Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro

Chemico-Biological Interactions

Volumn 142, Issue 1-2, 2002, Pages 119-134

  Kapetanovic, Izet M ^a,b,f   Torchin, Cynthia D ^b   Strong, John M ^a   Yonekawa, Wayne D ^b   Lu, Chuang ^c   Li, Albert P ^c   Dieckhaus, Christine M ^d   Santos, Webster L ^d   Macdonald, Timothy L ^d   Sofia, R Duane ^e   Kupferberg, Harvey J ^b  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c In Vitro Technologies Inc   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e Wallace Laboratories   (United States)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Aldehyde dehydrogenase; Atropaldehyde; Glutathione; Glutathione transferase; Hepatocytes; Reactive metabolites

Indexed keywords

3 CARBAMOYL 2 PHENYLPROPIONIC ACID; 4 HYDROXY 5 PHENYLTETRAHYDRO 1,3 OXAZIN 2 ONE; 4 HYDROXYNONENAL; ALDEHYDE DEHYDROGENASE; ATROPALDEHYDE; DRUG METABOLITE; FELBAMATE; GLUTATHIONE ETHYL ESTER; GLUTATHIONE TRANSFERASE; KETONE DERIVATIVE; PROPIONIC ACID DERIVATIVE; TOXIN; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DETOXIFICATION; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG HYDROXYLATION; DRUG INHIBITION; DRUG METABOLISM; DRUG STRUCTURE; DRUG TRANSFORMATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LIVER; SPECIES COMPARISON; TARGET ORGAN;

ALDEHYDE DEHYDROGENASE; ALDEHYDES; ANTICONVULSANTS; ENZYME INHIBITORS; GLUTATHIONE TRANSFERASE; HUMANS; LIVER; MICROSOMES, LIVER; PROPYLENE GLYCOLS;

EID: 18644378714     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(02)00058-3     Document Type: Article

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