메뉴 건너뛰기




Volumn 25, Issue 1, 1995, Pages

Clinical evaluation of oral administration of a cholecystokinin-a receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: A multicenter dose-response study in japan

Author keywords

CCK receptor antagonist; Chronic pancreatitis; Loxiglumide

Indexed keywords

AMYLASE; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ RECEPTOR; DRUG DERIVATIVE; HORMONE ANTAGONIST; LOXIGLUMIDE; PROGLUMIDE; TRIACYLGLYCEROL LIPASE; TRYPSIN;

EID: 18744389156     PISSN: 03604039     EISSN: 15388689     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (43)

References (37)
  • 1
    • 0021907247 scopus 로고
    • Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin
    • Niederau C, Ferrell LD, Grendell JH. Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin. Gastroenterology 1985; 88:1192-204.
    • (1985) Gastroenterology , vol.88 , pp. 1192-1204
    • Niederau, C.1    Ferrell, L.D.2    Grendell, J.H.3
  • 2
    • 0001563463 scopus 로고
    • Supramaximal caerulein stimulation and ultrastructure of rat pancreas acinar cells: Early morphological changes during development of experimental pancreatitis
    • Watanabe O, Baccino FM, Steer ML, et al. Supramaximal caerulein stimulation and ultrastructure of rat pancreas acinar cells: early morphological changes during development of experimental pancreatitis. Am J Physiol 1984; 246:G457-67.
    • (1984) Am J Physiol , vol.246
    • Watanabe, O.1    Baccino, F.M.2    Steer, M.L.3
  • 3
    • 0022318458 scopus 로고
    • In vivo rat acinar cell function during submaximal stimulation with caerulein
    • Saluja A, Saito I, Saluja M, et al. In vivo rat acinar cell function during submaximal stimulation with caerulein. Am J Physiol 1985; 249:G702-10.
    • (1985) Am J Physiol , vol.249
    • Saluja, A.1    Saito, I.2    Saluja, M.3
  • 4
    • 0022826388 scopus 로고
    • Time course and cellular source of pancreatic regeneration following acute pancreatitis in the rat
    • Elsasser HP, Adler G, Kern HF. Time course and cellular source of pancreatic regeneration following acute pancreatitis in the rat. Pancreas 1986; 1:421-9.
    • (1986) Pancreas , vol.1 , pp. 421-429
    • Elsasser, H.P.1    Adler, G.2    Kern, H.F.3
  • 5
    • 0023025329 scopus 로고
    • Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice: evidence for cholecystokinin as major factor in the development of acute pancreatitis
    • Niederau C, Liddle RA, Ferrell LD, et al. Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice: evidence for cholecystokinin as major factor in the development of acute pancreatitis. J Clin Invest 1986; 78:1056-63.
    • (1986) J Clin Invest , vol.78 , pp. 1056-1063
    • Niederau, C.1    Liddle, R.A.2    Ferrell, L.D.3
  • 6
    • 0022861085 scopus 로고
    • Protective effect of CR 1409 (Cholecystokinin antagonist) on experimental pancreatitis in rats and mice
    • Makovec F, Bani M, Cereda R, et al. Protective effect of CR 1409 (cholecystokinin antagonist) on experimental pancreatitis in rats and mice. Peptides 1986; 7:1159-64.
    • (1986) Peptides , vol.7 , pp. 1159-1164
    • Makovec, F.1    Bani, M.2    Cereda, R.3
  • 7
    • 0023708169 scopus 로고
    • Asperlicin, a nonpeptideal cholecystokinin receptor antagonist, attenuates sodium taurocholate-induced acute pancreatitis in rats
    • Wisner, JR., Renner IG. Asperlicin, a nonpeptideal cholecystokinin receptor antagonist, attenuates sodium taurocholate-induced acute pancreatitis in rats. Pancreas 1988; 3:174-9.
    • (1988) Pancreas , vol.3 , pp. 174-179
    • Wisner, J.R.1    Renner, I.G.2
  • 8
    • 0028269790 scopus 로고
    • Therapeutic and protective effect of subcutaneous injections of L-364,718 on caerulein-induced acute pancreatitis
    • Garcia-Montero AC, Manso MA, Rodriguez AI, et al. Therapeutic and protective effect of subcutaneous injections of L-364,718 on caerulein-induced acute pancreatitis. Pancreas 1994; 9:309-15.
