Pilot clinical trial of the combination of hydroxyurea and didanosine in HIV-1 infected individuals

Antiviral Research

Volumn 29, Issue 1, 1996, Pages 111-113

  Biron, Francois ^a   Lucht, Frédéric ^b   Peyramond, Dominique ^a   Fresard, Anne ^b   Vallet, Thierry ^c   Nugier, Fabienne ^c   Grange, Jacques ^d   Malley, Serge ^d   Hamedi Sangsari, Farid ^c   Vila, Jorge ^c,d  

^a CROIX ROUSSE HOSPITAL   (France)

^b SERVICE DE NEUROLOGIE   (France)

^c Co de Developpement Aguettant SA ^*  (France)

^d INSERM   (France)

Author keywords

Didanosine; HIV 1; Hydroxyurea

Indexed keywords

CD4 ANTIGEN; DIDANOSINE; HYDROXYUREA; VIRUS RNA;

ADULT; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 18544411156     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-3542(95)00931-0     Document Type: Conference Paper

References (6)

1. Malley, S., Grange, J., Hamedi-Sangsari, F. and Vila, J. (1994a) Suppression of HIV production in resting lymphocytes by combining didanosine and hydroxamate compounds. Lancet 343, 1292.
2. Malley, S., Grange, J., Hamedi-Sangsari, F. and Vila, J. (1994b) Synergistic anti-HIV effect of hydroxamate compounds with 2′, 3′-dideoxyinosine in infected resting human lymphocytes. Proc. Natl. Acad. Sci. USA 91, 11017-11021.
3. Lori, F., Malykh, A., Cara, A. et al. (1994) Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication, Science 266, 801-805.
4. Biron, F., Lucht, F., Peyramond, D., Fresard, A., Vallet, T., Nugier, F., Grange, J., Malley, S., Hamedi-Sangsari, F. and Vila, J. (1995) Anti-HIV activity of the combination of didanosine and hydroxyurea in HIV-1 infected individuals. J. Aids Human Retrovirol. 10:1, 36-40
5. Rouzioux, C., Fuel, J., Agut, H. et al. (1992) Comparative assessment of quantitative HIV viræmia assays. AIDS 6, 373-377
6. Donehower, R. (1992) An overview of the clinical experience with Hydroxyurea. Semin. Oncol. 19 (Suppl. 9), 11-19.