Detection of a novel variant human hemoglobin by electrospray ionization mass spectrometry

Biochemical and Biophysical Research Communications

Volumn 292, Issue 4, 2002, Pages 1044-1047

  Troxler, Heinz ^a   Neuheiser, Frank ^a   Kleinert, Peter ^a   Kuster, Thomas ^a   Heizmann, Claus W ^a   Sack, Ragna ^a   Hunziker, Peter ^a   Neuhaus, Thomas J ^a   Schmid, Marlis ^a   Frischknecht, Hannes ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Electrospray ionization mass spectrometry; Hemoglobin analysis; Hemoglobin variant

Indexed keywords

ASPARAGINE; HEMOGLOBIN DERIVATIVE; HEMOGLOBIN ZURICH HOTTINGEN; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CASE REPORT; CONTROLLED STUDY; DNA DETERMINATION; HUMAN; HYPERSPLENISM; ION EXCHANGE CHROMATOGRAPHY; ISOELECTRIC FOCUSING; KIDNEY FAILURE; KIDNEY POLYCYSTIC DISEASE; MALE; MASS; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; SCHOOL CHILD;

EID: 18444392397     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6762     Document Type: Article

References (13)

1. Laboratory investigation of hemoglobinopathies and thalassemias: Review and update
2. JMS Letters
3. Potential of electrospray mass spectrometry for quantifying glycohemoglobin
4. Mass spectrometry in the characterisation of variant hemoglobins
5. High-performance liquid chromatographic separation of human haemoglobins: Simultaneous quantification of foetal and glycated haemoglobins
6. Isoelectric focusing of human hemoglobin: Its application to screening, to the characterization of 70 variants, and to the study of modified fractions of normal hemoglobins
7. Separation of normal and abnormal hemoglobin chains by reversed-phase high-performance liquid chromatography
8. Design and construction of a nanoelectrospray ion source for a triple quadrupole mass spectrometer
9. 2+-binding properties of human recombinant α-parvalbumin and nine mutant proteins
10. Rapid detection of point mutations and polymorphisms of the alpha-globin genes by DGGE and SSCA
11. Electrospray mass spectrometry: An efficient method to detect silent hemoglobin variants causing erythrocytosis