    • (1994) Pancreas , vol.9 , pp. 309-315
    • Garcia-Montero, A.C.1    Manso, M.A.2    Rodriguez, A.I.3
  • 9
    • 0033056955 scopus 로고    scopus 로고
    • Therapeutic effects of loxiglumide on experimental acute pancreatitis using various models
    • Satake K, Kimura K, Saito T. Therapeutic effects of loxiglumide on experimental acute pancreatitis using various models. Digestion 1999; 60(suppl 1):64-8.
    • (1999) Digestion , vol.60 , pp. 64-68
    • Satake, K.1    Kimura, K.2    Saito, T.3
  • 10
    • 0033055734 scopus 로고    scopus 로고
    • Clinical evaluation of cholecystokinin-A-receptor antagonist (Loxiglumide) for the treatment of acute pancreatitis: A preliminary clinical trial
    • Ochi K, Harada H, Satake K, et al. Clinical evaluation of cholecystokinin-A-receptor antagonist (loxiglumide) for the treatment of acute pancreatitis: a preliminary clinical trial. Digestion 1999; 60(suppl 1):81-5.
    • (1999) Digestion , vol.60 , pp. 81-85
    • Ochi, K.1    Harada, H.2    Satake, K.3
  • 11
    • 61849087137 scopus 로고    scopus 로고
    • Clinical evaluation of CCK-A receptor antagonist (Loxiglumide) on acute symptoms during acute pancreatitis: Multicenter double blind studies with nafamostat mesylate
    • Satake K, Matsuno S, Shiratori K, et al. Clinical evaluation of CCK-A receptor antagonist (loxiglumide) on acute symptoms during acute pancreatitis: multicenter double blind studies with nafamostat mesylate. Pancreas 1999; 19:436.
    • (1999) Pancreas , vol.19 , pp. 436
    • Satake, K.1    Matsuno, S.2    Shiratori, K.3
  • 13
    • 0032939170 scopus 로고    scopus 로고
    • The natural history of pain in alcoholic chronic pancreatitis
    • Ammann RW, Muelhaupt B. The natural history of pain in alcoholic chronic pancreatitis. Gastroenterology 1999; 116:1132-40.
    • (1999) Gastroenterology , vol.116 , pp. 1132-1140
    • Ammann, R.W.1    Muelhaupt, B.2
  • 14
    • 0021875468 scopus 로고
    • Plasma cholecystokinin levels in patients with chronic pancreatitis
    • Schafmeyer A, Becker HP, Werner M, et al. Plasma cholecystokinin levels in patients with chronic pancreatitis. Digestion 1985; 32:136-9.
    • (1985) Digestion , vol.32 , pp. 136-139
    • Schafmeyer, A.1    Becker, H.P.2    Werner, M.3
  • 15
    • 0025895101 scopus 로고
    • Basal and postprandial cholecystokinin values in chronic pancreatitis with and without abdominal pain
    • Gomez-Cerezo J, Codoceo R, Fernandez-Calle P, et al. Basal and postprandial cholecystokinin values in chronic pancreatitis with and without abdominal pain. Digestion 1991; 48:134-40.
    • (1991) Digestion , vol.48 , pp. 134-140
    • Gomez-Cerezo, J.1    Codoceo, R.2    Fernandez-Calle, P.3
  • 16
    • 0344589350 scopus 로고    scopus 로고
    • Relationship of basal and postprandial intraduodenal bile acid concentrations and plasma cholecystokinin levels with abdominal pain in patients with chronic pancreatitis
    • Garces MC, Gomez-Cerezo J, Alba D, et al. Relationship of basal and postprandial intraduodenal bile acid concentrations and plasma cholecystokinin levels with abdominal pain in patients with chronic pancreatitis. Pancreas 1998; 17:397-401.
    • (1998) Pancreas , vol.17 , pp. 397-401
    • Garces, M.C.1    Gomez-Cerezo, J.2    Alba, D.3
  • 17
    • 0022479652 scopus 로고
    • Feedback regulation of pancreatic enzyme secretion: Suppression of cholecystokinin release by trypsin
    • Owyang C, Louie DS, Tatum D. Feedback regulation of pancreatic enzyme secretion: suppression of cholecystokinin release by trypsin. J Clin Invest 1986; 77:2042-7.
    • (1986) J Clin Invest , vol.77 , pp. 2042-2047
    • Owyang, C.1    Louie, D.S.2    Tatum, D.3
  • 18
    • 0025326051 scopus 로고
