Structural insights in platelet receptor synergism-antiplatelet therapy in post-ischemic cerebrovascular events

Blood Cells, Molecules, and Diseases

Volumn 34, Issue 3, 2005, Pages 248-256

  Lahiri, Prabir ^a   Chaudhuri, Utpal ^a   Chattopadhyay, Arnab ^a   Chakraborty, Prantar ^a   Mandal, Dipes ^a   Dasgupta, Anjan Kr ^b  

^a MEDICAL COLLEGE AND HOSPITAL   (India)

^b UNIVERSITY OF CALCUTTA   (India)

Author keywords

Clopidogrel; Homology modeling; Platelet aggregation deaggregation; Stroke; Yohimbine hydrochloride

Indexed keywords

ADENOSINE DIPHOSPHATE; ADRENALIN; ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; CLOPIDOGREL; DRUG RECEPTOR; PURINE RECEPTOR; YOHIMBINE;

ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; DOSE RESPONSE; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG RESPONSE; DRUG SPECIFICITY; HUMAN; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR AFFINITY; SEQUENCE HOMOLOGY; THROMBOCYTE AGGREGATION; UNINDEXED SEQUENCE;

ADENOSINE DIPHOSPHATE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; DRUG RESISTANCE; DRUG SYNERGISM; EPINEPHRINE; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RECEPTOR CROSS-TALK; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, PURINERGIC P2; TICLOPIDINE;

EID: 18844372831     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2005.01.003     Document Type: Article

References (26)

1. Antiplatelet Trialists' Collaboration Secondary prevention of vascular disease by prolonged antiplatelet treatment BMJ 296 1988 320 331
2. The Steering Committee of the Physicians' Health Study Research Group Final report on the aspirin component of the ongoing Physicians' Health Study N. Engl. J. Med. 321 1989 129 135
3. Antiplatelet Trialists' Collaboration Collaborative overview of randomized trials of antiplatelet therapy: I. Prevention of death, myocardial infarction and stroke by prolonged antiplatelet therapy in various categories of patients BMJ 308 1994 81 106
4. The EPIC Investigators Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high risk angioplasty N. Engl. J. Med. 330 1994 956 961
5. K. Schror Antiplatelet drugs: a comparative review Drugs 50 1995 7 28
6. A. Gaardner, J. Jonsen, S. Laland, A. Hellem, and P.A. Owen Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets Nature 192 1961 531 532
7. G.V.R. Born Adenosine diphosphate as a mediator of platelet aggregation in vivo: an editorial point of view Circulation 72 1985 741 742
8. CAPRIE Steering Committee A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE) Lancet 348 1996 1329 1339
9. M. Stone, L. Shore-Lesserson, G. Martinelli, and S. Maayani The antiaggregatory effects of clopidogrel are due to enhancement of platelet deaggregation Anesth. Analg. 90 2000 12
10. S. Maayani, T. Schwarz, B. Craddock-Royal, and T.M. Tagliente Activation of alpha2A-adrenoceptor mediates deceleration of deaggregation component of the responser to ADP or 5-HT in human platelets in vitro Platelets 12 2001 359 375
11. T. O'Malley, P. Langhorne, and R.A. Elton Platelet size in stroke patients Stroke 26 1995 995 999
12. P. Lahiri, A.K. Dasgupta, S.N. Ray, S. Saha, P. Mukherjee, U. Chaudhuri, Insensitivity to the a2-adrenergic receptor blocker yohimbine hydrochloride and occurrence of spontaneous platelet macroaggregation (SPMA) in diabetes. Platelets (in press).
13. M. Huynen, T. Doerks, F. Eisenhaber, C. Orengo, S. Sunyaev, Y.P. Yuan, and P. Bork Homology-based fold prediction for Mycoplasma genitalium proteins J. Mol. Biol. 280 1998 323 326
14. W. Humphrey, A. Dalke, and K. Schulten VMD-visual molecular dynamics J. Mol. Graphics 14 1996 33 38
15. E. Pongracz Measurement of platelet aggregation during antiplatelet therapy in ischemic stroke Clin. Hemorheol. Microcirc. 30 2004 237 242
16. C. Gachet ADP receptors of platelets and their inhibition Thromb. Haemost. 86 2001 222 232
17. W.R. Figures, M.L. Scarce, Y. Watchfogel, J. Chen, R.F. Colman, and R.W. Colman Platelet ADP receptor and alpha-2 adreniceptor interaction. Evidence for an ADP requirement for epinephrine-induced platelet activation and an influence of epinephrine on ADP binding J. Biol. Chem. 261 1986 5981 5986
18. J.A. Grant, and M.C. Scrutton Positive interaction between agonists in the aggregation response of human blood platelets: interaction between ADP, adrenaline and vasopressin Br. J. Haemtol. l44 1980 109 125
19. G. Anfossi, and M. Trovati Role of catecholamines in platelet function: pathophysiological and clinical significance Eur. J. Clin. Invest. 26 1996 353 370
20. I. Muller, F. Besta, C. Schulz, S. Massberg, A. Schonig, and M. Gawaz Prevalence of clopidogrel nonresponders among patients with stable angina pectoris scheduled for elective coronary stent placement Thromb. Haemost. 89 2003 783 787
21. N.Y. Lam, T.H. Rainer, M.H. Ng, Y. Leung, and R.A. Cocks Effect of stress hormones on the expression of fibrinogen-binding receptors in platelets Resuscitation 55 2002 277 283
22. K. Schror, A.A. Weber, and T. Hohlfeld Clopidogrel resistance Thromb. Haemost. 92 2004 229 231
23. S. Karpatkin, and N. Strick Heterogeneity of human platelets: V. Differences in glycolytic and related enzymes with possible relation to platelet age J. Clin. Invest. 51 1972 1235 1243
24. L. Corash, H. Tau, and H.R. Gralnick Heterogeneity of human whole blood platelet subpopulations: I. Relationship between buoyant density, cell volume, and ultrastructure Blood 49 1977 71 87
25. L.F. Agnati, S. Ferré, C. Lluis, R. Franco, and K. Fuxe Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons Pharmacol. Rev. 55 2003 509 550
26. D.E. Wachsman, J.P. Kavaler, I.P. Sugar, E.N. Schachter, W. Gonsiorek, and S. Maayani Kinetic studies of desensitization and resensitization of the relaxation response to beta-2 adrenoceptor agonists in isolated guinea pig trachea J. Pharmacol. Exp. Ther. 280 1997 332 345