Ampicillin/penicillin-binding protein interactions as a model drug-target system to optimize affinity pull-down and mass spectrometric strategies for target and pathway identification

Proteomics

Volumn 5, Issue 7, 2005, Pages 1764-1773

  Von Rechenberg, Moritz ^a   Blake, Brian Kelly ^a   Ho, Yew Seng J ^a   Zhen, Yuejun ^a,b   Chepanoske, Cindy Lou ^a   Richardson, Bonnie E ^a   Xu, Nafei ^a   Kery, Vladimir ^a,c  

^a Prolexys Pharmaceuticals Inc   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

Drug affinity purification; Matrix assisted laser desorption ionization; Penicillin binding protein; Two dimensional liquid chromatography tandem mass spectrometry

Indexed keywords

AMPICILLIN; AMPICILLIN BINDING PROTEIN; DRUG BINDING PROTEIN; N LAUROYLSARCOSINE; PENICILLIN BINDING PROTEIN; PENICILLIN DERIVATIVE; RESIN; SARCOSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL BOND; DRUG TARGETING; ELUTION; ESCHERICHIA COLI; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN IMMOBILIZATION; PROTEIN INTERACTION; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY;

AMPICILLIN; DRUG DELIVERY SYSTEMS; MASS SPECTROMETRY; MICROSPHERES; PENICILLIN-BINDING PROTEINS; SARCOSINE; SEPHAROSE;

ESCHERICHIA COLI;

EID: 18844420249     PISSN: 16159853     EISSN: None     Source Type: Journal    
DOI: 10.1002/pmic.200301088     Document Type: Article

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