Alpha-fetoprotein (AFP)- and des-gamma-carboxy prothrombin (DCP)- producing adenocarcinoma of the stomach with liver metastasis in a patient with chronic hepatitis C

Internal Medicine

Volumn 44, Issue 4, 2005, Pages 294-298

  Sohda, Tetsuro ^b   Tomioka, Yoshitaka ^b   Inomata, Shinjiro ^b   Morita, Isamu ^b   Eguchi, Koichi ^b   Aoyagi, Kunihiko ^b   Watanabe, Hiroshi ^b   Nakamura, Shotaro ^a   Sakisaka, Shotaro ^b  

^a Nakamura Medical Clinic   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

Author keywords

AFP mRNA; Alpha fetoprotein (AFP); Des gamma carboxy prothrombin (DCP); Gastric cancer; Hepatitis C virus (HCV); Immunohistochemistry

Indexed keywords

ALPHA FETOPROTEIN; AMINOTRANSFERASE; ANTINEOPLASTIC AGENT; DECARBOXYPROTHROMBIN; HEPATITIS C ANTIBODY; LACTATE DEHYDROGENASE; MESSENGER RNA; VIRUS RNA;

ADULT; ARTICLE; CANCER CELL; CANCER DIAGNOSIS; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DEATH; ECHOGRAPHY; GASTROSCOPY; HEPATITIS C; HOSPITAL ADMISSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MALE; PHYSICAL EXAMINATION; PROTEIN EXPRESSION; STOMACH ADENOCARCINOMA; STOMACH BIOPSY;

ADENOCARCINOMA; ALPHA-FETOPROTEINS; BIOLOGICAL MARKERS; BIOPSY; DIAGNOSIS, DIFFERENTIAL; FATAL OUTCOME; FOLLOW-UP STUDIES; GASTROSCOPY; GENE EXPRESSION REGULATION, NEOPLASTIC; HEPATITIS C, CHRONIC; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROTEIN PRECURSORS; PROTHROMBIN; RNA, MESSENGER; STOMACH NEOPLASMS; TOMOGRAPHY, X-RAY COMPUTED; TUMOR MARKERS, BIOLOGICAL;

EID: 18644362101     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.44.294     Document Type: Article

References (22)

1. Sakisaka S, Watanabe M, Tateishi H, et al. Erythropoietin production in hepatocellular carcinoma cells associated with polycythemia: Immunohistochemical evidence. Hepatology 18: 1357-1362, 1993.
2. McIntire KR, Waldmann TA, Moertel CG, Go VL. Serum α-fetoprotein in patients with neoplasms of the gastrointestinal tract. Cancer Res 35: 991-996, 1975.
3. Chang Y-C, Nagasue N, Abe S, Kohno H, Kumar DD, Nakamura T. α-fetoprotein producing early gastric cancer with liver metastasis: report of three cases. Gut 32: 542-545, 1991.
4. Chang Y-C, Nagasue N, Abe S, Taniura H, Kumar DD, Nakamura T. Comparison between the clinicopathological features of AFP-positive and AFP-negative gastric cancers. Am J Gastroenterol 87: 321-325, 1992.
5. Kudo M, Takamine Y, Nakamura K, et al. Des-γ-cafboxy prothrombin (PIVKA-II) and α-fetoprotein producing IIc-type early gastric cancer. Am J Gastroenterol 87: 1859-1862, 1992.
6. Hyodo T, Kawamoto R. Double cancer of the stomachs one AFP-producing tumor. J Gastroenterol 31: 851-854, 1996.
7. Ando E, Oriishi T, Toyonaga A, et al. Alpha-fetoprotein- and des-gamma-carboxy-prothrombin-producing advanced gastric cancer. Eur J Gastroenterol Hepatol 14: 687-691, 2002.
8. Matsumura M, Niwa Y, Hikiba Y, et al. Sensitive assay for detection of hepatocellular carcinoma associated gene transcription (alpha-fetoprotein mRNA) in blood. Biochem Biophysic Res Commun 207: 813-818, 1995.
9. Ijichi M, Takayama T, Matsumura M, Shiratori Y, Omata M, Makuuchi M. α-fetoprotein mRNA in the circulation as a predictor of postsurgical recurrence of hepatocellular carcinoma: a prospective study. Hepatology 35: 853-860, 2002.
10. Fujiyama S, Morishita T, Hashiguchi O, Sato T. Plasma abnormal prothrombin (des-γ-carboxy prothrombin) as a marker for hepatocellular carcinoma. Cancer 61: 1621-1628, 1988.
11. Inoue T, Takada T, Takada M, et al. A case of PIVKA-II and AFP producing gastric carcinoma. Nippon Shokakibyo Gakkai Zasshi 91: 84-88, 1994 (in Japanese).
12. Oinuma T, Kawano M, Ogonuki H, et al. A case of gastric cancer with liver metastasis showing positive immunohistochemical staining of PIVKA-II on the stomach and liver. Nippon Shokakibyo Gakkai Zasshi 91: 1022-1026, 1994 (in Japanese).
13. Ishii T, Ozasa R, Miyajima N, et al. A case of AFP and PIVKA-II producing gastric carcinoma forming a massive tumor embolus in the portal vein. Nippon Shokakibyo Gakkai Zasshi 99: 275-281, 2002 (in Japanese).
14. Okuse C, Yotsuyanagi H, Takahashi Y, et al. Gastric cancer with liver metastasis producing α-fetoprotein (AFP and protein induced by vitamin K absence or antagonist II (PIVKA-II) a case report. Nippon Shokakibyo Gakkai Zasshi 100: 28-34, 2003 (in Japanese).
15. Takahashi Y, Inoue T. Des-γ carboxy prothrombin (PIVKA-II) and α-fetoprotein producing gastric cancer with multiple liver metastases. Pathol Int 53: 236-240, 2003.
16. Ishikura H, Kifimoto K, Shamoto M, et al. Hepatoid adenocarcinomas of the stomach: an analysis of seven cases. Cancer 58: 119-126, 1986.
17. Matsunou H, Konishi F, Jalal RE, Yamamichi N, Mukawa A. Alpha-fetoprotein-producing gastric carcinoma with enteroblastic differentiation. Cancer 73: 534-540, 1994.
18. Koizumi W, Kurihara M, Nakano S, Hasegawa K. Phase II study of S-1, a novel oral derivative of 5-fluorouracil, in advanced gastric cancer. For the S-1 Cooperative Gastric Cancer Study Group. Oncology 58: 191-197, 2000.
19. Sakata Y, Ohtsu A, Horikoshi N, Sugimachi K, Mitachi Y, Taguchi T. Late phase II study of novel oral fluoropyrimidine anticancer drug S-1 (1 M tegafur-0.4 M gimestat-1M otastat potassium) in advanced gastric cancer patients. Eur J Cancer 34: 1715-1720, 1998.
20. Osugi H, Takada N, Takemura M, et al. Oral fluoropyrimidine anticancer drug TS-1 for gastric cancer patients with peritoneal dissemination. Oncol Rep 9: 811-815, 2002.
21. Okazaki M, Yamamura J, Kawasaki Y, et al. A case of advanced gastric cancer producing alpha fetoprotein with multiple liver metastases responding to TS-1 after TAE. Gan To Kagaku Ryoho (Jpn J Cancer Chemother) 28: 2073-2077, 2001 (in Japanese).
22. Fujita H, Yoshioka I, Iguchi M, et al. A patient with advanced gastric cancer in the gastric tube whose QOL was improved by TS-1. Gan To Kagaku Ryoho (Jpn J Cancer Chemother) 29: 443-447, 2002 (in Japanese).