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Volumn 20, Issue 10, 2004, Pages 149-163

Human health risk assessment of 2-mercaptobenzothiazole in drinking water

Author keywords

2 mercaptobenzothiazole; bladder cancer; drinking water; risk assessment; total allowable concentration; transitional cell tumours

Indexed keywords

2 MERCAPTOBENZOTHIAZOLE; DRINKING WATER;

EID: 18744396703     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1191/0748233704th199oa     Document Type: Article
Times cited : (30)

References (53)
  • 2
    • 0025011584 scopus 로고
    • Chromo-some aberration and sister chromatid exchange test results with 42 chemicals
    • Also accessible through the NTP on-line study database
    • Anderson, B. E., Zeiger, E., Shelby, M. D. et al. 1990: Chromo-some aberration and sister chromatid exchange test results with 42 chemicals. Environmental and Molecular Mutagenesis 16, 55-137. Also accessible through the NTP on-line study database: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm
    • (1990) Environmental and Molecular Mutagenesis , vol.16 , pp. 55-137
    • Anderson, B.E.1    Zeiger, E.2    Shelby, M.D.3
  • 3
    • 84997902607 scopus 로고    scopus 로고
    • 2-Mercaptobenzothiazol (last accessed December 04)
    • Berufsgenossenschaft der chemischen Industrie (BUA GDCh Advisory Committee on Existing Chemicals). 2000: 2-Mercaptobenzothiazol. Number 70, www.gdch.de/taetigkeiter/bua/berichte.htm (last accessed December 04).
    • (2000) BUA GDCh Advisory Committee on Existing Chemicals , Issue.70
  • 4
    • 0037350372 scopus 로고    scopus 로고
    • Recommended tissue list for histopathologic examination in repeat-dose toxicity and carcinogenicity studies: a proposal of the Society of Toxicologic Pathology (STP)
    • Bregman, C. L., Adler, R. R., Morton, D. G. et al. 2003: Recommended tissue list for histopathologic examination in repeat-dose toxicity and carcinogenicity studies: a proposal of the Society of Toxicologic Pathology (STP). Toxicologic Pathology 31, 252-253.
    • (2003) Toxicologic Pathology , vol.31 , pp. 252-253
    • Bregman, C.L.1    Adler, R.R.2    Morton, D.G.3
  • 5
    • 18744406466 scopus 로고    scopus 로고
    • Reproductive and Cancer Hazard Assessment Section. Office of Environmental Health Hazard Assess-ment(OEHHA). Retrievedfrom: (last accessed December 04)
    • California Environmental Protection Agency (Cal-EPA). 2002: No significant risk level for the Proposition 65 carcinogen benzofuran. Reproductive and Cancer Hazard Assessment Section. Office of Environmental Health Hazard Assess-ment(OEHHA).Retrievedfrom:http://www.oehha.ca.gov/prop65/CRNR_notices/pdf_zip/BenzofuranNSRL%20_Aug%202002.pdf (last accessed December 04).
    • (2002) No significant risk level for the Proposition 65 carcinogen benzofuran
  • 6
    • 18744379025 scopus 로고
    • EPA Doc. No. 40-8972396. Fiche No.OTS0525082. Summarized in TSCATS on-line record for 2-mercaptobenzothiazole. Retrieved from: (last accessed December 04)
    • Chemical Manufacturers Association (CMA). 1989: Letter from Chemical Manufacturers Association to US EPA regarding information on the enclosed final reports on 2-mercaptobenzothiazole. EPA Doc. No. 40-8972396. Fiche No.OTS0525082. Summarized in TSCATS on-line record for 2-mercaptobenzothiazole. Retrieved from: http://esc.syrres.com/efdb/TSCATS.htm (last accessed December 04).
    • (1989) Letter from Chemical Manufacturers Association to US EPA regarding information on the enclosed final reports on 2-mercaptobenzothiazole
  • 8
    • 0032816474 scopus 로고    scopus 로고
    • Contact allergy to mercaptobenzothiazole in a bank clerk from a wet sponge
    • Corazza, M., Maranini, C., Venturini, D. and Virgili, A. 1999: Contact allergy to mercaptobenzothiazole in a bank clerk from a wet sponge. Contact Dermatitis 41, 105-106.
