Gonadal function of young patients with beta-thalassemia following bone marrow transplantation

Journal of Pediatric Endocrinology and Metabolism

Volumn 18, Issue 5, 2005, Pages 477-483

  Vlachopapadopoulou, Elpis ^a   Kitra, V ^b   Peristeri, J ^b   Goussetis, E ^b   Karachaliou, F ^a   Petropoulos, D ^b   Fotinou, A ^a   Michalacos, S ^a   Graphakos, S ^b  

^a P AND A KYRIAKOU CHILDREN S HOSPITAL   (Greece)

^b AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

Author keywords

Adverse effects; Bone marrow transplantation; Gonadal function; Late effects; Thalassemia

Indexed keywords

ESTRADIOL; FOLLITROPIN; GONADOTROPIN; LUTEINIZING HORMONE; TESTOSTERONE;

ADOLESCENCE; ADOLESCENT; ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; AMENORRHEA; ARTICLE; BETA THALASSEMIA; BREAST DEVELOPMENT; CHILD; CHILDHOOD; CLINICAL ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; GONAD FUNCTION; GONADOTROPIN BLOOD LEVEL; HAIR GROWTH; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; MALE; MEDICAL DOCUMENTATION; MENARCHE; MENSTRUATION; PATIENT COUNSELING; PREPUBERTY; PUBERTY; SENSITIVITY ANALYSIS; SEX DIFFERENCE; TESTIS SIZE; TESTOSTERONE BLOOD LEVEL;

EID: 18444408111     PISSN: 0334018X     EISSN: None     Source Type: Journal    
DOI: 10.1515/JPEM.2005.18.5.477     Document Type: Article

References (22)

1. Olivieri NF, Nathan DG, MacMillan JH, Wayne AS, Liu PP, McGee A, Martin M, Koren G, Cohen AR. Survival in medically treated patients with homozygous beta-thalassemia. N Engl J Med 1994; 331: 574-578.
2. Masala A, Meloni T, Gallisai D, Alagna S, Rovasio PP, Rassu S, Milia AF. Endocrine functioning in multi-transfused prepubertal patients with homozygous beta-thalassemia. J Clin Endocrinol Metab 1984; 58: 667-670.
3. Giardini C. Treatment of beta-thalassemia. Curr Opin Hematol 1997; 4: 79-87.
4. Goussetis E, Peristeri J, Kitra V, Kattamis A, Petropoulos D, Papassotiriou I, Graphakos S. Combined umbilical cord blood and bone marrow transplantation in the treatment of beta-thalassemia major. Pediatr Hematol Oncol 2000; 17: 307-314.
5. Peristeri J, Kitra V, Goussetis E, Petropoulos D, Theodosaki M, Kattamis A, Graphakos S. Haematopoietic stem cell transplantation for the management of haemoglobinopathies in Greek patients. Transfus Sci 2000; 23: 263-264.
6. Thomas ED, Buckner CD, Sanders JE, Papayannopoulou T, Borgna-Pignatti C, De Stefano P, Sullivan KM, Clift RA, Storb R. Marrow transplantation for thalassaemia. Lancet 1982; ii: 227-229.
7. Howell SJ, Shalet SM. Testicular function following chemotherapy. Hum Reprod Update 2001; 7: 363-369.
8. Kyriacou C, Kottaridis PD, Eliahoo J, McKeag N, Bomford J, McGarrigle HH, Linch DC, Mackinnon S, Chatterjee R. Germ cell damage and Leydig cell insufficiency in recipients of nonmyeloablative transplantation for haematological malignancies. Bone Marrow Transplant 2003; 31: 45-50.
9. Salooja N, Szydlo RM, Socie G, Rio B, Chatterjee R, Ljungman P, Van Lint MT, Powles R, Jackson G, Hinterberger-Fischer M, Kolb HJ, Apperley JF, Late Effects Working Party of the European Group for Blood and Marrow Transplantation. Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey. Lancet 2001; 358: 271-276.
10. Tauchmanovà L, Selleri C, Rosa GD, Pagano L, Orio F, Lombardi G, Rotoli B, Colao A. High prevalence of endocrine dysfunction in long-term survivors after allogeneic bone marrow transplantation for hematologic diseases. Cancer 2002; 95: 1076-1084.
11. Byrne J, Mulvihill JJ, Myers MH, Connelly RR, Naughton MD, Krauss MR, Steinhorn SC, Hassinger DD, Austin DF, Bragg K, et al. Effects of treatment on fertility in long-term survivors of childhood or adolescent cancer. N Engl J Med 1987; 317: 1315-1321.
12. Shalet SM, Didi M, Ogilvy-Stuart AL, Schulga J, Donaldson MD. Growth and endocrine function after bone marrow transplantation. Clin Endocrinol (Oxf) 1995; 42: 333-339.
13. Lucarelli G, Galimberti M, Polchi P, Angelucci E, Baronciani D, Giardini C, Politi P, Durazzi SM, Muretto P, Albertini F. Bone marrow transplantation in patients with thalassemia. N Engl J Med 1990; 322: 417-421.
14. Grigg AP, McLachlan R, Zaja J, Szer J. Reproductive status in long-term bone marrow transplant survivors receiving busulfan-cyclophosphamide (120 mg/kg). Bone Marrow Transplant 2000; 26: 1089-1095.
15. De Sanctis V, Galimberti M, Lucarelli G, Angelucci E, Ughi M, Baronciani D, Polchi P, Giardini C, Bagni B, Vullo C. Pubertal development in thalassaemic patients after allogenic bone marrow transplantation. Eur J Pediatr 1993; 152: 993-997.
16. De Sanctis V. Growth and puberty and its management in thalassemia. Horm Res 2002; 58 (Suppl 1): 72-79.
17. Tolis GJ, Vlachopapadopoulou E, Karydis I. Reproductive health in patients with beta-thalassemia. Curr Opin Pediatr 1996; 8: 406-410.
18. Watson AR, Rance CP, Bain J. Long term effects of cyclophospamide on testicular function. Br Med J 1985; 291: 1457-1460.
19. Sklar C, Boulad F, Small T, Keman N. Endocrine complications of pediatric stem cell transplantation. Front Biosci 2001; 6: G17-G22.
20. Thibaud E, Rodriguez-Macias K, Trivin C, Esperou H, Michon J, Brauner R. Ovarian function after bone marrow transplantation during childhood. Bone Marrow Transplant 1998; 21: 287-290.
21. Papadakis V, Vlachopapadopoulou E, Van Syckle K, Ganshaw L, Kalmanti M, Tan C, Sklar C. Gonadal function in young patients successfully treated for Hodgkin disease. Med Pediatr Oncol 1999; 32: 366-372.
22. Davies MC, Hall ML, Jacobs HS. Bone mineral loss in young women with amenorrhoea. Br Med J 1990; 301: 790-793.