HPC2/ELAC2 polymorphisms and prostate cancer risk: Analysis by age of onset of disease

British Journal of Cancer

Volumn 87, Issue 8, 2002, Pages 905-908

  Meitz, J C ^a   Edwards, S M ^a   Easton, D F ^a   Murkin, A ^a   Ardern Jones, A ^a   Jackson, R A ^a   Williams, S ^a   Dearnaley, D P ^a   Stratton, M R ^a   Houlston, R S ^a   Eeles, R A ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

ELAC2; HPC2; Polymorphisms; Prostate cancer (PrCa) susceptibility

Indexed keywords

ALANINE; LEUCINE; SERINE; THREONINE;

ADULT; AGED; ARTICLE; CANCER RISK; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CONTROLLED STUDY; ELAC2 GENE; FAMILY HISTORY; GENE; GENETIC POLYMORPHISM; GENOTYPE; HPC2 GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; POPULATION RESEARCH; PRIORITY JOURNAL; PROSTATE CANCER; UNITED KINGDOM;

ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; DNA; DNA, NEOPLASM; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MUTATION; NEOPLASM PROTEINS; ODDS RATIO; POLYMORPHISM, GENETIC; PROSTATIC NEOPLASMS; RISK FACTORS; VARIATION (GENETICS);

EID: 18644380642     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600564     Document Type: Article

References (10)

1. Carter BS, Beaty TH, Steinberg GD, Childs B, Walsh PC (1992) Mendelian inheritance of familial prostate cancer. Proc Natl Acad Sci USA 89: 3367-3371
2. Eeles RA, the UK Familial Prostate Study Co-ordinating Group, the CRC/BPG UK Familial Prostate Cancer Study Collaborators (1999) Genetic predisposition to prostate cancer. Prostate Cancer and Prostatic Diseases 2: 9-15
3. Edwards SM, Dearnaley DP, Ardern-Jones A, Hamoudi RA, Easton DF, Ford D, Shearer R, Dowe A, Eeles RA (1997) No germline mutations in the dimerization domain of MXI1 in prostate cancer clusters. The CRC/BPG UK Familial Prostate Cancer Study Collaborators. Cancer Research Campaign/British Prostate Group. Br J Cancer 76(8): 992-1000
4. Rebbeck TR, Walker AH, Zeigler-Johnson C, Weisburg S, Martin AM, Nathanson KL, Wein AJ, Malkowicz SB (2000) Association of HPC2/ELAC2 genotypes and prostate cancer. Am J Hum Genet 67: 1014-1019
5. Rökman A, Ikonen T, Mononen N, Autio V, Matikainen MP, Koivisto PA, Tammela TLJ, Kallioniemi OP, Schleutker J (2001) ELAC2/HPC2 involvement in hereditary and sporadic prostate cancer. Cancer Res 61: 6038-6041
6. Suarez BK, Gerhard DS, Lin J, Haberer B, Nguyen L, Kesterson NK, Catalona WJ (2001) Polymorphisms in the prostate cancer susceptibility gene HPC2/ELAC2 in multiplex families and healthy controls. Cancer Res 61(13): 4982-4984
7. Tavtigian SV, Simard J, Teng DH, Abtin V, Baumgard M, Beck A, Camp NJ, Carillo AR, Chen Y, Dayananth P, Desrochers M, Dumont M, Farnham JM, Frank D, Frye C, Ghaffari S, Gupte JS, Hu R, Iliev D, Janecki T, Kort EN, Laity KE, Leavitt A, Leblanc G, McArthur-Morrison J, Pederson A, Penn B, Peterson KT, Reid JE, Richards S, Schroeder M, Smith R, Snyder SC, Swedlund B, Swensen J, Thomas A, Tranchant M, Woodland AM, Labrie F, Skolnick MH, Neuhausen S, Rommens J, Cannon-Albright LA (2001) A candidate prostate cancer susceptibility gene at chromosome 17p. Nat Genet 27(2): 172-180
8. Vesprini D, Nam RK, Trachtenberg J, Jewett MA, Tavtigian SV, Emami M, Ho M, Toi A, Narod SA (2001) HPC2 variants and screen-detected prostate cancer. Am J Hum Genet 68(4): 912-917
9. Wang L, McDonnell SK, Elkins DA, Slager SL, Christensen E, Marks AF, Cunningham JM, Peterson BJ, Jacobsen SJ, Cerhan JR, Blute ML, Schaid DJ, Thibodeau SN (2001) Role of HPC2/ELAC2 in hereditary prostate cancer. Cancer Res 61(17): 6494-6499
10. Xu J, Zheng SL, Carpten JD, Nupponen NN, Robbins CM, Mestre J, Moses TY, Faith DA, Kelly BD, Isaacs SD, Wiley KE, Ewing CM, Bujnovszky P, Chang B, Bailey-Wilson J, Bleecker ER, Walsh PC, Trent JM, Meyers DA, Isaacs WB (2001) Evaluation of linkage and association of HPC2/ELAC2 in patients with familial or sporadic prostate cancer. Am J Hum Genet 68 (4): 901-911