Development of an electrical resistance tomography reactor for pharmaceutical processes

Canadian Journal of Chemical Engineering

Volumn 83, Issue 1, 2005, Pages 11-18

  Ricard, François ^a   Brechtelsbauer, Clemens ^a   Xu, Yun ^b   Lawrence, Chris ^b   Thompson, Duncan ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Electrical resistance tomography (ERT); Instrumentation; Mixing; Pharmaceutical; Stirred tank reactor

Indexed keywords

CHEMICAL REACTORS; DRUG PRODUCTS; OPTIMIZATION; REACTION KINETICS; SPECTROSCOPIC ANALYSIS; TANKS (CONTAINERS);

ACTIVE PHARMACEUTICAL INGREDIENTS (API); PHARMACEUTICAL PROCESSES; REACTOR GEOMETRIES; TOMOGRAPHIC SENSORS;

ELECTRIC IMPEDANCE TOMOGRAPHY;

STIRRED TANK;

EID: 18644383317     PISSN: 00084034     EISSN: None     Source Type: Journal    
DOI: 10.1002/cjce.5450830104     Document Type: Article

References (36)

1. Barber, C.D., B.H. Brown and I.L. Freeston, "Imaging Spatial Distributions of Resistivity Using Applied Potential Tomography", Electron. Lett. 19, 933-935 (1983).
2. Beck, M.S. and R.A. Williams, "Process Tomography: a European Innovation and Its Applications", Meas. Sci. Technol. 7, 215-224 (1996).
3. Bolton, G.T., C.H. Qiu and M. Wang, "A Novel Electrical Tomography Sensor for Monitoring the Phase Distribution in Industrial Reactors", Proceedings of the 7th UK Conference on Mixing, Bradford, UK (2002).
4. Bourne, J.R., O. Dossenbach, and T. Post, "Local and Average Mass and Heat Transfer Generated by Pfaudler Type Impellers", IChemE, Symposium 89, 177-192 (1984).
5. Brown, B., "Medical Impedance Tomography and Process Impedance Tomography: A Brief Review", Meas. Sci. Technol. 12, 991-996 (2001).
6. Campolo, M. and A. Soldati, "Appraisal of Fluid Dynamic Efficiency of Retreated Blade and Turbofoil Impellers in Industrial Size CSTRs", Ind. Eng. Chem. Res. 41, 1370-1377 (2002).
7. Cooke, M., G.T. Bolton, D.H. Jones and D. Housley, "Demonstration of a Novel Retrofit Tomography Baffle Cage for Gas Liquid Mixing Studies Under Intense Operating Conditions", Proceedings of the Second World Congress on Industrial Process Tomography, Hannover, Germany (2001).
8. Dickin, F.J. and M. Wang, "Electrical Resistance Tomography for Process Applications", Meas. Sci. Technol. 7, 247-260 (1996).
9. Dyakowski, T., M. Miko, D. Vlaev, R. Mann, G.W. Follows, A. Boxman and M.P.W. Wilson, "Imaging Nylon Polymerisation by Applying Electrical Tomography", Proceedings of the 1st World Congress on Industrial Process Tomography, Buxton, 383-387 (1999).
10. DynoChem PFD, It's about time, www.scale-up.com/Dynochem_info.htm, (2003).
11. Hattou, S. and J. Costes, "Power, Macromixing and Micromixing in de Dietrich Standard Reactors", Récents Progrés en Génie des Procédés 11 (51), 389-396 (1997).
12. Hoyle, B.S., X., Jia, F.J.W., Podd, H.I. Schlaberg, H.S. Tan, M. Wang, R.M. West, R.A. Williams and T.A. York, "Design and Application of a Multi-modal Process Tomography System", Meas. Sci. Technol. 12, 1157-1165 (2001).
13. Hua, P., J.G. Webster, and W.J. Tomkins, "Effect of The Measurement Method on Noise Handling and Image Quality of EIT Imaging", IEEE Trans. Biomed. Eng. 40, 29-34 (1993).
14. Izutsu, K., "Electrochemistry in Non-aqueous Solutions", Wiley-VCH, Weinheim, Germany (2002).
15. Julabo, "Silicone oil Thermal H - Safety Data Sheet and Product Information", GE Bayer silicones, www.julabo.de, (2003).
16. Justice, J.C., "Comprehensive Treatise of Electrochemistry" 5 (3), New York, Plenum Press, NY (1983).
17. Kotre, C.J., "EIT Image Reconstruction Using Sensitivity Weighted Filtered Backprojection", Physiol. Meas. 15 (supp 2A), 125-136 (1994).
