β-Amyloid fragment 25-35 selectively damages platelets from patients with Alzheimer's disease

Annals of the New York Academy of Sciences

Volumn 977, Issue , 2002, Pages 296-302

  Casoli, Tiziana ^a   Di Stefano, Giuseppina ^a   Delfino, Alessia ^a   Solazzi, Moreno ^a   Fattoretti, Patrizia ^a   Bertoni Freddari, Carlo ^a   Guidi, Marco ^a   Scarpino, Osvaldo ^a   Giunta, Sergio ^a   Galeazzi, Luciano ^a  

^a INRCA   (Italy)

Author keywords

Aging; Alzheimer's disease (AD); Calcium; Platelets; Ultrastructure; amyloid

Indexed keywords

AMYLOID BETA PROTEIN;

AGED; ALZHEIMER DISEASE; CALCIUM MOBILIZATION; CELL AGING; CELL ULTRASTRUCTURE; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; FLUOROMETRY; HUMAN; THROMBOCYTE;

EID: 18744415134     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2002.tb04829.x     Document Type: Conference Paper

References (7)

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3. Matsushima, H., S. Shimohama et al. 1995. Reduction of platelet phospholipase C activity in patients with Alzheimer's disease. Alzheimer Dis. Assoc. Disord. 9: 213-217.
4. Mattson, M.P., B. Cheng et al. 1992. β-Amyloid peptides destabilize calcium homeostasis and render cortical neurons vulnerable to excitotoxicity. J. Neurosci. 12: 376-389.
5. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440-3450.
6. Galeazzi, L., T. Casoli et al. 2000. β-Amyloid fragment 25-35 induces changes in cytosolic free calcium in human platelets. Ann. N.Y. Acad. Sci. 903: 451-456.
7. Sevush, S., W. Jy et al. 1998. Platelet activation in Alzheimer's disease. Arch. Neurol. 55: 530-536.