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Volumn 11, Issue 10, 2005, Pages 2929-2945

The structure of hormaomycin and one of its all-peptide aza- analogues in solution: Syntheses and biological activities of new hormaomycin analogues

Author keywords

Amino acids; NMR spectroscopy; Peptidcs; Structure elucidation; Synthetic methods

Indexed keywords

AMINO ACIDS; CHEMICAL BONDS; CHROMATOGRAPHIC ANALYSIS; CONFORMATIONS; CRYSTALLIZATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS; SYNTHESIS (CHEMICAL);

EID: 18744406740     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/chem.200400977     Document Type: Article
Times cited : (10)

References (39)
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    • were indeed erroneous in this respect
    • The formula 1 as presented here depicts the correct absolute configuration in the (S)-isoleucine (He) moiety. The formulas in our recently published corrigendum in Chem. Eur. J. 2004, 10, 5568, were indeed erroneous in this respect.
    • (2004) Chem. Eur. J. , vol.10 , pp. 5568
  • 10
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    • B. D. Zlatopolskiy, M. Radzom, A. Zeeck, A. de Meijere, unpublished results
    • c)B. D. Zlatopolskiy, M. Radzom, A. Zeeck, A. de Meijere, unpublished results.
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    • note
    • 4 was also observed. On heating up to 100°C, the coalescence point was almost reached, but spectra measured at 125°C again showed the presence of several conformers; as already at this temperature the compound started to decompose, no attempts were made to measure spectra at higher temperatures.
  • 19
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    • note
    • See Supporting Information for details.
  • 22
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    • after acidic hydrolysis of the appropriate peptides. See Supporting Information for details
    • Y. Suzuki, M. Ojika, Y. Sakagami, K. Kaida, R. Fudou, T. Kameyama, J. Antibiot. 2001, 54, 22-28) after acidic hydrolysis of the appropriate peptides. See Supporting Information for details.
    • (2001) J. Antibiot. , vol.54 , pp. 22-28
    • Suzuki, Y.1    Ojika, M.2    Sakagami, Y.3    Kaida, K.4    Fudou, R.5    Kameyama, T.6
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    • (1998)
    • Geers, B.1
  • 32
    • 18744394273 scopus 로고    scopus 로고
    • note
    • [4c] Consequently, the antibiotic activities of all synthesized hormaomycin analogues against E. coli, B. subtilis, S. aureus, C. albicans were also tested. Analogue 2c was more active against 5. aureus species than hormaomycin 1. Nevertheless, its activity was lower than that of penicillin G.
  • 33
    • 18744362960 scopus 로고    scopus 로고
    • note
    • Cyclopeptides obtained after deprotection of 19a-c, epi-19a and epi-19c as well as the N-MeZ protected ring part of hormaomycin 1 were also tested (as trifluoroacetates), but were all totally inactive.
  • 34
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    • Patent US 5 580 981
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    • (2003)
    • Zlatopolski, B.D.1
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    • note
    • b) Supporting Information.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.