Novel benzthiodiazepinones as antiherpetic agents: SAR improvement of therapeutic index by alterations of the seven-membered ring

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 20, 2002, Pages 2981-2983

  Hamilton, Harriet W ^a   Nishiguchi, Gisele ^a   Hagen, Susan E ^a   Domagala, John D ^a   Weber, Peter C ^a   Gracheck, Stephen ^a   Boulware, Stefanie L ^a   Nordby, Eric C ^a   Cho, Hidetsura ^b   Nakamura, Takeshi ^b   Ikeda, Satoru ^b   Watanabe, Wataru ^b  

^a PFIZER INC   (United States)

^b JAPAN TOBACCO INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BENZTHIODIAZEPINONE; DIAZEPINE DERIVATIVE; PD 146626; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL ASSAY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG POTENCY; HERPES SIMPLEX VIRUS 1; HUMAN; MOLECULE; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

ALKYLATION; ANTIVIRAL AGENTS; AZEPINES; HERPESVIRUS 1, HUMAN; INDICATORS AND REAGENTS; LAC OPERON; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES; VIRUS REPLICATION;

EID: 18644383535     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00578-4     Document Type: Article

References (2)

1. Boulware S.L., Bronstein J.C., Nordby E.C., Weber P.C. Antiviral Res. 51:2001;111.
2. Khatana S.S., Boschelli D.H., Kramer J.B., Connor D.T., Barth H., Stoss P. J. Org. Chem. 61:1996;6060.