johnson, and P. O. Livingston. 2004. Sequential immunization of melanoma patients with GD3 ganglioside vaccine and anti-idiotypic monoclonal antibody that mimics GD3 ganglioside. Clin. Cancer Res. 10: 4717-4723.
34. Naftzger, C., Y. Takechi, H. Kohda, I. Hara, S. Vijayasaradhi, and A. N. Houghton. 1996. Immune response to a differentiation antigen induced by altered antigen: a study of tumor rejection and autoimmunity. Proc. Natl. Acad. Sci. USA 93: 14809-14814.
35. Weber, L. W., W. B. Bowne, J. D. Wolchok, R. Srinivasan, J. Qin, Y. Moroi, R. Clynes, P. Song, J. J. Lewis, and A. N. Houghton. 1998. Tumor immunity and autoimmunity induced by immunization with homologous DNA. J. Clin. Invest. 102: 1258-1264.
36. Wagner, U., S. Kohler, S. Reinartz, P. Giffels, J. Huober, K. Renke, H. Schlebusch, H. J. Biersack, V. Mobus, R. Kreienberg, et al. 2001. Immunological consolidation of ovarian carcinoma recurrences with monoclonal antiidiotype antibody ACA125: immune responses and survival in palliative treatment. Clin. Cancer Res. 7: 1154-1162.
37. McCaffery, M., T.-J. Yao, L. Williams, P. O. Livingston, A. N. Houghton, and P. B. Chapman. 1996. Immunization of melanoma patients with BEC2 antiidiotypic monoclonal antibody that mimics GD3 ganglioside: enhanced immunogenicity when combined with adjuvant. Clin. Cancer Res. 2: 679-686.
38. + (MUC-16) ovarian cancer. Cancer Res. 63: 3234-3240.
39. Luo, P., G. Canziani, G. Cunto-Amesty, and T. Kieber-Emmons. 2000. A molecular basis for functional peptide mimicry of a carbohydrate antigen. J. Biol. Chem. 275: 16146-16154.
40. Forster-Waldl, E., A. B. Riemer, A. K. Dehof, D. Neumann, K. Bramswig, G. Boltz-Nitulescu, H. Pehamberger, C. C. Zielinski, O. Scheiner, A. Pollak, et al. 2005. Isolation and structural analysis of peptide mimotopes for the disialo-ganglioside GD2, a neuroblastoma tumor antigen. Mol. Immunol. 42: 319-325.