Neutrophil transepithelial migration: Role of toll-like receptors in mucosal inflammation

Memorias do Instituto Oswaldo Cruz

Volumn 100, Issue SUPPL. 1, 2005, Pages 191-198

  Reaves, Titus A ^a   Chin, Alex C ^a   Parkos, Charles A ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell surface proteins; Ephitelium; Mucosal inflammation; Neutrophil migration; Toll like receptor

Indexed keywords

AUTACOID; BETA2 INTEGRIN; CD11B ANTIGEN; CD18 ANTIGEN; CD47 ANTIGEN; FORMYLMETHIONYLLEUCYLPHENYLALANINE; LIGAND; LIPOPOLYSACCHARIDE; PROTEIN DERIVATIVE; PROTEIN JAM; PROTEOGLYCAN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ACUTE CHOLECYSTITIS; BACTERIAL INFECTION; BRONCHIECTASIS; BRONCHITIS; BRONCHOPNEUMONIA; CELL INTERACTION; CELL MIGRATION; CHOLANGITIS; CONFERENCE PAPER; CROHN DISEASE; CYSTIC FIBROSIS; CYSTITIS; ENTEROCOLITIS; EPITHELIUM; EPITHELIUM CELL; EXPOSURE; FUCOSYLATION; GASTRITIS; GASTROINTESTINAL DISEASE; HEPATOBILIARY SYSTEM INFLAMMATION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IN VITRO STUDY; INTESTINE; LEUKOCYTE ADHERENCE; LEUKOCYTE FUNCTION; MEDIATOR; MICROBIAL IMMUNITY; MICROORGANISM; MOLECULAR BIOLOGY; MOLECULAR RECOGNITION; MUCOSA INFLAMMATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOPHYSIOLOGY; POLARIZATION; POLYMORPHONUCLEAR CELL; PROTEIN EXPRESSION; PROTEIN FAMILY; PYELONEPHRITIS; REGULATORY MECHANISM; RESPIRATORY TRACT INFLAMMATION; SYMPTOM; TRANSCRIPTION REGULATION; ULCERATIVE COLITIS; UPREGULATION; URINARY TRACT INFLAMMATION;

BACTERIA (MICROORGANISMS);

EID: 18844398585     PISSN: 00740276     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0074-02762005000900033     Document Type: Conference Paper

References (83)

