A generic approach to the impurity profiling of drugs using standardised and independent capillary zone electrophoresis methods coupled to electrospray ionisation mass spectrometry

Electrophoresis

Volumn 26, Issue 9, 2005, Pages 1712-1723

  Vassort, Aurélie ^a   Barrett, David A ^a   Shaw, P Nicholas ^a   Ferguson, Paul D ^b   Szucs, Roman ^b  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Capillary zone electrophoresis; Impurity profiling; Liquid chromatography; Mass spectrometry; Orthogonality

Indexed keywords

CAPILLARY ELECTROPHORESIS; DRUG PRODUCTS; ELECTRODEPOSITION; ELECTROLYTES; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHANOL; ORGANIC SOLVENTS;

AMMONIUM ACETATE; CAPILLARY-ZONE ELECTROPHORESIS; DRUG CANDIDATES; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; GENERIC APPROACH; IMPURITY PROFILING; METHANOL-WATER; ORGANICS; ORTHOGONALITY; PROCESS-RELATED IMPURITIES;

MASS SPECTROMETRY;

ACETONITRILE; AMMONIUM ACETATE; AMMONIUM FORMATE; FUNCTIONAL GROUP; METHANOL; ORGANIC SOLVENT; PIPERIDINE;

ANALYTIC METHOD; ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; DRUG IMPURITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FACTORIAL ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; LIPOPHILICITY; METHODOLOGY; STRUCTURE ANALYSIS;

EID: 18844435402     PISSN: 01730835     EISSN: None     Source Type: Journal    
DOI: 10.1002/elps.200410261     Document Type: Article

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