Are small changes in serum creatinine an important risk factor?

Current Opinion in Nephrology and Hypertension

Volumn 14, Issue 3, 2005, Pages 265-270

  Praught, Melanie L ^a   Shlipak, Michael G ^a,b,c  

^a SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cardiac surgery; Cardiovascular disease; Coronary artery disease; Creatinine; Heart failure; Renal function

Indexed keywords

CREATININE;

CARDIORENAL SYNDROME; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CORONARY ARTERY DISEASE; CREATININE BLOOD LEVEL; FOLLOW UP; HEART DISEASE; HEART FAILURE; HEART INFARCTION; HEART SURGERY; HOSPITALIZATION; HUMAN; KIDNEY DISEASE; KIDNEY FUNCTION; MORTALITY; PRIORITY JOURNAL; REVIEW;

EID: 18844401341     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mnh.0000165894.90748.72     Document Type: Review

References (18)

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5. Shlipak MG, Stehman-Breen C, Vittinghoff E, et al. Creatinine levels and cardiovascular events in women with heart disease: do small changes matter? Am J Kidney Dis 2004; 43:37-44. In this large cohort of ambulatory women with coronary artery disease, 4-year change in creatinine levels did not independently predict coronary disease risk.
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11. Lassnigg A, Schmidlin D, Mouhieddine M, et al. Minimal changes of serum creatinine predict prognosis in patients after cardiothoracic surgery: a prospective cohort study. J Am Soc Nephrol 2004; 15:1597-1605. Comprehensive analysis demonstrating a 'J-shaped' association between varying levels of change in creatinine with mortality after cardiac surgery.
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14. Butler J, Forman DE, Abraham WT, et al. Relationship between heart failure treatment and development of worsening renal function among hospitalized patients. Am Heart J 2004; 147:331-338. This observational study found an association between the use of calcium channel blockers and loop diuretics with incidence of worsening renal function in heart failure patients.
15. Gottlieb SS, Abraham W, Butler J, et al. The prognostic importance of different definitions of worsening renal function in congestive heart failure. J Card Fail 2002; 8:136-141.
16. Smith GL, Vaccarino V, Kosiborod M, et al. Worsening renal function: what is a clinically meaningful change in creatinine during hospitalization with heart failure? J Card Fail 2003; 9:13-25. This analysis found a linear relationship between creatinine rise and adverse outcomes following hospitalization for heart failure.
17. Shlipak MG, Massie BM. The clinical challenge of cardiorenal syndrome. Circulation 2004; 110:1514-1517. This editorial briefly summarizes the current understanding about treating patients with combined heart failure and worsened renal function, a scenario that has been dubbed the cardiorenal syndrome.
18. Wang DJ, Dowling TC, Meadows D, et al. Nesiritide does not improve renal function in patients with chronic heart failure and worsening serum creatinine. Circulation 2004; 110:1620-1625. The first clinical trial devoted to testing a treatment for patients presenting with heart failure and worsened renal function.