    • (1999) Contact Dermatitis , vol.41 , pp. 105-106
    • Corazza, M.1    Maranini, C.2    Venturini, D.3    Virgili, A.4
  • 9
    • 0021864517 scopus 로고
    • Mutagenicity studies in a tyre plant: in vitro activity of workers’ urinary concentrates and raw materials
    • Crebelli, R., Paoletti, A., Falcone, E. et al. 1985: Mutagenicity studies in a tyre plant: in vitro activity of workers’ urinary concentrates and raw materials. British Journal of Industrial Medicine 42, 481-487.
    • (1985) British Journal of Industrial Medicine , vol.42 , pp. 481-487
    • Crebelli, R.1    Paoletti, A.2    Falcone, E.3
  • 11
    • 0024356756 scopus 로고
    • Disposition of 2-mercaptobenzothiazole and 2-mercapto-benzothiazole disulfide in rats dosed intravenously, orally, and topically and in guinea pigs dosed topically
    • El Dareer, S. M., Kalin, J. R., Tillery, K. F. et al. 1989: Disposition of 2-mercaptobenzothiazole and 2-mercapto-benzothiazole disulfide in rats dosed intravenously, orally, and topically and in guinea pigs dosed topically. Journal of Toxicology and Environmental Health 27, 65-84.
    • (1989) Journal of Toxicology and Environmental Health , vol.27 , pp. 65-84
    • El Dareer, S.M.1    Kalin, J.R.2    Tillery, K.F.3
  • 12
    • 0032608960 scopus 로고    scopus 로고
    • Long- and medium-term carcinogenicity studies in animals and short-term genotoxicity tests
    • In Moolgavkar, S., Krewski, D., Zeise, L., Cardis, E. and Moller, H., editors Lyon: IARC Press
    • Feron, V. J., Schwarz, M., Hemminki, K. and Krewski, D. 1999: Long- and medium-term carcinogenicity studies in animals and short-term genotoxicity tests. In Moolgavkar, S., Krewski, D., Zeise, L., Cardis, E. and Moller, H., editors, Quantitative estimation and predication of human cancer risks. Lyon: IARC Press, 103-129.
    • (1999) Quantitative estimation and predication of human cancer risks , pp. 103-129
    • Feron, V.J.1    Schwarz, M.2    Hemminki, K.3    Krewski, D.4
  • 13
    • 0023608617 scopus 로고
    • The metabolic origin of the sulfur atom in the sulfhydryl group of 2-thioben-zothiazole
    • Fukuoka, M. and Tanaka, A. 1987: The metabolic origin of the sulfur atom in the sulfhydryl group of 2-thioben-zothiazole. Archives of Toxicology 61, 158-160.
    • (1987) Archives of Toxicology , vol.61 , pp. 158-160
    • Fukuoka, M.1    Tanaka, A.2
  • 14
    • 84998015203 scopus 로고
    • Mutagenicity evaluation of Captax
    • 2000.
    • Goodyear. 1980: Mutagenicity evaluation of Captax. Summarized in BUA, 2000.
    • (1980) Summarized in BUA
  • 15
    • 0002454677 scopus 로고
    • Adrenal gland
    • In Boornman, G. A., Eustis, S. L., Elwell, M. R., Montgomery, C. A. and Mackenzie, W. F., editors New York, NY: Academic Press
    • Hamlin, M. H. and Banas, D. A. 1990: Adrenal gland. In Boornman, G. A., Eustis, S. L., Elwell, M. R., Montgomery, C. A. and Mackenzie, W. F., editors, Pathology of the Fischer rat: reference and atlas, New York, NY: Academic Press, 501-517.
    • (1990) Pathology of the Fischer rat: reference and atlas , pp. 501-517
    • Hamlin, M.H.1    Banas, D.A.2
  • 17
    • 0031955224 scopus 로고    scopus 로고
    • Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: a National Toxicology Program update
    • Haseman, J. K., Hailey, J. R. and Morris, R. W. 1998: Spontaneous neoplasm incidences in Fischer 344 rats and B6C3F1 mice in two-year carcinogenicity studies: a National Toxicology Program update. Toxicologic Pathology 26, 428-441.
    • (1998) Toxicologic Pathology , vol.26 , pp. 428-441
    • Haseman, J.K.1    Hailey, J.R.2    Morris, R.W.3
  • 18
    • 18744403566 scopus 로고    scopus 로고
    • (last accessed December 04)
    • Hazardous Substance Databank (HSDB). 2004: 2-Mercapto-benzothiazole on-line record http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?HSDB (last accessed December 04).
