Human intervertebral disc aggrecan inhibits endothelial cell adhesion and cell migration in vitro

Spine

Volumn 30, Issue 10, 2005, Pages 1139-1147

  Johnson, William E B ^a   Caterson, Bruce ^b   Eisenstein, Stephen M ^a   Roberts, Sally ^a  

^a ROBERT JONES AND AGNES HUNT ORTHOPAEDIC HOSPITAL   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Aggrecan; Disc degeneration; Herniation; Intervertebral disc; Neovascularization

Indexed keywords

1,9 DIMETHYLMETHYLENE BLUE; AGGRECAN; CHONDROITIN ABC LYASE; CHONDROITIN SULFATE; COLLAGEN; GLYCOSAMINOGLYCAN POLYSULFATE; KERATAN SULFATE; KERATINASE; KERATINASE II; METHYLENE BLUE; MONOMER; PROTEOGLYCAN; UNCLASSIFIED DRUG;

ANNULUS FIBROSUS; CELL ADHESION; CELL CULTURE; CELL GROWTH; CELL LINE; CELL MIGRATION; CELL SPREADING; COLORIMETRY; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; INTERVERTEBRAL DISK HERNIA; NEOVASCULARIZATION (PATHOLOGY); NERVE GROWTH; NUCLEUS PULPOSUS; PRIORITY JOURNAL; SENSORY NERVE; VASCULARIZATION;

AGGRECANS; CELL ADHESION; CELL LINE; CELL MOVEMENT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; EXTRACELLULAR MATRIX PROTEINS; GLYCOSAMINOGLYCANS; HUMANS; INTERVERTEBRAL DISK; LECTINS, C-TYPE; LUMBAR VERTEBRAE; PROTEOGLYCANS;

EID: 18844413322     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.brs.0000162624.95262.73     Document Type: Conference Paper

References (48)