    • Feedback regulation of human pancreatic secretion: Effective protease inhibition of duodenal, liver, and small intestinal transit of pancreatic enzymes
    • Layer P, Janson JBMJ, Cherian L, et al. Feedback regulation of human pancreatic secretion: effective protease inhibition of duodenal, liver, and small intestinal transit of pancreatic enzymes. Gastroenterology 1990; 98:1311-9.
    • (1990) Gastroenterology , vol.98 , pp. 1311-1319
    • Layer, P.1    Janson, J.2    Cherian, L.3
  • 19
    • 0027973159 scopus 로고
    • Roles of gut hormones in negative-feedback regulation of pancreatic exocrine secretion in humans
    • Jin HO, Song CW, Chang TM, et al. Roles of gut hormones in negative-feedback regulation of pancreatic exocrine secretion in humans. Gastroenterology 1994; 107:1828-34.
    • (1994) Gastroenterology , vol.107 , pp. 1828-1834
    • Jin, H.O.1    Song, C.W.2    Chang, T.M.3
  • 20
    • 0022347513 scopus 로고
    • Low plasma cholecystokinin response after ingestion of a test meal in patients with chronic pancreatitis
    • Funakoshi A, Nakano I, Shinozaki H, et al. Low plasma cholecystokinin response after ingestion of a test meal in patients with chronic pancreatitis. Am J Gastroenterol 1985; 80:937-40.
    • (1985) Am J Gastroenterol , vol.80 , pp. 937-940
    • Funakoshi, A.1    Nakano, I.2    Shinozaki, H.3
  • 21
    • 0023903245 scopus 로고
    • Plasma CCK levels in patients with pancreatic insufficiency
    • Bozkurt T, Adler G, Koop I, et al. Plasma CCK levels in patients with pancreatic insufficiency. Dig Dis Sci 1988; 33:276-81.
    • (1988) Dig Dis Sci , vol.33 , pp. 276-281
    • Bozkurt, T.1    Adler, G.2    Koop, I.3
  • 22
    • 0025375662 scopus 로고
    • Effect of a cholecystokinin antagonist, loxiglumide, on pancreatic secretion in patients with chronic pancreatitis
    • Adler G, Reinshagen M, Beglinger C, et al. Effect of a cholecystokinin antagonist, loxiglumide, on pancreatic secretion in patients with chronic pancreatitis. Biomed Res 1990; 11:151-6.
    • (1990) Biomed Res , vol.11 , pp. 151-156
    • Adler, G.1    Reinshagen, M.2    Beglinger, C.3
  • 23
    • 0025753886 scopus 로고
    • Plasma concentrations of neurotensin and CCK in patients with chronic pancreatitis with and without enzyme substitution
    • Nustede R, Kohler H, Folsch UR, et al. Plasma concentrations of neurotensin and CCK in patients with chronic pancreatitis with and without enzyme substitution. Pancreas 1991; 6:260-5.
    • (1991) Pancreas , vol.6 , pp. 260-265
    • Nustede, R.1    Kohler, H.2    Folsch, U.R.3
  • 24
    • 0030938318 scopus 로고    scopus 로고
    • Altered postprandial motility in chronic pancreatitis: Role of malabsorption
    • Layer P, Von der Ohe MR, Holst JJ, et al. Altered postprandial motility in chronic pancreatitis: role of malabsorption. Gastroenterology 1997; 112:1624-34.
    • (1997) Gastroenterology , vol.112 , pp. 1624-1634
    • Layer, P.1    Von Der Ohe, M.R.2    Holst, J.J.3
  • 25
    • 0032789177 scopus 로고    scopus 로고
    • Cholecystokinin secretion in patients with chronic pancreatitis and after different types of pancreatic surgery
    • Eddes EH, Masclee AAM, Gielkens HAJ, et al. Cholecystokinin secretion in patients with chronic pancreatitis and after different types of pancreatic surgery. Pancreas 1999; 19:119-25.
    • (1999) Pancreas , vol.19 , pp. 119-125
    • Eddes, E.H.1    Masclee, A.2    Gielkens, H.3
  • 26
    • 0009758898 scopus 로고
    • Diagnostic criteria for chronic pancreatitis
    • Committee of Diagnostic Criteria for Chronic Pancreatitis. Diagnostic criteria for chronic pancreatitis. Jpn J Gastroenterol 1983;80:1863-6.
    • (1983) Jpn J Gastroenterol , vol.80 , pp. 1863-1866
  • 27
    • 0034052374 scopus 로고    scopus 로고
    • Nationwide epidemiological survey of chronic pancreatitis in Japan
    • Lin Y, Tamakoshi A, Matsuno S, et al. Nationwide epidemiological survey of chronic pancreatitis in Japan. J Gastroenterol 2000; 35:136-41.