    • (2004) 2-Mercapto-benzothiazole on-line record
  • 20
    • 0014527579 scopus 로고
    • Bioassay of pesticides and industrial chemicals for tumor-igenicity in mice: a preliminary note
    • Innes, J. R. M., Ulland, B. M., Valerio, M. G. et al. 1969: Bioassay of pesticides and industrial chemicals for tumor-igenicity in mice: a preliminary note. Journal of the National Cancer Institute 42, 1101-1114.
    • (1969) Journal of the National Cancer Institute , vol.42 , pp. 1101-1114
    • Innes, J.R.M.1    Ulland, B.M.2    Valerio, M.G.3
  • 21
    • 0009606829 scopus 로고
    • Urinary bladder, ureter, and urethra
    • In Boornman, G. A., Eustis, S. L., Elwell, M. R., Montgomery, C. A. and Mackenzie, W. F., editors New York, NY: Academic Press
    • Jokinen, M. P. 1990: Urinary bladder, ureter, and urethra. In Boornman, G. A., Eustis, S. L., Elwell, M. R., Montgomery, C. A. and Mackenzie, W. F., editors. Pathology of the Fischer rat: reference and atlas. New York, NY: Academic Press, 109-126.
    • (1990) Pathology of the Fischer rat: reference and atlas , pp. 109-126
    • Jokinen, M.P.1
  • 22
    • 0032603423 scopus 로고    scopus 로고
    • Human bladder cancer: epidemiological, pathological, and mechanistic aspects
    • Retrieved from: (last accessed December 04)
    • La Vecchia, C. and Airoldi, L. 1999: Human bladder cancer: epidemiological, pathological, and mechanistic aspects. IARC Scientific Publications 147, 139-157. Retrieved from: http://monographs.iarc.fr/htdocs/iarcpubs/pub147/pub147consensus.html (last accessed December 04).
    • (1999) IARC Scientific Publications , vol.147 , pp. 139-157
    • La Vecchia, C.1    Airoldi, L.2
  • 23
    • 84997858689 scopus 로고
    • Summarized in NTP, 1988. Study ID 920542. Accessed through the NTP on-line study database
    • Litton. 1985: Report to the Chemical Manufacturer's Association. Summarized in NTP, 1988. Study ID 920542. Accessed through the NTP on-line study database: http://ntp-server.niehs.nih.gov/Main_Pages/SearchData.html
    • (1985) Report to the Chemical Manufacturer's Association
  • 25
    • 0025104281 scopus 로고
    • L5178 mouse lymphoma cell mutation assays results with 41 compounds
    • Myhr, B., McGregor, D., Bowers, L. et al. 1990: L5178 mouse lymphoma cell mutation assays results with 41 compounds. Environmental and Molecular Mutagenesis 16, 138-167.
    • (1990) Environmental and Molecular Mutagenesis , vol.16 , pp. 138-167
    • Myhr, B.1    McGregor, D.2    Bowers, L.3
  • 27
    • 18744391263 scopus 로고
    • Study ID A62048. Accessed through the NTP on-line study database: (last accessed December 04)
    • National Toxicology Program (NTP). 1993: Micronucleus test of 2-mercaptobenzothiazole. Study ID A62048. Accessed through the NTP on-line study database: http://ntp-apps.niehs.nih.gov/ntp_tox/index.cfm (last accessed December 04).
    • (1993) Micronucleus test of 2-mercaptobenzothiazole
  • 28
    • 18744381447 scopus 로고    scopus 로고
    • Retrieved from: (last accessed December 04)
    • National Toxicology Program (NTP). 1999: NTP historical control information for the NIH-07 diet. Retrieved from: http://ehp.niehs.nih.gov/ntp/docs/ntp_hcrs.html (last accessed December 04).
    • (1999) NTP historical control information for the NIH-07 diet
  • 29
    • 0003827216 scopus 로고
    • Cited in the HSDB online record for 2-mercaptoben-zothiazole.
    • National Institute of Occupational Safety and Health (NIOSH). 1989: National Occupational Exposure Survey. Cited in the HSDB online record for 2-mercaptoben-zothiazole.
    • (1989) National Occupational Exposure Survey
  • 30
    • 18744375612 scopus 로고    scopus 로고
    • Available for purchase at (last accessed January 05)
    • National Sanitation Foundation (NSF). 2003: Standard 61: Drinking Water System Components-Health Effects. Available for purchase at www.nsf.org (last accessed January 05).