1. Crock HV, Yoshizawa H, Kame SK. Observations on the venous drainage of the human vertebral body. J Bone Joint Surg Br 1973;55:528-33.
2. Crock HV, Yoshizawa H. The blood supply of the lumbar vertebral column. Clin Orthop Relat Res 1976;115:6-21.
3. Hirsch C, Schajowicz F. Studies on structural changes in the lumbar annulus fibrosus. Acta Orthop Scand 1953;22:184-231.
4. Virri J, Grönbald M, Savikko J, et al. Prevalence, morphology, and topography of blood vessels in herniated disc tissue. A comparative immunocytochemical study. Spine 1996;21:1856-63.
5. Kauppila LI, Finland H. Ingrowth of blood vessels in disc degeneration. J Bone Joint Surg 1995;77-a:26-31.
6. Repanti M, Korovessis PG, Stamatakis MV, et al. Evolution of disc degeneration in lumbar spine: A comparative histological study between herniated and postmortem retrieved disc specimens. J Spinal Disord 1998;11:41-5.
7. Ozaki T, Muro T, Ito S, et al. Neovascularisation of the outermost area of herniated lumbar intervertebral discs. J Orthop Sci 1999;4:286-92.
8. Yasuma T, Arai K, Yamauchi Y. The histology of lumbar intervertebral disc herniation: The significance of small blood vessels in the extruded tissue. Spine 1993;18:1761-5.
9. Roberts S, Caterson B, Menage J, et al. Matrix metalloproteinases and aggrecanase: Their role in disorders of the human intervertebral disc. Spine 2000;25:3005-13.
10. Johnson WEB, Evans H, Menage J, et al. Immunohistochemical detection of Schwann cells in innervated and vascularized human intervertebral discs. Spine 2001;26:2550-7.
11. Ashton IK, Roberts S, Jaffray DC, et al. Neuropeptides in the human intervertebral disc. J Orthop Res 1994;12:186-92.
12. Freemont AJ, Watkins A, Le Maitre C, et al. Nerve growth factor expression and innervation of the painful intervertebral disc. J Pathol 2002;197: 286-92.
13. Holm S, Nachemson A. Nutrition of the intervertebral disc: acute effects of cigarette smoking. An experimental animal study. Ups J Med Sci 1988;93:91-9.
14. Urban JPG, Roberts S. Degeneration of the intervertebral disc. Arthritis Res Ther 2003;5:120-30.
15. Minamide A, Hashizume H, Yoshida M, et al. Effects of basic fibroblasts growth factor on spontaneous resorption of herniated discs. An experimental study in rabbits. Spine 1999;24:940-5.
16. Haro H, Kato T, Komori H, et al. Vascular endothelial growth factor (VEGF)-induced angiogenesis in herniated disc resorption. J Orthop Res 2002;20:409-15.
17. Freemont AJ, Peacock TE, Goupille P, et al. Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 1997;350:178-81.
18. Tolonen J, Gronblad M, Virri J, et al. Basic fibroblast growth factor immunoreactivity in blood vessels and cells of disc herniations. Spine 1995;20: 271-6.
19. Tolonen J, Gronblad M, Virri J, et al. Platelet-derived growth factor and vascular endothelial growth factor expression in disc herniation tissue: An immunohistochemical study. Eur Spine J 1997;6:63-9.
20. Tolonen J, Gronblad M, Virri J, et al. Transforming growth factor β receptor induction in herniated intervertebral disc tissue: An immunohistochemical study. Eur Spine J 2001;10:172-6.
21. Specchia N, Pagnotta A, Toesca A, et al. Cytokines and growth factors in the protruded intervertebral disc of the lumbar spine. Eur Spine J 2002; 11:145-51.
22. Ashton IK, Walsh DA, Polak JM, et al. Substance P in intervertebral discs. Binding sites on vascular endothelium of the human annulus fibrosus. Acta Orthop Scand 1994;65:635-9.
23. Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: Role of the HIF system. Nat Med 2004;9:677-84.
24. Goerges AL, Nugent MA. pH regulates vascular endothelial growth factor binding to fibronectin: A mechanism for control of extracellular matrix storage and release. J Biol Chem 2004;279:2307-15.
25. Goerges AL, Nugent MA. Regulation of vascular endothelial growth factor binding and activity by extracellular pH. J Biol Chem 2003;278:19158-25.
26. Hayami T, Funaki H, Mitui K, et al. Expression of the cartilage derived anti-angiogenic factor chondromodulin-I decreases in the early stage of experimental osteoarthritis. J Rheumatol 2003;30:2207-17.
27. Takao T, Iwaki T, Kondo J, et al. Immunohistochemistry of chondromodulin-I in the human intervertebral disc with special reference to the degenerative changes. Histochem J 2000;32:545-50.
28. Sottile J. Regulation of angiogenesis by extracellular matrix. Biochim Biophys Acta 2004;1654:13-22.
29. Iivanainen E, Kahari VM, Heino J, et al. Endothelial cell-matrix interactions. Microsc Res Tech 2003;60:13-22.
30. Melrose J, Roberts S, Smith S, et al. Increased nerve and blood vessel in-growth associated with proteoglycan depletion in an ovine anular lesion model of experimental disc degeneration. Spine 2002;27:1278-85.
31. Fenwick SA, Gregg PJ, Rooney P. Osteoarthritic cartilage loses its ability to remain avascular. Osteoarthritis Cartilage 1999;7:441-52.
32. Smith JO, Oreffo RO, Clarke NM, et al. Changes in the antiangiogenic properties of articular cartilage in osteoarthritis. J Orthop Sci 2003;8: 849-57.
33. Lyons G, Eisenstein SM, Sweet MBE. Biochemical changes in intervertebral disc degeneration. Biochim Biophys Acta 1981;673:443-53.
34. Pearce RH, Grimmer BJ, Adams ME. Degeneration and the chemical composition of the human lumbar intervertebral disc. J Orthop Res 1987; 5:198-205.
35. Tertti M, Paajanen H, Laato M, et al. Disc degeneration in magnetic resonance imaging: A comparative biochemical, histologic, and radiologic study in cadaver spines. Spine 1991;16:629-34.
36. Johnson WEB, Caterson B, Eisenstein SM, et al. Human intervertebral disc aggrecan inhibits nerve growth in vitro. Arthritis Rheum 2002;46:2658-64.
37. Ades EW, Candal FJ, Swerlick RA, et al. HMEC-1: Establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol 1992;99:683-90.
38. Edgell CJ, McDonald CC, Graham JB. Permanent cell line expressing human factor VIII-related antigen established by hybridisation. Proc Natl Acad Sci U S A 1983;80:3734-7.
39. Unger RE, Krump-Konvalinkova V, Peters K, et al. In vitro expression of the endothelial phenotype: A comparative study of primary isolated cells and eel lines, including the novel cell line HPMEC-ST1.6R. Microvasc Res 2002;64: 384-97.
40. Donohue PJ, Jahnke MR, Blaha JD, et al. Characterization of link protein(s) from human intervertebral-disc tissues. Biochem J 1988;251:739-47.
41. Jahnke MR, McDevitt CA. Proteoglycans of the human intervertebral disc. Biocbem J 1988;251:347-56.
42. Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 1986;883:173-7.
43. Rees SG, Flannery CR, Little CB, et al. Catabolism of aggrecan, decorin and biglycan in tendon. Biochem J 2000;350:181-8.
44. Mosmann T. Rapid colorimetric assay for growth and survival; application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
45. Coppes MH, Marani E, Thomeer RT, et al. Innervation of annulus fibrosis in low back pain. Lancet 1990;336:189-90.
46. Coppes MH, Marani E, Thomeer RT, et al. Innervation of "Painful" lumbar discs. Spine 1997;22:2342-50.
47. Klimaschewski L, Nindl W, Feurle J, et al. Basic fibroblast growth factor isoforms promote axonal elongation and branching of adult sensory neurons in vitro. Neuroscience 2004;126:347-53.
48. Aoki Y, Ohtori S, Takahashi K, et al. Innervation of the lumbar intervertebral disc by nerve growth factor-dependent neurons related to inflammatory pain. Spine 2004;29:1077-81.