Evaluation of antiprotozoal and plasmodial enoyl-ACP reductase inhibition potential of Turkish medicinal plants

Phytotherapy Research

Volumn 19, Issue 2, 2005, Pages 162-166

  Tasdemir, D ^a   Brun, R ^b   Perozzo, R ^c   Donmez A A ^d  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c ETH ZURICH   (Switzerland)

^d HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Leishmania donovani; Plasmodial enoyl ACP reductase (FabI); Plasmodium falciparum; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Turkish plants

Indexed keywords

ARTEMISIN; ASPERULA NITIDA EXTRACT; BENZNIDAZOLE; ENOYL ACYL CARRIER PROTEIN REDUCTASE; MELARSOPROL; METHYL CHLORIDE; MILTEFOSINE; MORINA PERSICA EXTRACT; OXIDOREDUCTASE; PHLOMIS KURDICA EXTRACT; PHLOMIS LEUCOPHRACTA EXTRACT; PLANT EXTRACT; PODOPHYLLOTOXIN; POLYPHENOL DERIVATIVE; PUTORIA CALABRICA EXTRACT; RHODODENDRON LIGUSTROIDES EXTRACT; RHODODENDRON LUTEUM EXTRACT; RHODODENDRON SMIRNOVII EXTRACT; RHODODENDRON UNGERNII EXTRACT; SCROPHULARIA CRYPTOPHILA EXTRACT; UNCLASSIFIED DRUG; WATER; WENDLANDIA LIGUSTROIDES EXTRACT;

ANIMAL CELL; ANTIMALARIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; ASPERULA NITIDA; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG POTENCY; DRUG SCREENING; DRUG SOLUBILITY; ENZYME INHIBITION; FATTY ACID SYNTHESIS; IC 50; LEISHMANIA DONOVANI; MEDICINAL PLANT; MORINA PERSICA; NONHUMAN; PHLOMIS; PHLOMIS KURDICA; PHLOMIS LEUCOPHRACTA; PHLOMIS LEUKOPHRACTA; PLANT LEAF; PLANT ROOT; PLASMODIUM FALCIPARUM; PUTORIA CALABRICA; RAT; RHODODENDRON; RHODODENDRON LUTEUM; RHODODENDRON SMIRNOVII; RHODODENDRON UNGERNII; SCROPHULARIA CRYPTOPHILA; SCROPHULARIACEAE; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TURKEY (REPUBLIC); WENDLANDIA LIGUSTROIDES;

ANIMALS; ANTIMALARIALS; ANTIPROTOZOAL AGENTS; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); HUMANS; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MALARIA, FALCIPARUM; MEDICINE, TRADITIONAL; OXIDOREDUCTASES; PARASITIC SENSITIVITY TESTS; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; PLANT ROOTS; PLANTS, MEDICINAL; PLASMODIUM FALCIPARUM; TRYPANOSOMA; TRYPANOSOMIASIS; TURKEY;

ASPERULA; LEISHMANIA DONOVANI; PHLOMIS; PLASMODIUM FALCIPARUM; PUTORIA CALABRICA; RHODODENDRON; RHODODENDRON LUTEUM; SCROPHULARIA; TRYPANOSOMA; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI; WENDLANDIA;

EID: 18444412526     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1648     Document Type: Article

References (14)

1. Baytop T. 1984. Therapy with Plants in Turkey, in the Past and the Present. Istanbul University Publications: Istanbul.
2. Çalis I, Gross GA, Sticher O. 1987. Phenylpropanoid glycosides isolated from Scrophularia scopolii. Phytochemistry 26: 2057-2061.
3. Çalis I, Heilmann J, Tasdemir D, Ireland CM, Sticher O. 2001. Flavonoid, iridoid and lignan glycosides from Putoria calabrica. J Nat Prod 66: 961-964.
4. Çalis I, Tasdemir D, Ireland CM, Sticher O. 2002. Lucidin type anthraquinone glycosides from Putoria calabrica. Chem Pharm Bull 50: 701-702.
5. Harwood J. 1996. Recent advances in the biosynthesis of plant fatty acids. Biochim Biophys Acta 1301: 7-56.
6. Katagiri M, Ohtani K, Kasai R, Yamasaki K, Yang CR, Tanaka O. 1994. Diterpenoid glycosyl esters from Phlomis younghusbandii and P. medicinalis roots. Phytochemistry 35: 439-442.
7. Kupchan SM, Britton RW, Ziegler MF, Sigel CW. 1973. Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica. J Org Chem 38: 178-179.
8. Perozzo R, Fidock DA, Kuo M, et al. 2002. Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase. J Biol Chem 277: 13106-13114.
9. Räz B, Iten M, Grether-Bühler Y, Kaminsky R, Brun R. 1997. The Alamar blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro. Acta Trop 68: 139-147.
10. Sperandeo NR, Brun R. 2003. Synthesis and biological evaluation of pyrazolylnaphthoquinones as new potential antiprotozoal and cytotoxic agents. ChemBioChem 4: 69-72.
11. Su B-N, Takaishi Y. 1999a. Morinins H-K, four novel phenyl-propanol ester lipid metabolites from Morina chinensis. J Nat Prod 62: 1325-1327.
12. Su B-N, Takaishi Y, Kusumi T. 1999b. Morinols A-L, twelve novel sesquineolignans and neolignans with a new carbon skeleton from Morina chinensis. Tetrahedron 55: 14571-14586.
13. Tasdemir D. 1997. Phytochemical and Biological Investigations of Turkish Leonurus Species, Emphasizing on the Diterpenoids of Leonurus persicus. PhD Thesis, ETH-Zurich, Diss. no. 12368.
14. Waller RF, Keeling PJ, Donald RG, et al. 1998. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum. Proc Natl Acad Sci USA 95: 12352-12357.