1. Abreu MT, Arnold ET, Thomas LS, Gonsky R, Zhou Y, Hu B, Arditi M 2002. TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. J Biol Chem 277: 20431-20437.
2. Abreu MT, Thomas LS, Arnold ET, Lukasek K, Michelsen KS, Arditi M 2003. TLR signaling at the intestinal epithelial interface. J Endotoxin Res 9: 322-330.
3. Agace WW, Patarroyo M, Svensson M, Carlemalm E, Svanborg C 1995. Escherichia coli induces transuroepithelial neutrophil migration by an intercellular adhesion molecule-1-dependent mechanism. Infect Immun 63: 4054-4062.
4. Arrate MP, Rodriguez JM, Tran TM, Brock TA, Cunningham SA 2001. Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor. J Biol Chem 276: 45826-45832.
5. Aurrand-Lions M, Duncan L, Ballestrem C, Imhof BA 2001a. JAM-2, a novel immunoglobulin superfamily molecule, expressed by endothelial and lymphatic cells. J Biol Chem 276: 2733-2741.
6. Aurrand-Lions M, Johnson-Leger C, Wong C, Du Pasquier L, Imhof BA 2001b. Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members. Blood 98: 3699-3707.
7. Backhed F, Hornef M 2003. Toll-like receptor 4-mediated signaling by epithelial surfaces: necessity or threat? Microbes Infect 5: 951-959.
8. Balsam LB, Liang TW, Parkos CA 1998. Functional mapping of CD11b/CD18 epitopes important in neutrophil-epithelial interactions: a central role of the I domain. J Immunol 160: 5058-5065.
9. Barton ES, Forrest JC, Connolly JL, Chappell JD, Liu Y, Schnell FJ, Nusrat A, Parkos CA, Dermody TS 2001. Junction adhesion molecule is a receptor for reovirus. Cell 104: 441-451.
10. Ben-Baruch A, Michiel DF, Oppenheim JJ 1995. Signals and receptors involved in recruitment of inflammatory cells. J Biol Chem 270: 11703-11706.
11. Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithiras A, Hong JS, Horowitz MS, Crowell RI, Finberg RW 1997. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5. Science 283: 2080-2082.
12. Brown E 2001. Integrin-associated protein (CD47): an unusual activator of G protein signaling. J Clin Invest 107: 1499-1500.
13. Cario E, Podolsky DK 2000. Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 68: 7010-7017.
14. Cario E, Rosenberg IM, Brandwein LP, Beck L, Reinecker HC, Podolsky DK 2000. Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors. J Immunol 164: 966-972.
15. Cohen CJ, Shieh JT, Pickles RJ, Okegawa T, Hsieh JT, Bergelson JM 2001. The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. Proc Natl Acad Sci USA 98: 15191-15196.
16. Colgan SP, Parkos CA, McGuirk D, Brady HR, Papayianni AA, Frendl G, Madara JL 1995. Receptors involved in carbohydrate binding modulate intestinal epithelial-neutrophil interactions. J Biol Chem 270: 10531-10539.
17. Cunningham SA, Arrate MP, Rodriguez JM, Bjercke RJ, Vanderslice P, Morris AP, Brock TA 2000. A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions. J Biol Chem 275: 34750-34756.
18. Diamond MS, Alon R, Parkos CA, Quinn MT, Springer TA 1995. Heparin is an adhesive ligand for the leukocyte integrin Mac-1 (CD11b/CD1). J Cell Biol 130: 1473-1482.
19. Diamond MS, Staunton DE, de Fougerolles AR, Stacker SA, Garcia-Aguilar J, Hibbs ML, Springer TA 1990. ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). J Cell Biol 111: 3129-3139.
20. Ebnet K, Schulz CU, Meyer Zu Brickwedde MK, Pendl GG, Vestweber D 2000. Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1. J Biol Chem 275: 27979-27988.
21. Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu Brickwedde MK, Ohno S, Vestweber D 2001. The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). Embo J 20: 3738-3748.
22. Edens HA, Levi BP, Jaye DL, Walsh S, Reaves TA, Turner JR, Nusrat A, Parkos CA 2002. Neutrophil transepithelial migration: evidence for sequential, contact- dependent signaling events and enhanced paracellular permeability independent of transjunctional migration. J Immunol 169: 476-486.
23. Fan J, Malik AB 2003. Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors. Nat Med 9: 315-321.
24. Fenton MJ, Golenbock DT 1998. LPS-binding proteins and receptors. J Leukoc Biol 64: 25-32.
25. Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL 2001. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J Immunol 167: 1882-1885.
26. Greenberg S, Grinstein S 2002. Phagocytosis and innate immunity. Curr Opin Immunol 14: 136-145.
27. Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S 2002. Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. J Biol Chem 277: 455-461.
28. Hausmann M, Kiessling S, Mestermann S, Webb G, Spottl T, Andus T, Scholmerich J, Herfarth H, Ray K, Falk W, Rogler G 2002. Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology 122: 1987-2000.
29. Hawker PC, McKay JS, Turnberg LA 1980. Electrolyte transport across colonic mucosa from patients with inflammatory bowel disease. Gastroenterology 79: 508-511.
30. Hayashi F, Means TK, Luster AD 2003. Toll-like receptors stimulate human neutrophil function. Blood 102: 2660-2669.
