Effect of exercise on transdermal nicotine release in healthy habitual smokers

International Journal of Clinical Pharmacology and Therapeutics

Volumn 43, Issue 5, 2005, Pages 239-243

  Bur, A ^a   Joukhadar, C ^a   Klein, N ^a   Herkner, H ^a   Mitulovic, G ^a   Schmid, R ^a   Agneter, E ^a   Muller M ^a   Brunner, Martin ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Microdialysis; Pharmacokinetics; Physical activity; Plasma concentration; Tissue concentration

Indexed keywords

NICOTINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG RELEASE; DRUG TISSUE LEVEL; EXERCISE; HUMAN; MALE; MICRODIALYSIS; PHYSICAL ACTIVITY; RANDOMIZED CONTROLLED TRIAL; REST; SIDE EFFECT; SKIN BLOOD FLOW; SMOKING CESSATION; TRANSDERMAL PATCH;

EID: 18744395190     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP43239     Document Type: Article

References (19)

1. Berner B, John VA 1994 Pharmacokinetic characterization of transdermal delivery systems. Clin Pharmacokinet 26: 121-134
2. Fiore MC, Smith SS, Jorenby DE, Baker TB 1991 The effectiveness of the nicotine patch for smoking cessation. A meta-analysis. JAMA 271: 1940-1947
3. Gupta SK, Okerholm RA, Eller M, Wie G, Rolf CN, Gorsline J 1995 Comparison of the pharmacokinetics of two nicotine transdermal systems: nicoderm and habitrol. J Clin Pharmacol 35: 493-498
4. Health Canada 1996 Canadian Adverse Drug Reaction Newsletter 6, January 1996. Can Med Assoc J 154: 61-63
5. Homsy W, Yan K, Houle JM. Besner JG, Gossard D, Pierce C, Caille'G 1997 Plasma levels of nicotine and safety of smokers wearing transdermal delivery systems during multiple simultaneous intake of nicotine and during exercise. J Clin Pharmacol 37: 728-736
6. Hori M, Ohtsuka S, Sunami M, Guy RH, Maibach HI 1990 Cutaneous pharmacodynamics of transdermally delivered isosorbide dinitrate. Pharm Res 7: 1298-1301
7. Khazaeinia T, Ramsey A, Tam Y 2000 The effects of exercise on the pharmacokinetics of drugs. J Pharm Sci 3: 292-302
8. Kimmel SE, Berlin JA, Miles C, Jaskowiak J, Carson JL, Strom BL 2001 Risk of acute first myocardial infarction and use of nicotine patches in a general population. J Am Coll Cardiol 37: 1297-1302
9. Klemsdal TO, Gjesdal K, Bredesen JE 1992 Heating and cooling of the nitroglycerin patch application area modify the plasma level of nitroglycerin. Eur J Clin Pharmacol 43: 625-628
10. Klemsdal TO, Gjesdal K, Zahlsen K 1995 Physical exercise increases plasma concentrations of nicotine during treatment with a nicotine patch. Br J Clin Pharmacol 39: 677-679
11. Kochak GM, Sun JX, Choi RL, Piraino AJ 1992 Pharmacokinetic disposition of multiple-dose transdermal nicotine in healthy adult smokers. Pharm Res 9: 1451-1455
12. Mitulovic G 2001 Specific determination of clinical and toxicological important substances in biological samples by LC-MS. Doctoral Dissertation University of Vienna, Department of Laboratory Medicine, Vienna, Austria, February 2001
13. Müller M 2000 Microdialysis in clinical drug delivery studies. Adv Drug Deliv Rev 45: 255-269
14. Müller M, Schmid R, Wagner O, von Osten B, Shayganfar H, Eichler HG 1995 In vivo characterization of transdermal drug transport by microdialysis. J Contr Release 37: 49-57
15. Palmer KJ, Buckley MM, Faulds D 1992 Transdermal nicotine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy as an aid to smoking cessation. Drugs 44: 498-529
16. Shah VP, Flynn GL, Yacobi A, Maibach HI, Bon C, Fleischer NM, Franz TJ, Kaplan SA, Kawamoto J, Lesko LJ, Marty JP, Pershing LK, Schaefer H, Sequeira SP, Shrivastava SP, Wilkin J, Williams RL 1998 Bioequivalence of topical dermatological dosage forms - methods of evaluation of bioequivalence. Pharm Res 15: 167-171
17. Silagy C, Mant D, Fowler G, Lodge M 1994 Meta-analysis on efficacy of nicotine replacement therapies in smoking cessation. Lancet 343: 139-142
18. Transdermal Nicotine Study Group 1991 Transdermal nicotine for smoking cessation: six-month results from two multicenter controlled clinical trials. JAMA 266: 3128-3133
19. Ylitalo P 1991 Effect of exercise on pharmacokinetics. Ann Med 23: 289-294