Synthesis and antiaggregant properties of Stabilized analogues of polyunsaturated fatty acid metabolites

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 18, 2002, Pages 2511-2514

  Hachem, Ali ^a   Roussel, Patrick ^a   Ménager, Eric ^a   Grée, Danielle ^a   Le Floc'h, Yves ^a   Grée, René ^a   Cerletti, Chiara ^b   Rolland, Yves ^c   Simonet, Serge ^d   Verbeuren, Tony ^d  

^a UNIV RENNES   (France)

^b Consorzio Mario Negri Sud ^*  (Italy)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^d INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID DERIVATIVE; RAMATROBAN;

ANIMAL CELL; AROMATIZATION; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; THROMBOCYTE AGGREGATION; WITTIG REACTION;

ANIMALS; CELLS, CULTURED; FATTY ACIDS, UNSATURATED; HUMANS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RABBITS;

EID: 18644375089     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00507-3     Document Type: Article

References (12)

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7. f=0.42, after three elutions.
8. Starting from 7Z, it was possible to replace the acidic function in position 1 by various functional groups. The synthesis of such analogues will be described in the full paper.
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11. f=0.21.
12. Abstract