Ancient origin of the CAG expansion causing Huntington disease in a Spanish population

Human Mutation

Volumn 25, Issue 5, 2005, Pages 453-459

  García Planells, Javier ^a   Burguera, Juan A ^b   Solís, Pilar ^b   Millán, José M ^b   Ginestar, Damián ^c   Palau, Francesc ^a,d   Espinós, Carmen ^a  

^a INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^b HOSPITAL UNIVERSITARIO LA FE   (Spain)

^c UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^d NONE   (Spain)

Author keywords

Allele age; CAG trinucleotide repeat; Founder effect; HD; Huntingtin; Huntington disease

Indexed keywords

ARTICLE; CONTROLLED STUDY; GENE MUTATION; GEOGRAPHIC DISTRIBUTION; HAPLOTYPE; HUMAN; HUNTINGTON CHOREA; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; POPULATION RESEARCH; PRIORITY JOURNAL; SEGREGATION ANALYSIS; SHORT TANDEM REPEAT;

ALLELES; DNA MUTATIONAL ANALYSIS; EVOLUTION, MOLECULAR; FOUNDER EFFECT; GEOGRAPHY; HAPLOTYPES; HUMANS; HUNTINGTON DISEASE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PHYSICAL CHROMOSOME MAPPING; SPAIN; TRINUCLEOTIDE REPEAT EXPANSION;

VALENCIA;

EID: 18744410962     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/humu.20167     Document Type: Article

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