Detection of PML-RARα in patients with APL during follow-up period

Chinese Medical Journal

Volumn 109, Issue 4, 1996, Pages 295-299

  Wu, Xingzhong ^a   Lin, Jianwen ^c   Yang, Zhicheng ^b   Wang, Xuewen ^c   Qian, Xiaoping ^b   Ying, Jiangshan ^b   Yu, Yaping ^b   Qin, Shukui ^d   Lou, Jingwei ^b   Yao, Haiqin ^b   Chen, Huili ^a  

^a FUDAN UNIVERSITY   (China)

^b JINLING HOSPITAL   (China)

^c Nanjing Rear Service Department   (China)

^d Nanjing 81 Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID RECEPTOR; RETINOIC ACID RECEPTOR ALPHA;

ADOLESCENT; ADULT; ARTICLE; CHROMOSOME 15; CHROMOSOME 17; FEMALE; FOLLOW UP; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PROMYELOCYTIC LEUKEMIA; RECURRENT DISEASE;

ADOLESCENT; ADULT; BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 15; CHROMOSOMES, HUMAN, PAIR 17; FEMALE; FOLLOW-UP STUDIES; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RECEPTORS, RETINOIC ACID; RECURRENCE; TRANSCRIPTION, GENETIC; TRANSLOCATION, GENETIC;

EID: 18744420885     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Larson RA, Kondo K, Vardiman JW, et al. Evidence for 15:17 translocation in every patient with acute promyelocytic leukemia. Am J Med 1984; 76:827.
2. Chen SJ, Zhu YJ, Tong HJ, et al. Rearrangement in the second intron of the RARA gene is present in a large majority of patients with acute promyelocytic leukemia and is used as a molecular marker for retinoic acid-induced leukemic cell differentiation. Blood 1991; 78:2696.
3. Diverio D, Lo coco F, D'Adamo F, et al. Identification of DNA rearrangements at the retinoic acid receptor-alpha (RAR-alpha) locus in all patients with acute promyelocytic leukaemia (APL) and mapping of APL breakpoints within the RAR-alpha second intron. Italian Cooperative Study Group "GIMEMA". Blood 1992; 79:3331.
4. Nichols J, Nimer SD. Transcription factors, translocation and leukemia. Blood 1992; 80:2953.
5. Goddard AD, Borrow J, Freemont PS, et al. Characterization of a novel zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia. Science 1991; 254:1371.
6. Borrow J, Goddard AD, Gibbons DA, et al. Diagnosis of acute promyelocytic leukemia by RT-PCR: detection of PML-RARα and RAR-PML fusion transcripts. Br J Hematol 1992; 82:529.
7. Miller WH Jr, Kakizuka A, Frankel SR, et al. Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia. Proc Natl Acad Sci USA 1991; 89:2694.
8. Chang KS, Lu HE, Wang G, et al. The t(15;17) breakpoint in acute promyelocytic leukemia cluster within two different sites of the myl gene: targets for the detection of minimal residual disease by the polymerase chain reaction. Blood 1992; 79:554.
9. Chang KS, Stass SA, Chu DT, et al. Characterization of fusion cDNA (RAR/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia. Mol Cell Biol 1992; 12:800.
10. Chomczybski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol- chloroform extraction. Analytical Biochem 1987; 162:156.
11. Chen SJ, Chen Z, Chen A, et al. Occurrence of distinct PML-RAR-alpha fusion gene isoform in patients with acute promyelocytic leukemia detected by reverse transcriptase/ polymerase chain reaction. Oncogene 1992; 7:1223.
12. Lo Coco F, Diverio D, Pandilfi PP, et al. Molecular evaluation of residual disease as a predictor of relapse in acute promyelocytic leukemia. Lancet 1991; 340:1437.
13. Wang ZY, Chen Z, Huang W, et al. Problems existing in differentiation therapy of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA). Blood 1993; 19:633.
14. National Co-operative Study Group on Treatment of Leukemias. Clinical study on all-trans retinoic acid in the treatment of 544 patients with acute promyelocytic leukemia. Chin J Hematol 1992; 13:135.