Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: Treatment with double filtration plasmapheresis and prednisolone

American Journal of the Medical Sciences

Volumn 329, Issue 5, 2005, Pages 259-264

  Koyama, Rikako ^a   Nakanishi, Koji ^a,b   Kato, Masako ^a   Yamashita, Shigeo ^a   Kuwahara, Hiroya ^a,b   Katori, Hideyuki ^a,b  

^a TORANOMON HOSPITAL   (Japan)

^b Okinaka Memorial Institute for Medical Research   (Japan)

Author keywords

Double filtration plasmapheresis; Hypoglycemia; Insulin antibodies; Prednisolone; Scatchard analysis

Indexed keywords

GLUCOSE; HUMAN INSULIN; INSULIN ANTIBODY; INSULIN LISPRO; ISOPHANE INSULIN; PREDNISOLONE;

AGED; ARTICLE; BINDING AFFINITY; CASE REPORT; DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN BINDING; INSULIN TREATMENT; MALE; PLASMAPHERESIS; POSTPRANDIAL STATE; SCATCHARD PLOT; TREATMENT INDICATION; TREATMENT OUTCOME;

EID: 18844414023     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000441-200505000-00007     Document Type: Article

References (25)

1. Van Haeften TW. Clinical significance of insulin antibodies in insulin-treated diabetic patients. Diabetes Care 1989;12: 641-8.
2. Asplin C, Raghu P, Clemons P, et al. Randomized prospective trial of pure porcine and conventional bovine/porcine insulin. Diabetes Care 1987;10:337-42.
3. Wredling R, Lins PE, Adamson U. Prevalence of antiinsulin antibodies and its relation to severe hypoglycaemia in insulin-treated diabetic patients. Scand J Clin Lab Invest 1990;50:551-7.
4. Hirata Y, Ishizu H, Ouchi N, et al. Insulin autoimmunity in a case with spontaneous hypoglycemia. J Japan Diab Soc 1970;13:312-20.
5. Hirata Y, Arimichi M. Insulin autoimmune syndrome: the second case. J Japan Diab Soc 1972;15:187-92.
6. Hirata Y, Tominaga M, Ito J, et al. Spontaneous hypoglycemia with insulin autoimmunity in Graves' disease. Ann Intern Med 1974;81:214-8.
7. Nakanishi K, Kobayashi T, Sugimoto T, et al. Predictive value of insulin autoantibodies for further progression of beta cell dysfunction in non-insulin-dependent diabetics. Diabetes Res 1988;9:105-9.
8. Rosenthal HE. A graphic method for the determination and presentation of binding parameters in a complex system. Anal Biochem 1967;20:525-32.
9. Kuzuya H, Blix PM, Horwitz DL, et al. Determination of free and total insulin and C-peptide in insulin-treated diabetics. Diabetes 1977;26:22-9.
10. Kembo T, Hirata Y. Immunoglobulin classes and light chain types of antiinsulin antibodies in insulin autoimmune syndrome. J Japan Diab Soc 1976;19:53-62.
11. Uchigata Y, Eguchi Y, Takayama-Hasumi S, et al. Insulin autoimmune syndrome (Hirata disease): clinical features and epidemiology in Japan. Diabetes Res Clin Pract 1994;22: 89-94.
12. Blackshear PJ, Rotner HE, Kriauciunas KAM, et al. Reactive hypoglycemia and insulin autoantibodies in drug-induced lupus erythematosus. Ann Intern Med 1983;99:182-4.
13. Uchigata Y, Kuwata S, Tokunaga K, et al. Strong association of insulin autoimmune syndrome with HLA-DR4. Lancet 1992;339:393-4.
14. Rojas M, Hulbert C, Thomas JW. Anergy and not clonal ignorance determines the fate of B cells that recognize a physiological autoantigen. J Immunol 2001;166:3194-200.
15. Harwood R. Insulin-binding antibodies and "spontaneous" hypoglycemia. N Engl J Med 1960;262:978-9.
16. Albert SG, Popp DA. Hypoglycemia due to serum-complexed insulin in a patient with diabetes mellitus. Diabetes Care 1984;7:285-90.
17. Van Haeften TW, Krom BA, Gerich JE. Prolonged fasting hypoglycemia due to insulin antibodies in patients with non-insulin-dependent diabetes mellitus: effect of insulin withdrawal on insulin-antibody-binding kinetics. Diabetes Care 1987;10:160-3.
18. Yasuda T, Ishikawa O, Ohigashi H, et al. Hypoglycemia induced by insulin antibody during postoperative management with intravenous hyperalimentation: a case report and qualitative analysis of insulin antibody. J Jpn Surg Soc 1989;90:949-52.
19. Suzuki K, Hirayama S, Ito S. A case of a non-insulin dependent diabetic patient with regular spontaneous hypoglycemic attacks, which were due to insulin-binding antibodies induced by human insulin therapy. Tohoku J Exp Med 1997;182:163-73.
20. Hayakawa T, Ohsawa K, Nagai Y, et al. Fasting hypoglycemia and postprandial hyperglycemia due to insulin antibodies in a patient with non-insulin-dependent diabetes mellitus. Evaluation by Scatchard analysis and euglycemic clamp study. J Japan Diab Soc 1993;36:531-7.
21. Takahashi S, Oida K, Miyamori I. A 75-year-old type 2 diabetes mellitus case responding strikingly to troglitazone: possible mechanism of insulin resistance induced by insulin antibody. Jpn J Geriat 2000;37:344-8.
22. Sakamoto N, Sakamoto Y, Maruyama M, et al. A type 1 diabetic patient with prolonged fasting hypoglycemia and postprandial hyperglycemia due to insulin autoimmune syndrome like insulin antibodies. Evaluation by Scatchard analysis. J Japan Diab Soc 2002;45:471-6.
23. + T cells that may abrogate immunologic insulin resistance in type 1 diabetes. J Clin Invest 1989;84:1479-87.
24. Agishi T. Selective removal of pathogenetic macromolecules directly from whole blood by double filtration technique. Int J Artif Organs 1986;9:355-8.
25. Kajimoto Y, Kawamori K, Fujitani Y, et al. A case of non-insulin dependent diabetes mellitus with antiinsulin antibody: effect of subcutaneous injection of human recombinant insulin-like growth factor-I. Endocr J 1995;42:101-5.