Cutaneous allergic reaction to heparins: Subcutaneous but not intravenous provocation

Contact Dermatitis

Volumn 52, Issue 4, 2005, Pages 228-230

  Maroto Iitani, Maria ^a   Higaki, Yuko ^a   Kawashima, Makoto ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Calcium heparin; Cutaneous adverse drug reactions; Delayed type hypersensitivity; Heparin; Late phase reaction

Indexed keywords

CAPREOMYCIN; HEPARIN; HEPARIN CALCIUM; IMMUNOGLOBULIN E; LOW MOLECULAR WEIGHT HEPARIN; NOVO HEPARIN;

ADULT; ARTICLE; CASE REPORT; DELAYED HYPERSENSITIVITY; DRUG SUBSTITUTION; DRUG TOLERABILITY; ERYTHEMA; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOPATHOLOGY; INJECTION SITE; INTRACUTANEOUS TEST; LYMPHOCYTIC INFILTRATION; PATCH TEST; PATHOPHYSIOLOGY; PRICK TEST; PROVOCATION TEST; PRURITUS; SKIN ALLERGY; SKIN COLOR; SKIN INDURATION; SKIN MANIFESTATION; TIME SERIES ANALYSIS;

ADULT; DERMATITIS, ALLERGIC CONTACT; FEMALE; FIBRINOLYTIC AGENTS; HEPARIN; HUMANS; INJECTIONS, SUBCUTANEOUS;

EID: 18744389467     PISSN: 01051873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0105-1873.2005.0566d.x     Document Type: Article

References (11)

1. Korstanje M J, Bessems P J M J, Hardy E, van de Staak W J B M. Delayed-type hypersensitivity reaction to heparin. Contact Dermatitis 1989: 20: 383-384.
2. Bircher A J, Flueckiger R, Buchner S A. Eczematous infiltrated plaques to subcutaneous heparin: a type IV allergic reaction. Br J Dermatol 1990: 123: 507-514.
3. Boehncke W H, Weber L, Gall H. Tolerance to intravenous administration of heparin and heparinoid in a patient with delayed-type hypersensitivity to heparins and heparinoids. Contact Dermatitis 1996: 35: 73-75.
4. Klein G F, Kofler H, Wolf H, Frisch P O. Eczema-like, erythematous, infiltrated plaques: a common side effect of subcutaneous heparin therapy. J Am Acad Dermatol 1989: 21: 703-707.
5. Guillet G, Delaire P, Plantin P, Guillet M H. Eczema as a complication of heparin therapy. J Am Acad Dermatol 1989: 20: 1130-1132.
6. Moreau A, Dompmartin A, Esnault P, Michel M, Leroy D. Delayed hypersensitivity at the injection site of a low-molecular-weight heparin. Contact Dermatitis 1996: 34: 31-34.
7. Young E. Allergy to subcutaneous heparin. Contact Dermatitis 1988: 19: 152-153.
8. Hallai N, Hughes T M, Stone N. Type I and type IV allergy to unfractionated heparin and low-molecular-weight heparin with no reaction to recombinant hirudin. Contact Dermatitis 2004: 51: 153-154.
9. Grassegger A, Fritsch P, Reider N. Delayed-type hypersensitivity and cross-reactivity to heparins and danaparoid: a prospective study. Dermatologic Surg 2001: 27: 47-52.
10. Koch P. Delayed-type hypersensitivity skin reactions due to heparins and heparinoids. Tolerance of recombinant hirudins and of the new synthetic anticoagulant fondaparinux. Contact Dermatitis 2004: 49: 276-280.
11. Ulrick P J, Manoharan A. Heparin-induced skin reaction. Med J Aust 1984: 140: 287-289.