31. Hecht G 1999. Innate mechanisms of epithelial host defense: spotlight on intestine. Am J Physiol 277: C351-358.
32. Hershberg RM 2002. The epithelial cell cytoskeleton and intracellular trafficking. V. Polarized compartmentalization of antigen processing and Toll-like receptor signaling in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 283: G833-839.
33. Hirabayashi S, Tajima M, Yao I, Nishimura W, Mori H, Hata Y 2003. JAM4, a Junctional Cell Adhesion Molecule Interacting with a Tight Junction Protein, MAGI-1. Mol Cell Biol 23: 4267-4282.
34. Hornef MW, Frisan T, Vandewalle A, Normark S, Richter-Dahlfors A 2002. Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. J Exp Med 195: 559-570.
35. Jiang P, Lagenaur CF, Narayanan V 1999. Integrin-associated protein is a ligand for the P84 neural adhesion molecule. J Biol Chem 274: 559-562.
36. Kopp E, Medzhitov R 2003. Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol 15: 396-401.
37. Koyama S, Rennard SI, Leikauf GD, Shoji S, von Essen S, Claasen L, Robbins RA 1991. Endotoxin stimulates bronchial epithelial cells to release chemotactic factors for neutrophils: a potential mechanism for neutrophil recruitment, cytotoxicity, and inhibition of proliferation in bronchial inflammation. J Immunol 147: 4293-4301.
38. Liang TW, Chiu HH, Gurney A, Sidle A, Tumas DB, Schow P, Foster J, Klassen T , Dennis K, DeMarco RA, Pham T, Frantz G, Fong S. 2002. Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3. J Immunol 168: 1618-1626.
39. Lindberg FP, Bullard DC, Caver TE, Gresham HD, Beaudet AL, Brown EJ 1996. Decreased resistance to bacterial infection and granulocyte defects in iap-deficient mice. Science 274: 795-798.
40. Lindberg FP, Gresham HD, Schwarz E, Brown EJ 1993. Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding. J Cell Biol 123: 485-496.
41. Liu Y, Buhring HJ, Zen K, Burst SL, Schnell FJ, Williams IR, Parkos CA 2002. Signal regulatory protein (SIRPalpha), a cellular ligand for CD47, regulates neutrophil transmigration. J Biol Chem 277: 10028-10036.
42. Liu Y, Merlin D, Burst SL, Pochet M, Madara JL, Parkos CA 2001. The role of CD47 in neutrophil transmigration. Increased rate of migration correlates with increased cell surface expression of CD47. J Biol Chem 276: 40156-40166.
43. Liu Y, Nusrat A, Schnell FJ, Reaves TA, Walsh S, Pochet M, Parkos CA 2000. Human junction adhesion molecule regulates tight junction resealing in epithelia. J Cell Sci 113: 2363-2374.
44. Liu Y, Shaw SK, Ma S, Yang L, Luscinskas FW, Parkos CA 2004. Regulation of leukocyte transmigration: cell surface interactions and signaling events. J Immunol 172: 7-13.
45. Lorenz E, Patel DD, Hartung T, Schwartz DA 2002. Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. Infect Immun 70: 4892-4896.
46. Madara JL, Patapoff TW, Gillece-Castro B, Colgan SP, Parkos CA, Delp C, Mrsny RJ 1993. 5′-AMP is the neutrophil-derived paracrine factor that ilicits chloride secretion from T84 epithelial monolayers. J Clin Invest 91: 2320-2325.
47. Malergue F, Galland F, Martin F, Mansuelle P, Aurrand-Lions M, Naquet P 1998. A novel immunoglobulin superfamily junctional molecule expressed by antigen presenting cells, endothelial cells and platelets. Mol Immunol 35: 1111-1119.
48. Martinez-Estrada OM, Villa A, Breviario F, Orsenigo F, Dejana E, Bazzoni G 2001. Association of junctional adhesion molecule with calcium/calmodulin- dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cells. J Biol Chem 276: 9291-9296.
49. Martin-Padura I, Lostaglio S, Schneemann M, Williams L, Romano M, Fruscella P, Panzeri C, Stoppacciaro A, Ruco L, Villa A, Simmons D, Dejana E 1998. Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Cell Biol 142: 117-127.
50. Medzhitov R, Janeway Jr CA 1997. Innate immunity: impact on the adaptive immune response. Curr Opin Immunol 9: 4-9.
51. Medzhitov R, Preston-Hurlburt P, Janeway Jr CA 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388: 394-397.
52. Milks LC, Brontoli MJ, Cramer EB 1983. Epithelial permeability and the transepithelial migration of human neutrophils. J Cell Biol 96: 1241-1247.
53. Moog-Lutz C, Cave-Riant F, Guibal FC, Breau MA, Di Gioia Y, Couraud PO, Cayre YE, Bourdoulous S, Lutz PG 2003. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeioid leukemia cells. Blood 102: 3371-3378.
54. Naik UP, Naik MU, Eckfeld K, Martin-DeLeon P, Spychala J 2001. Characterization and chromosomal localization of JAM-1, a platelet receptor for a stimulatory monoclonal antibody. J Cell Sci 114: 539-547.
55. Nash S, Stafford J, Madara JL 1987. Effects of polymorphonuclear leukocyte transmigration on barrier function of cultured intestinal epithelial monolayers. J Clin Invest 80: 1104-1113.
56. Nusrat A, Parkos CA, Liang TW, Carnes DK, Madara JL 1997. Neutrophil migration across model intestinal epithelia: monolayer disruption and subsequent events in epithelial repair. Gastroenterology 113: 1489-1500.
