The patellazoles inhibit protein synthesis at nanomolar concentrations in human colon tumor cells

Anti-Cancer Drugs

Volumn 16, Issue 5, 2005, Pages 533-541

  Richardson, Adam D ^a   Aalbersberg, William ^b   Ireland, Chris M ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF THE SOUTH PACIFIC   (Fiji)

Author keywords

Cell cycle arrest; Colon tumor; Cytotoxicity; mTOR; Patellazole; Rapamycin; Translation

Indexed keywords

DIMETHYL SULFOXIDE; EPOXIDE; INITIATION FACTOR 4E BINDING PROTEIN 1; MACROLIDE; MAMMALIAN TARGET OF RAPAMYCIN; PATELLAZOLE; PATELLAZOLE A; PATELLAZOLE B; PATELLAZOLE C; PATELLAZOLE H; PATELLAZOLE I; PATELLAZOLE J; PROTEIN P53; PROTEIN P70; RIBOSOME PROTEIN; S6 KINASE; THIAZOLE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL STRAIN HCT116; COLON TUMOR; CONTROLLED STUDY; CYTOTOXICITY; DNA MICROARRAY; DRUG STRUCTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RNA ISOLATION; STRUCTURE ACTIVITY RELATION; WESTERN BLOTTING; WILD TYPE;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; MACROLIDES; NANOTECHNOLOGY; NEOPLASM PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; UROCHORDATA;

EID: 18844456102     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200506000-00009     Document Type: Article

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