Human thyrotropin (TSH) variants designed by site-directed mutagenesis block TSH activity in vitro and in vivo

Endocrinology

Volumn 146, Issue 6, 2005, Pages 2845-2850

  Azzam, Naiel ^a   Bar Shalom, Rinat ^a   Kraiem, Zaki ^a   Fares, Fuad ^a  

^a CARMEL MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

FORSKOLIN; HORMONE DERIVATIVE; THYROID HORMONE; THYROTROPIN; THYROTROPIN RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HORMONE ACTION; HORMONE DETERMINATION; HORMONE RECEPTOR INTERACTION; HORMONE SYNTHESIS; HYPERTHYROIDISM; NONHUMAN; OVARY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; THYROID HORMONE RELEASE;

ANIMALS; ANTIBODIES; CHO CELLS; CRICETINAE; GENE THERAPY; HUMANS; HYPERTHYROIDISM; MALE; MICE; MICE, INBRED BALB C; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; THYROTROPIN; TRANSFECTION;

EID: 18844371761     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2005-0012     Document Type: Article

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