Protective effect of Jakyak-Gamcho-Tang extract and its constituents against t-BHP-induced oxidative damage in HT22 cells

American Journal of Chinese Medicine

Volumn 33, Issue 2, 2005, Pages 181-189

  Kang, Tai Hyun ^a   Baek, Hum Young ^b   Kim, Youn Chul ^a  

^a Wonkwang University   (South Korea)

^b Jung Woo Pharmaceutical Co Ltd   (South Korea)

Author keywords

Antioxidant; Glycyrrhizae radix; HT22 cells; Jakyak Gamcho Tang; Paeoniae radix; Tert butyl hydroperoxide

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; GLYCYRRHIZA EXTRACT; JAKYAK GAMCHO TANG EXTRACT; PAEONIA RADIX; PLANT EXTRACT; SHAOYAO GANCAO TANG; SUPEROXIDE; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DAMAGE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATION;

ANTIOXIDANTS; CELL CULTURE TECHNIQUES; DRUGS, CHINESE HERBAL; HIPPOCAMPUS; HUMANS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; TERT-BUTYLHYDROPEROXIDE;

EID: 18744363369     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X05002850     Document Type: Article

References (17)

1. Behl, C., J.B. Davis, R. Lesley and D. Schubert. Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77: 817-827, 1994.
2. Blois, M.S. Antioxidant determination by the use of a stable free radical. Nature 181: 1199-1200, 1958.
3. Coly, J.T. and P. Puttfarcken. Oxidative stress, glutamate and neurodegenerative disorders. Science 262: 689-695, 1993.
4. Davies, M.J. Detection of peroxyl and alkoxyl radicals produced by reaction of hydroperoxides with rat liver microsomal fractions. Biochem. J. 257: 603-606, 1989.
5. Gebhardt, R. Antioxidative and protective properties of extracts form leaves of the artchoke (Cynara scolymus L.) against hydroperoxide-induced oxidative stress in cultured rat hepatocytes. Toxicol. Appl. Pharmacol. 144: 279-286, 1997.
6. He, J.X., T. Akao, T. Nishino and T. Tani. The influence of commonly prescribed synthetic drugs for peptic ulcer on the pharmacokinetic fate of glycyrrhizin from Shaoyao-Gancao-tang. Biol. Pharm. Bull. 24: 1395-1399, 2001.
7. Hogberg, J., S. Orrenius and P. O'Brien. Further studies on lipid peroxide formation in isolated hepatocytes. Eur. J. Biochem. 59: 449-455, 1975.
8. Lee, S.M., M.L. Li, Y.C. Tse, S.C. Leung, M.M. Lee, S.K. Tsui, K.P. Fung, C.Y. Lee and M.M. Waye. Paeonia Radix, a Chinese herbal extract, inhibits hepatoma, cells growth by inducing apoptosis in a p53 independent pathway. Life Sci. 71: 2267-2277, 2002.
9. Makkesbery, W.R. Oxidative stress hypothesis in Alzhiemer's disease. Free Radic. Biol. Med. 23: 134-147, 1997.
10. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63, 1983.
11. Nishizawa, M., T. Yamagishi, G. Nonaka, I. Nishioka, T. Nagasawa and H. Oura. Tannins and related compounds. XII. Isolation and characterization of galloylglucoses from Paeoniae Radix and their effects on urea-nitrogen concentration in rat serum. Chem. Pharm. Bull. 31: 2593-2600, 1983.
12. Okubo, T., F. Nagai, T. Seto, K. Satoh, K. Ushiyama and I. Kano. The inhibition of pheylhydroquinone-induced oxidative DNA cleavage by constituents of Moutan Cortex and Paeoniae Radix. Chem. Pharm. Bull. 23: 199-203, 2000.
13. Robak, J. and R.J. Gryglewski. Flavonoids are scavengers of superoxide scavengers and antioxidants. Biochem. Pharmacol. 37: 837-841, 1988.
14. Simonian, N.A. and J.T. Coly. Oxidative stress in neurodegenerative diseases. Ann. Rev. Pharmacol. 36: 83-106, 1996.
15. Tanaka, T., M. Kataoka, N. Tsuboi and I. Kouno. New monoterpene glycoside esters and phenolic constituents of Paeoniae Radix, and increase of water solubility of proanthocyanidins in the presence of paeoniflorin. Chem. Pharm. Bull. 48: 201-207, 2000.
16. Tanaka, T., M. Fukumori, T. Ochi and I. Kouno. Paeonianins A-E, new dimeric and monomeric ellagitannins from the fruits of Paeonia lactiflora. J. Nat. Prod. 66: 759-763, 2003.
17. Thornalley, P., R.J. Trotta and A. Stern. Free radical involvement in the oxidative phenomena induced by tert-butyl hydroperoxide in erythrocytes. Biochim. Biophys. Acta 759: 16-22, 1983.