57. Nusrat A, Turner JR, Madara JL 2000. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol Gastrointest Liver Physiol 279: G851-857.
58. Ortega-Cava CF, Ishihara S, Rumi MA, Kawashima K, Ishimura N, Kazumori H, Udagawa J, Kadowaki Y, Kinoshita Y 2003. Strategic compartmentalization of Toll-like receptor 4 in the mouse gut. J Immunol 170: 3977-3985.
59. Ozaki H, Ishii K, Horiuchi H, Arai H, Kawamoto T, Okawa K, Iwamatsu A, Kita T 1999. Cutting edge: combined treatment of TNF-alpha and IFN-gamma causes redistribution of junctional adhesion molecule in human endothelial cells. J Immunol 163: 553-557.
60. Palmen D, van Zante A, Huang CC, Hemmerich S, Rosen SD 2000. Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells. J Biol Chem 275: 19139-19145.
61. Parkos CA 1997. Cell adhesion and migration. I. Neutrophil adhesive interactions with intestinal epithelium. Am J Physiol 273: G763-768.
62. Parkos CA, Colgan SP, Liang TW, Nusrat A, Bacarra AE, Carnes DK, Madara JL 1996. CD47 mediates post-adhesive events required for neutrophil migration across polarized intestinal epithelia. J Cell Biol 132: 437-450.
63. Parkos CA, Delp C, Arnaout MA, Madara JL 1991. Neutrophil migration across a cultured intestinal epithelium. Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction. J Clin Invest 88: 1605-1612.
64. Parsons PE, Sugahara K, Cott GR, Mason RJ, Henson PM 1987. The effect of neutrophil migration and prolonged neutrophil contact on epithelial permeability. Am J Pathol 129: 302-312.
65. Prossnitz ER, Ye RD 1997. The N-formyl peptide receptor: a model for the study of chemoattractant receptor structure and function. Pharmacol Ther 74: 73-102.
66. Ramos CD, Heluy-Neto NE, Ribeiro RA, Ferreira SH, Cunha FQ 2003. Neutrophil migration induced by IL-8-activated mast cells is mediated by CINC-1. Cytokine 21: 214-223.
67. Reed KA, Hobert ME, Kolenda CE, Sands KA, Rathman M, O'Connor M, Lyons S, Gewirtz AT, Sansonetti PJ, Madara JL 2002. The Salmonella typhimurium flagellar basal body protein FliE is required for flagellin production and to induce a proinflammatory response in epithelial cells. J Biol Chem 277: 13346-13353.
68. Sabroe I, Read RC, Whyte MK, Dockrell DH, Vogel SN, Dower SK 2003. Toll-like receptors in health and disease: complex questions remain. J Immunol 171: 1630-1635.
69. Santoso S, Sachs UJ, Kroll H, Linder M, Ruf A, Preissner KT, Chavakis T 2002. The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. J Exp Med 196: 679-691.
70. Sobocka MB, Sobocki T, Banerjee P, Weiss C, Rushbrook JI, Norin AJ, Hartwig J, Salifu MO, Markell MS, Babinska A, Ehrlich YH, Kornecki E 2000. Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. Blood 95: 2600-2609.
71. Stofega MR, Argetsinger LS, Wang H, Ullrich A, Carter-Su C 2000. Negative regulation of growth hormone receptor/JAK2 signaling by signal regulatory protein alpha. J Biol Chem 275: 28222-28229.
72. Strohmeier GR, Lencer WI, Patapoff TW, Thompson LF, Carlson SL, Moe SJ, Carnes D, Mrsny RJ, Madara JL 1997. Surface expression, polarization and functional significance of CD73 in human intestinal epithelia. J Clin Invest 99: 2588-2601.
73. Strohmeier GR, Reppert SM, Lencer WI, Madara JL 1995. The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia. J Biol Chem 270: 2387-2394.
74. Takeda K, Kaisho T, Akira S 2003. Toll-like receptors. Annu Rev Immunol 21: 335-376.
75. Tavares-Murta BM, Zaparoli M, Ferreira RB, Silva-Vergara ML, Oliveira CH, Murta EF, Ferreira SH, Cunha FQ 2002. Failure of neutrophil chemotactic function in septic patients. Crit Care Med 30: 1056-1061.
76. Tosi MF, Stark JM, Smith CW, Hamedani A, Gruenert DC, Infeld MD 1992. Induction of ICAM-1 expression on human airway epithelial cells by inflammatory cytokines: effects on neutrophil-epithelial cell adhesion. Am J Resp Cell Mol Biol 7: 214-221.
77. Viriyakosol S, Mathison JC, Tobias PS, Kirkland TN 2000. Structure-function analysis of CD14 as a soluble receptor for lipopolysaccharide. J Biol Chem 275: 3144-3149.
78. Weiland JE, Davis WB, Holter JF, Mohammed JR, Dorinsky PM, Gadek JE. 1986. Lung neutrophils in the adult respiratory distress syndrome. Clinical and pathophysiologic significance. Am Rev Respir Dis 133: 218-225.
79. Williams LA, Martin-Padura I, Dejana E, HoggN, Simmons DL 1999. Identification and characterisation of human Junctional Adhesion Molecule (JAM). Mol Immunol 36: 1175-1188.
80. Zen K, Babbin BA, Liu Y, Whelan JB, Nusrat A, Parkos CA 2004. JAM-C is a component of desmosomes and a ligand for CD11b/CD18 - mediated neutrophil transepithelial migration. Mol Biol Cell 15: 3926-3937.
81. Zen K, Parkos CA 2003. Leukocyte-epithelial interactions. Curr Opin Cell Biol 15: 557-564.
82. Zen K, Liu Y, Cairo D, Parkos CA 2002. CD11b/CD18-dependent interactions of neutrophils with intestinal epithelium are mediated by fucosylated proteoglycans. J Immunol 169: 5270-5278.
83. Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, Ghosh S 2004. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 303: 1522-1526.