PARK6 is a common cause of familial parkinsonism

Neurological Sciences

Volumn 23, Issue SUPPL. 2, 2002, Pages

  Valente, E M ^k   Brancati, F ^a   Caputo, V ^a   Graham, E A ^b   Davis, M B ^b   Ferraris, A ^a   Breteler, M M B ^c   Gasser, T ^d   Bonifati, V ^e   Bentivoglio, A R ^f   De Michele, G ^g   Durr A ^h   Cortelli, P ⁱ   Filla, A ^g   Meco, G ^e   Oostra, B A ^c   Brice, A ^h   Albanese, A ^j   Dallapiccola, B ^a   Wood, N W ^b  

^a CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

^d UNIVERSITY OF MUNICH   (Germany)

^e SAPIENZA UNIVERSITY OF ROME   (Italy)

^f CATHOLIC UNIVERSITY   (Italy)

^g UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^h PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

ⁱ UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^j DEPARTMENT OF NEUROSURGERY   (Italy)

^k NONE

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Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PARK6 PROTEIN; PARKIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CHROMOSOME 1P; CLINICAL FEATURE; CLINICAL OBSERVATION; CONSANGUINEOUS MARRIAGE; CONTROLLED STUDY; DIFFERENTIAL DIAGNOSIS; DISEASE COURSE; DYSTONIA; EUROPE; FAMILY STUDY; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; HOMOZYGOSITY; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; ONSET AGE; PARKINSON DISEASE; PARKINSONISM; SOMNOLENCE;

EID: 18744380014     PISSN: 15901874     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100720200097     Document Type: Article

References (8)

1. Ishikawa A, Tsuji S (1996) Clinical analysis of 17 patients in 12 Japanese families with autosomal recessive type juvenile parkinsonism. Neurology 47:160-166
2. Takahashi H, Ohama E, Suzuki S et al (1994) Familial juvenile parkinsonism: clinical and pathological study in a family. Neurology 44:437-441
3. Kitada T, Asakawa S, Hattori N et al (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392:605-608
4. Shimura H, Hattori N Kubo S et al (2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nature Genet 25:302-305
5. Lücking CB, Dürr A, Bonifati V et al (2000) Association between early-onset Parkinson's disease and mutations in the parkin gene. New Engl J Med 342:1560-1567
6. Valente EM, Bentivoglio AR, Ialongo T et al (2001) Localization of a novel locus for autosomal recessive early onset parkinsonism (PARK6) on human chromosome 1p35-p36. Am J Hum Genet 68:895-900
7. Van Dujin CM, Dekker MCJ, Bonifati V et al (2001) PARK7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36. Am J Hum Genet 69:629-634
8. Valente EM, Brancati F, Fen-aris A et al (2002) PARK6-linked parkinsonism occurs in several European families. Ann Neurol 51:14-18