    • (2003) Standard 61: Drinking Water System Components-Health Effects
  • 31
    • 0024947994 scopus 로고
    • Toxicity of 2-mercaptobenzothiazole in mice
    • summarized in ACC, 2001. Retrieved from: (last accessed December 04)
    • Ogawa, Y., Kamata, E., Suzuki, S. et al. 1989: Toxicity of 2-mercaptobenzothiazole in mice. Bull Natl Inst Hyg Sci 107, 44-50, summarized in ACC, 2001. Retrieved from: http://www.epa.gov/chemrtk/bnzthict/c13324rs.pdf (last accessed December 04).
    • (1989) Bull Natl Inst Hyg Sci , vol.107 , pp. 44-50
    • Ogawa, Y.1    Kamata, E.2    Suzuki, S.3
  • 32
    • 0015963487 scopus 로고
    • Guidelines on the analysis of tumor rates and death rates in experimental animals
    • Peto, R. 1974: Guidelines on the analysis of tumor rates and death rates in experimental animals. British Journal of Cancer 29, 101-105.
    • (1974) British Journal of Cancer , vol.29 , pp. 101-105
    • Peto, R.1
  • 33
    • 0019291735 scopus 로고
    • Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments
    • Suppl. 2. IARC Press
    • Peto, R., Pike, M. C., Day, N. E. et al. 1980: Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments. In IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, Suppl. 2. IARC Press, 311-346.
    • (1980) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans , pp. 311-346
    • Peto, R.1    Pike, M.C.2    Day, N.E.3
  • 34
    • 0021647476 scopus 로고
    • The TD50: a proposed general convention for the numerical description of the carcinogenic potency of chemicals in chronic-exposure animal experiments
    • Retrieved from: (last accessed December 04)
    • Peto, R., Pike, M. C., Berstein, L. et al. 1984: The TD50: a proposed general convention for the numerical description of the carcinogenic potency of chemicals in chronic-exposure animal experiments. Environmental Health Perspectives 58, 1-8. Retrieved from: http://potency.berkeley.edu/pdfs/Peto1984.pdf (last accessed December 04).
    • (1984) Environmental Health Perspectives , vol.58 , pp. 1-8
    • Peto, R.1    Pike, M.C.2    Berstein, L.3
  • 36
    • 84998183897 scopus 로고
    • Urinary tract
    • Volume II, ninth edition. Philadelphia, PA: Lea and Febiger.
    • Ritchie, A. C. 1990: Urinary tract. In Boyd's textbook of pathology, Volume II, ninth edition. Philadelphia, PA: Lea and Febiger.
    • (1990) Boyd's textbook of pathology
    • Ritchie, A.C.1
  • 38
    • 0027438449 scopus 로고
    • Mortality study of workers employed at a plant manufacturing chemicals for the rubber industry: 1955-1986
    • Sorahan, T. and Pope, D. 1993: Mortality study of workers employed at a plant manufacturing chemicals for the rubber industry: 1955-1986. British Journal of Industrial Medicine 50, 998-1002.
    • (1993) British Journal of Industrial Medicine , vol.50 , pp. 998-1002
    • Sorahan, T.1    Pope, D.2
  • 39
    • 0033627357 scopus 로고    scopus 로고
    • A further cohort study of workers employed at a factory manufacturing chemicals for the rubber industry, with special emphasis to the chemicals 2-mercaptobenzothia-zole (MBT), aniline, phenyl-b-naphthylamine and o-tolui-dine
    • Sorahan, T., Hamilton, L. and Jackson, J. R. 2000: A further cohort study of workers employed at a factory manufacturing chemicals for the rubber industry, with special emphasis to the chemicals 2-mercaptobenzothia-zole (MBT), aniline, phenyl-b-naphthylamine and o-tolui-dine. Occupational and Environmental Medicine 57, 106-115.
    • (2000) Occupational and Environmental Medicine , vol.57 , pp. 106-115
    • Sorahan, T.1    Hamilton, L.2    Jackson, J.R.3
  • 41
    • 0002936923 scopus 로고
    • Spleen, lymph nodes and thymus
    • In Boorman, G. A., Eustis, S. L., Elwell, M. R., Montgomery, C. A. and Mackenzie, W. F., editors New York, NY: Academic Press
    • Stefanski, S. A. 1990: Spleen, lymph nodes and thymus. In Boorman, G. A., Eustis, S. L., Elwell, M. R., Montgomery, C. A. and Mackenzie, W. F., editors, Pathology of the Fischer rat: reference and atlas. New York, NY: Academic Press, 369-393.
