Synthesis and biological activity of novel thiazolidinediones

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 19, 1998, Pages 2725-2730

  Prabhakar, C ^a   Madhusudhan, G ^a   Sahadev, K ^a   Maheedhara Reddy, Ch ^a   Sarma, M R ^a   Om Reddy, G ^a   Chakrabarti, R ^a   Seshagiri Rao, C ^a   Dileep Kumar, T ^a   Rajagopalan, R ^a  

^a DR REDDY S RESEARCH FOUNDATION   (India)

Author keywords

Animal models; Anti inflammatory; Biological activity; Insulin sensitiser; Thiazolidinedione

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; [6 (2 FLUOROBENZYLOXY) 2 NAPHTHYL]THIAZOLIDINE 2,4 DIONE; ANTIINFLAMMATORY AGENT; DRUG METABOLITE; NABUMETONE; NETOGLITAZONE; ORAL ANTIDIABETIC AGENT; TROGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; INFLAMMATORY DISEASE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PAW EDEMA; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOOD GLUCOSE; BUTANONES; CHROMANS; EDEMA; FEMALE; HYPOGLYCEMIC AGENTS; MALE; MICE; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIAZOLIDINEDIONES;

ANIMALIA;

EID: 18544403720     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00485-5     Document Type: Article

References (18)

1. 1. Many such examples are known in literature. To cite a few, Acedapsone (antimalarial and antibacterial), Acefylline (diuretic, cardiotonic and bronchodilator), Beclomethasone (antiallergic, antiasthmatic and antiinflammatory), Benactyzine (antidepressant and anticholinergic), Xylazine (sedative, analgesic and muscle relaxant), Zileuton (antiasthmatic and anti-inflammatory), etc.
2. 2. Das, U.N., J. Assoc.Physicians India, 1993, 41, 213
3. 3. Drummer, O.H., Kotsos, A., McIntyre, I.M., J. Anal. Toxicol., 1993, 17, 225.
4. 4. Drug Data Report, 1996, 18, 721.
5. 5. Harrison, I.T., Lewis, B., Nelson, P., Rooks, W., Roszkowski, A., Tomolonis, A., Fried, J.H., J. Med. Chem., 1970, 13, 203.
6. 6. Drug Data Report, 1997, 19, 374.
7. 7. Drug Data Report, 1994, 16, 791.
8. 8. Prabhakar, C., Bakki Reddy, G., Maheedhara Reddy, Ch., Nageshwar, D., Sivalakshmi Devi, A., Moses babu, J., Vyas, K., Sarma, M.R., Om Reddy, G., Manuscript under preparation.
9. 9. Nan, Z-S., Zhongguo Yiyao Gongye Zazhi, 1994, 25, 133.
10. 10. Organic Synthesis, 1955, 3, 14; Ibid., 1943, 2, 8.
11. 10. Organic Synthesis, 1955, 3, 14; Ibid., 1943, 2, 8.
12. 11. Horikoshi, H., Yoshioka, T., Kawasaki, T., Nakamura, K., Matsunuma, N., Yamaguchi, K., Sasahara, K., Annu. Rep. Sankyo Res. Lab., 1994, 46, 1.
13. +).
14. 13. Yoshioka, T., Fujita, T., Kanai, T., Aizawa, Y., Kurumada, T., Hasegawa, K., Horikoshi, H., J. Med. Chem., 1989, 32, 421.
15. 14. Anthony, W.L., Carl, J.R., US Patent 4,061,779.
16. 15. Ueno, H., Oe, T., Suehiro, I. and Nakamura, F., US Patent 5,594,016
17. 16.Winter, C.A., Risley, E.A. and Nuss, G.W., Proc. Soc. Exp. Biol., 1962, 111, 544.
18. 17. Lohray, B.B., Bhushan, V., Bheema Rao, P., Madhavan, G.R., Murali, N., Narasimha Rao, K., Anantha Reddy, K., Rajesh, B.M., Ganapathy Reddy, P., Chakrabarti, R., Rajagopalan, R., Biorg. Med. Chem. Lett, 1997, 7, 785.