Transient gene expression of recombinant terpenoid indole alkaloid enzymes in Catharanthus roseus leaves

Plant Molecular Biology Reporter

Volumn 22, Issue 1, 2004, Pages 15-22

  Di Fiore, Stefano ^a   Hoppmann, Verena ^a,c   Fischer, Rainer ^a,b   Schillberg, Stefan ^b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b FRAUNHOFER INSTITUTE FOR MOLECULAR BIOLOGY AND APPLIED ECOLOGY IME   (Germany)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

Agroinfiltration; Catharanthus roseus; Strictosidine synthase; Transient gene expression; Tryptophan decarboxylase

Indexed keywords

AGROBACTERIUM TUMEFACIENS; CATHARANTHUS ROSEUS; RADIOBACTER; RHIZOBIUM;

EID: 18944374566     PISSN: 07359640     EISSN: 07359640     Source Type: Journal    
DOI: 10.1007/BF02773344     Document Type: Review

References (24)

1. Constabel F, Gaudet-LaPrairie P, Kurz WGW, and Kutney JP (1982) Alkaloid production in Catharanthus roseus cell cultures. XII. Biosynthetic capacity of callus from original explants and regenerated shoots. Plant Cell Rep 1: 139-42.
2. de Waal A, Meijer A, and Verpoorte R (1995) Strictosidine synthase from Catharanthus roseus: purification and characterization of multiple forms. Biochem J 306: 571-80.
3. Deus-Neumann B and Zenk M (1984) Instability of indole alkaloid production in Catharanthus roseus cell suspension cultures. Planta Med 50: 427-31.
4. Di Fiore S, Li Q, Leech M, Schuster F, Emans N, Fischer R, and Schillberg S (2002) Targeting tryptophan decarboxylase to selected subcellular compartments of tobacco plants affects enzyme stability and in vivo function and leads to a lesion-mimic phenotype. Plant Physiol 129: 1160-9.
5. Fernandez J, Owen TG, Kurz WGW, and De Luca V (1989) Immunological detection and quantitation of tryptophan decarboxylase in developing Catharanthus roseus seedlings. Plant Physiol 91: 79-84.
6. Fischer R, Vaquero-Martin C, Sack M, Drossard J, Emans N, and Commandeur U (1999) Towards molecular farming in the future: transient protein expression in plants. Biotechnol Appl Biochem 30: 113-6.
7. Hoppmann V, Di Fiore S, Zimmermann S, Emans N, Rademacher T, Fischer R, and Schillberg S (2002) The potato granule bound starch synthase chloroplast transit peptide directs recombinant proteins to plastids. J Plant Physiol 159: 1061-7.
8. Kapila J, De Rycke R, Van Montagu M, and Angenon G (1997) An Agrobacterium-mediated transient gene expression system for intact leaves. Plant Sci 122: 101-8.
9. Kim SW, Song NH, Jung KH, Kwak SS, and Liu JR (1994) High frequency plant regeneration from anther-derived cell suspension cultures via somatic embryogenesis in Catharanthus roseus. Plant Cell Rep 13: 319-22.
10. Koncz C and Schell J (1986) The promoter of T-L DNA gene 5 controls the tissue-specific expression of chimeric genes carried by a novel type of Agrobacterium binary vector. Mol Gen Genet 204: 383-96.
11. Leech M, May K, Hallard D, Verpoorte R, De Luca V, and Christou P (1998) Expression of two consecutive genes of a secondary metabolic pathway in transgenic tobacco: molecular diversity influences levels of expression and product accumulation. Plant Mol Biol 38: 765-74.
12. McKnight T, Bergey DR, Burnett RJ, and Nessler CL (1991) Expression of enzymatically active and correctly targeted strictosidine synthase in transgenic tobacco plants. Planta 185: 148-52.
13. Meijer AH, Verpoorte R, and Hoge JHC (1993) Regulation of enzymes and genes involved in terpenoid indole alkaloid biosynthesis in Catharanthus roseus. J Plant Res (Special Issue) 3: 145-64.
14. Moreno PRH, van der Heijden R, and Verpoorte R (1995) Cell and tissue cultures of Catharanthus roseus: a literature survey. II. Updating from 1988 to 1993. Plant Cell Tissue Organ Cult 42: 1-25.
15. Pennings EJM, Verpoorte R, Goddijn OJM, and Hoge JHC (1989) Purification of tryptophan decarboxylase from a Catharanthus roseus cell suspension culture. J Chrom A 483: 311-8.
16. Pfitzner U and Zenk MH (1989) Homogeneous strictosidine synthase isoenzymes from cell suspension cultures of Catharanthus roseus. Planta Med 55: 525-30.
17. Roessner CA, Devagupta R, Hasan M, Williams HJ, and Scott AI (1992) Purification of an indole alkaloid biosynthetic enzyme, strictosidine synthase, from a recombinant strain of Escherichia coli. Protein Expr Purif 3: 295-300.
18. St-Pierre B, Vazquez-Flota FA, and De Luca V (1999) Multicellular compartmentation of Catharanthus roseus alkaloid biosynthesis predicts intercellular translocation of a pathway intermediate. Plant Cell 11: 887-900.
19. van der Fits L, Hilliou F, and Memelink J (2001) T-DNA activation tagging as a tool to isolate regulators of a metabolic pathway from a genetically non-tractable plant species. Trans Res 10: 513-21.
20. Vaquero C, Sack M, Chandler J, Drossard J, Schuster F, Monecke M, Schillberg S, and Fischer R (1999) Transient expression of a tumor-specific single-chain fragment and a chimeric antibody in tobacco leaves. Proc Natl Acad Sci USA 96: 11128-33.
21. Vaquero C, Sack M, Schuster F, Finnern R, Drossard J, Schumann D, Reimann A, and Fischer R (2002) A carcinoembryonic antigen-specific diabody produced in tobacco. FASEB J 16: 408-10.
22. Vazquez-Flota F, De Luca V, Carrillo-Pech M, Canto-Flick A, and de Lourdes Miranda-Ham M (2002) Vindoline biosynthesis is transcriptionally blocked in Catharanthus roseus cell suspension cultures. Mol Biotechnol 22: 1-8.
23. Voss A, Niersbach M, Hain R, Hirsch H, Liao Y, Kreuzaler F, and Fischer R (1995) Reduced virus infectivity in N. tabacum secreting a TMV-specific full-size antibody. Mol Breed 1: 39-50.
24. Whitmer S, Canel C, van der Heijden R, and Verpoorte R (2003) Long-term instability of alkaloid production by stably transformed cell lines of Catharanthus roseus. Plant Cell Tissue Organ Cult 74: 73-80.