7-84 parathyroid hormone fragments are proportionally increased with the severity of uremic hyperparathyroidism

Clinical Nephrology

Volumn 63, Issue 5, 2005, Pages 351-355

  Chang, J M ^a   Lin, S P ^a   Kuo, H T ^a   Tsai, J C ^b   Tomino, Y ^c   Lai, Y H ^a   Chen, H C ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b Department of Internal Medicine   (Taiwan)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

1 84 whole PTH; Hemodialysis; Hyperparathyroidism; Intact PTH; Procollagen type I cross linked carboxy terminal telopeptide (ICTP); Type I procollagen carboxy terminal extension peptide (PICP)

Indexed keywords

BIOCHEMICAL MARKER; PARATHYROID HORMONE; PARATHYROID HORMONE[7-84]; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BONE REMODELING; BONE TURNOVER; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE SEVERITY; FEMALE; HEMODIALYSIS; HORMONE DETERMINATION; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; NON INVASIVE MEASUREMENT; OSSIFICATION; OSTEOLYSIS; PARATHYROID HORMONE BLOOD LEVEL; PREDICTION; RENAL OSTEODYSTROPHY; UREMIA;

EID: 18744379470     PISSN: 03010430     EISSN: None     Source Type: Journal    
DOI: 10.5414/CNP63351     Document Type: Article

References (22)

1. Avram MM, Sreedhara R, Avram DK, Muchnick RA, Fein P 1996 Enrollment parathyroid hormone level is a new marker of survival in hemodialysis and peritoneal dialysis therapy for uremia. Am J Kidney Dis 28: 924-930
2. Brossard JH, Cloutier M, Roy L, Lepage R, Gascon-Barre M, D'Amour P 1996 Accumulation of a non-(1-84) molecular form of parathyroid hormone (PTH) detected by intact PTH assay in renal failure: importance in the interpretation of PTH values. J Clin Endocrinol Metab 81: 3923-3929
3. Brossard JH, Lepage R, Cardinal H, Roy L, Rousseau L, Dorais C, D'Amour P 2000 Influence of glomerular filtration rate on non-(1-84) parathyroid hormone (PTH) detected by intact PTH assays. Clin Chem 46: 697-700
4. Coen G, Bonucci E, Ballanti P, Balducci A, Calabria S, Nicolai GA, Fischer MS, Lifrieri F, Manni M, Morosetti M, Moscaritolo E, Sardella D 2002 PTH 1-84 and PTH "7-84" in the noninvasive diagnosis of renal bone disease. Am J Kidney Dis 40: 348-354
5. D'Amour P, Palardy J, Bahsali G, Mallette LE, DeLean A, Lepage R 1992 The modulation of circulating parathyroid hormone immunoheterogeneity in man by ionized calcium concentration. J Clin Endocrinol Metab 74: 525-532
6. Divieti P, Inomata N, Chapin K, Singh R, Juppner H, Bringhurst FR 2001 Receptors for the carboxyl-terminal region of PTH(1-84) are highly expressed in osteocytic cells. Endocrinology 142: 916-925
7. Gao P, Scheibel S, D'Amour P, John MR, Rao SD, Schmidt-Gayk H, Cantor TL 2001 Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1-84: implications for improvement of accurate assessment of parathyroid function. J Bone Miner Res 16: 605-606
8. Guh JY, Chen HC, Chuang HY, Huang SC, Chien LC, Lai YH 2002 Risk factors and risk for mortality of mild hypoparathyroidism in hemodialysis patients. Am J Kidney Dis 39: 1245-1254
9. Habener JF, Kemper B, Potts JT Jr 1975 Calcium-dependent intracellular degradation of parathyroid hormone: a possible mechanism for the regulation of hormone stores. Endocrinology 97: 431-441
10. Jakob C, Zavrski I, Heider U, Bollow M, Schulz CO, Fleissner C, Eucker J, Michael R, Hamm B, Possinger K, Sezer O 2003 Serum levels of carboxy-terminal telopeptide of type-I collagen are elevated in patients with multiple myeloma showing skeletal manifestations in magnetic resonance imaging but lacking lytic bone lesions in conventional radiography. Clin Cancer Res 9: 3047-3051
11. John MR, Goodman WG, Gao P, Cantor TL, Salusky IB, Juppner H 1999 A novel immunoradiometric assay detects full-length human PTH but not amino-terminally truncated fragments: implications for PTH measurements in renal failure. J Clin Endocrinol Metab 84: 4287-4290
12. Lepage R, Roy L, Brossard JH, Rousseau L, Dorais C, Lazure C, D'Amour P 1998 A non-(1-84) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples. Clin Chem 44: 805-809
13. Llach F 1995 Secondary hyperparathyroidism in renal failure: the trade-off hypothesis revisited. Am J Kidney Dis 25: 663-679
14. Martin KJ, Gonzalez EA 2001 The evolution of assays for parathyroid hormone. Curr Opin Nephrol Hypertens 10: 569-574
15. Melkko J, Niemi S, Risteli L, Risteli J 1990 Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen. Clin Chem 36: 1328-1332
16. Monier-Faugere MC, Geng Z, Mawad H, Friedler RM, Gao P, Cantor TL, Malluche HH 2001 Improved assessment of bone turnover by the PTH-(1-84)/large C-PTH fragments ratio in ESRD patients. Kidney Int 60: 1460-1468
17. Nakanishi S, Kazama JJ, Shigematsu T, Iwasaki Y, Cantor TL, Kurosawa T, Fukagawa M 2001 Comparison of intact PTH assay and whole PTH assay in long-term dialysis patients. Am J Kidney Dis 38 (4 Suppl 1): S172-S174
18. Nussbaum SR, Zahradnik RJ, Lavigne JR, Brennan GL, Nozawa-Ung K, Kim LY, Keutmann HT, Wang CA, Potts JT Jr, Segre GV 1987 Highly sensitive two-site immunoradiometric assay of parathyrin and its clinical utility in evaluating patients with hypercalcemia. Clin Chem 33: 1364-1367
19. Quarles LD, Lobaugh B, Murphy G 1992 Intact parathyroid hormone overestimates the presence and severity of parathyroid-mediated osseous abnormalities in uremia. J Clin Endocrinol Metab 75: 145-150
20. Sherrard DJ, Hercz G, Pei Y, Maloney NA, Greenwood C, Manuel A, Saiphoo C, Fenton SS, Segre GV 1993 The spectrum of bone disease in end-stage renal failure - an evolving disorder. Kidney Int 43: 436-442
21. Slatopolsky E, Finch J, Clay P, Martin D, Sicard G Singer G, Gao P, Cantor T, Dusso A 2000 A novel mechanism for skeletal resistance in uremia. Kidney Int 58: 753-761
22. Urena P, De Vernejoul MC 1999 Circulating biochemical markers of bone remodeling in uremic patients. Kidney Int 55: 2141-2156