Viral vector delivery of parkin generates model results in rats

Gene Therapy

Volumn 12, Issue 9, 2005, Pages 727-729

  Kirik, Deniz ^a   Björklund, Anders ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LENTIVIRUS VECTOR; MITOCHONDRIAL ENZYME; PARKIN; UBIQUITIN PROTEIN LIGASE;

CYTOTOXICITY; DOPAMINERGIC NERVE CELL; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; GENE DUPLICATION; GENE MUTATION; GENE OVEREXPRESSION; GENE TRANSFER; GENETIC TRANSDUCTION; HUMAN; IN VIVO STUDY; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; NOTE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; ANIMAL; DISEASE MODEL; GENE THERAPY; GENETICS; LENTIVIRINAE; METHODOLOGY; RAT;

LENTIVIRUS;

ANIMALS; DISEASE MODELS, ANIMAL; GENE THERAPY; LENTIVIRUS; PARKINSON DISEASE; RATS; UBIQUITIN-PROTEIN LIGASES;

EID: 18744370733     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302497     Document Type: Note

References (7)

1. Lo Bianco C et al. Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an alpha-synuclein rat model of Parkinson's disease. Proc Natl Acad Sci USA 2004; 101: 17510-17515.
2. Shimura H et al. Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease. Science 2001; 293: 263-269.
3. Yang Y et al. Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila. Neuron 2003; 37: 911-924.
4. Fujiwara H et al. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 2002; 4: 160-164.
5. Conway KA et al. Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 2001; 294: 1346-1349.
6. Cuervo AM et al. Impaired degradation of mutant alpha synuclein by chaperon-mediated autophagy. Science 2004; 305: 1292-1295.
7. Lo Bianco C et al. Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease. Neurobiol Dis 2004; 17: 283-289.