18. Mann, R., F.J. Dickin, M. Wang, T. Dyakowski, R.A. Williams, R.B. Edwards, A.E. Forrest and P.J. Holden, "Application of electrical resistance tomography to interrogate mixing processes at plant scale", Chemical Engineering Science 52, 2087-2097 (1997).
19. Mann, R. and M. Wang, "Electrical Process Tomography: Simple and Inexpensive Techniques for Process Imaging" Meas. and Control 30 (7), 206-211 (1997).
20. Parker, D.J., M.R. Hawkesworth and T.D. Beynon, "Process Applications of Emission Tomography", Chem. Eng. J. 56, 109-117 (1995).
21. Pinheiro, P.A. da T., "Investigation of Forward Problem Solvers and Data Collection Methods in Electrical Impedance Tomography", MSc dissertation, UMIST, UK (1994).
22. Primrose, K. and C. Qiu, "Performance and Application Studies of an ERT System", Proceedings of the 1st World Congress in Industrial Process Tomography, Buxton, UK 133-139 (1999).
23. Plaskowski, A., M.S. Beck, M. Byars, T. Dyakowski, R. He, S.J. Wang, R.C. Waterfall and W.Q. Yang, "Industrial Application of Electrical Capacitance Tomography", Pomiary Automatyka Kontrola 42, 113-115 (1996).
24. Rao, S., K. Zhu, C.H. Wang and S. Sundaresan, "Electrical Capacitance Tomography Measurements on the Pneumatic Conveying of Solids", Ind. Eng. Chem. Res. 40 (20), 4216-4226 (2001).
25. Schoenemann, E., H. Hahn and A. Bracht, "Bestimmung Kinetischer Parameter Aus Nichtisothermen Leitfaehigkeitsmessungen Nach Einer Integralmethode", Thermochimica Acta 185, 171-176 (1991).
26. Slater, L., A. Binley, R. Versteeg, G. Cassiani, R. Birken, and S. Sandberg, "A 3D ERT Study of Solute Transport in a Large Experimental Tank", Journal of Applied Geophysics 49, 211-229 (2002).
27. Vandeginste, B., W. Derks and G. Kateman, "Multicomponent Self-Modelling Curve Resolution in High-Performance Liquid Chromatography by Iterative Target Transformation Analysis", Analytica Chimica Acta 173, 253-264 (1985).
28. Vershuren, I., J. Wijers and J. Keurentjes, "Mixing with a Pfaudler Type Impeller: the Effect of Micromixing on Reaction Selectivity in the Production of Fine Chemicals", Proceedings of the 10th European Conference on Mixing, Delft, The Netherlands 69-75 (2000).
29. Wang, M., "Inverse Solutions for Electrical Impedance Tomography Based on Conjugate Gradient Methods", Meas. Sci. Tech. 13, 101-117 (2002).
30. Wang, M., F.J. Dickin and M.S. Beck, "Signal Phase Shift and Compensation in Resistive Electrical Impedance Tomography", Process Tomography - for a strategy industrial application, 75-78 (1993).
31. Wang, M., Dickin, F. J. and R.A. Williams, "The Grouped-node Technique as a Means of Handling Large Electrode Surfaces in Electrical Impedance Tomography", Physiological Measurement 16, 219-226 (1995).
32. Williams, R.A. and M.S. Beck, Eds., "Process Tomography: Principles, Techniques and Applications", Butterworth-Heineman, Oxford, UK (1995).
33. Williams, R.A. and D.M. Scott, Eds., "Frontiers in Industrial Process Tomography", Engineering Foundation, New York, NY (1995).
34. Xie, C.G., "Review of Image Reconstruction Methods for Process Tomography." Process Tomography: a Strategy for Industrial Exploitation, UMIST, Manchester, Eds. M.S. Beck, E. Campogrande, M. Morris, R.A. Williams, R.C. Waterfall, 115-119 (1993).
35. York, T., "Status of Electrical Tomography in Industrial Applications", J. Electronic Imaging 10, 608-619 (2001).
36. Yorkey, T.J., J.G. Webster and W.J. Tompkins, "Comparing reconstruction algorithms for electrical impedance tomography", IEEE Trans. Biomed. Eng. 34, 843-851 (1987).