    • (1990) Pathology of the Fischer rat: reference and atlas , pp. 369-393
    • Stefanski, S.A.1
  • 42
    • 0027482699 scopus 로고
    • Mortality experience of employees exposed to 2-mercap-tobenzothiazole at a chemical plant in Nitro, West Virginia
    • Strauss, M. E., Barrick, E. D. and Bannister, R. M. 1993: Mortality experience of employees exposed to 2-mercap-tobenzothiazole at a chemical plant in Nitro, West Virginia. British Journal of Industrial Medicine 50, 888-893.
    • (1993) British Journal of Industrial Medicine , vol.50 , pp. 888-893
    • Strauss, M.E.1    Barrick, E.D.2    Bannister, R.M.3
  • 43
    • 18744381717 scopus 로고    scopus 로고
    • (last accessed December 04)
    • Toxic Substances Control Act Database (TSCATS). 2003: 2-Mercaptobenzothiazole. http://esc.syrres.com/efdb/TSCATS.htm (last accessed December 04).
    • (2003) 2-Mercaptobenzothiazole
  • 45
    • 0003662518 scopus 로고    scopus 로고
    • Washington, DC: Risk Assessment Forum. NCEAF-0644. Retrieved from (last accessed December 04)
    • US Environmental Protection Agency (US EPA). 1999a: Draft revised guidelines for carcinogen risk assessment. Washington, DC: Risk Assessment Forum. NCEAF-0644. Retrieved from: http://cfpub2.epa.gov/ncea/raf/cancer.cfm (last accessed December 04).
    • (1999) Draft revised guidelines for carcinogen risk assessment
  • 47
    • 0141592161 scopus 로고    scopus 로고
    • EPA/630/R-00/001. Retrieved from: (last accessed December 04)
    • US Environmental Protection Agency (US EPA). 2000a: Benchmark dose technical guidance manual. EPA/630/R-00/001. Retrieved from: http://www.epa.gov/ncea/pdfs/bmds/BMD-External_10_13_2000.pdf (last accessed December 04).
    • (2000) Benchmark dose technical guidance manual
  • 49
    • 0142098904 scopus 로고    scopus 로고
    • Retrieved from: (last accessed December 04)
    • US Environmental Protection Agency (US EPA). 2003a: Draft final guidelines for cancer risk assessment. Retrieved from: http://cfpub.epa.gov/ncea/raf/recordisplay.cfm?deid/55868 (last accessed December 04).
    • (2003) Draft final guidelines for cancer risk assessment
  • 50
    • 18744384846 scopus 로고    scopus 로고
    • Version 1.3.2. Retrieved from: (last accessed December 04)
    • US Environmental Protection Agency (US EPA). 2003b: Benchmark dose software. Version 1.3.2. Retrieved from: http://cfpub2.epa.gov/ncea/cfm/recordisplay.cfm?deid-20167 (last accessed December 04).
    • (2003) Benchmark dose software
  • 51
    • 84998029409 scopus 로고    scopus 로고
    • Office of Research and Development. Retrieved from: (last accessed December 04)
    • US Environmental Protection Agency (US EPA). 2004: Toxicological review for 1,2-dibromoethane. Integrated Risk Information System (IRIS). Office of Research and Development. Retrieved from: http://www.epa.gov/iris/toxreviews/0361-tr.pdf (last accessed December 04).
    • (2004) Toxicological review for 1,2-dibromoethane. Integrated Risk Information System (IRIS)
  • 52
    • 0344609341 scopus 로고
    • Gadsden, AL: Goodyear Tire and Rubber Company. Hazard Evaluations and Technical Assistance Branch, NIOSH, US Department of Health and Human Services, Cincinnati, OH, Report No. HETA-83-196-1492.
    • Williams, T.M., Hickey, J.L.S. and Bishop, C.C. 1984: Health hazard evaluation report No. HETA-83-196-1492. Gadsden, AL: Goodyear Tire and Rubber Company. Hazard Evaluations and Technical Assistance Branch, NIOSH, US Department of Health and Human Services, Cincinnati, OH, Report No. HETA-83-196-1492.
    • (1984) Health hazard evaluation report No. HETA-83-196-1492
    • Williams, T.M.1    Hickey, J.L.S.2    Bishop, C.C.3


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