    • (2000) J Gastroenterol , vol.35 , pp. 136-141
    • Lin, Y.1    Tamakoshi, A.2    Matsuno, S.3
  • 28
    • 0033798641 scopus 로고    scopus 로고
    • The cholecystokinin antagonist proglumide has an analgesic effect in chronic pancreatitis
    • McCleane GJ. The cholecystokinin antagonist proglumide has an analgesic effect in chronic pancreatitis. Pancreas 2000; 21:324-5.
    • (2000) Pancreas , vol.21 , pp. 324-325
    • McCleane, G.J.1
  • 29
    • 0023139138 scopus 로고
    • Proglumide exhibits delta opioid agonist properties
    • Rezvani A, Stokes B, Rhoads HL, et al. Proglumide exhibits delta opioid agonist properties. Alcohol Drug Res 1987; 7:135-46.
    • (1987) Alcohol Drug Res , vol.7 , pp. 135-146
    • Rezvani, A.1    Stokes, B.2    Rhoads, H.L.3
  • 30
    • 0031755072 scopus 로고    scopus 로고
    • The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain
    • McCleane GJ. The cholecystokinin antagonist proglumide enhances the analgesic efficacy of morphine in humans with chronic benign pain. Anesth Analg 1998; 87:1117-20.
    • (1998) Anesth Analg , vol.87 , pp. 1117-1120
    • McCleane, G.J.1
  • 31
    • 0028305599 scopus 로고
    • Cholecystokinin receptor family: Molecular cloning, structure, and functional expression in rat, guinea pig, and human
    • Wank S, Posegna JR, De Weerth A. Cholecystokinin receptor family: molecular cloning, structure, and functional expression in rat, guinea pig, and human. Ann NY Acad Sci 1994; 713:49-66.
    • (1994) Ann NY Acad Sci , vol.713 , pp. 49-66
    • Wank, S.1    Posegna, J.R.2    De Weerth, A.3
  • 32
    • 0028845124 scopus 로고
    • Cholecystokinin receptors
    • Wank SA. Cholecystokinin receptors. Am J Physiol 1995; 269:G628-46.
    • (1995) Am J Physiol , vol.269
    • Wank, S.A.1
  • 33
    • 0029834048 scopus 로고    scopus 로고
    • Cholecystokinin receptors in human pancreas and gallbladder muscle: A comparative study
    • Tang C, Biemond I, Lamers CBHW. Cholecystokinin receptors in human pancreas and gallbladder muscle: a comparative study. Gastroenterology 1996; 111:1621-6.
    • (1996) Gastroenterology , vol.111 , pp. 1621-1626
    • Tang, C.1    Biemond, I.2    Lamers, C.B.H.W.3
  • 34
    • 0033056957 scopus 로고    scopus 로고
    • Mechanism of cholecystokinin-A-receptor antagonist on human pancreatic exocrine secretion
    • Funakoshi A, Fukamizu Y, Miyasaka K. Mechanism of cholecystokinin-A-receptor antagonist on human pancreatic exocrine secretion. Digestion 1999; 60(suppl 1):75-80.
    • (1999) Digestion , vol.60 , pp. 75-80
    • Funakoshi, A.1    Fukamizu, Y.2    Miyasaka, K.3
  • 35
    • 0032789176 scopus 로고    scopus 로고
    • Cholecystokinin A and B receptor mRNA expression in human pancreas
    • Nishimori I, Kamakura M, Fujikawa-Adachi K, et al. Cholecystokinin A and B receptor mRNA expression in human pancreas. Pancreas 1999; 19:109-13.
    • (1999) Pancreas , vol.19 , pp. 109-113
    • Nishimori, I.1    Kamakura, M.2    Fujikawa-Adachi, K.3
  • 36
    • 0025215942 scopus 로고
    • Effects of a cholecystokinin antagonist on intestinal phase of pancreatic and biliary responses in man
    • Hildebrand P, Beglinger G, Gyr K, et al. Effects of a cholecystokinin antagonist on intestinal phase of pancreatic and biliary responses in man. J Clin Invest 1990; 85:640-6.
    • (1990) J Clin Invest , vol.85 , pp. 640-646
    • Hildebrand, P.1    Beglinger, G.2    Gyr, K.3
  • 37
    • 0023009433 scopus 로고
    • Endogenous cholecystokinin drives gallbladder emptying in dogs
    • Shiratori K, Watanabe S, Chey WY, et al. Endogenous cholecystokinin drives gallbladder emptying in dogs. Am J Physiol 1986; 251:G553-8.
    • (1986) Am J Physiol , vol.251
    • Shiratori, K.1    Watanabe, S.2    Chey, W.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.