Angiotensin II is bound to both receptors AT1 and AT2, parallel to the transmembrane domains and in an extended form

Canadian Journal of Physiology and Pharmacology

Volumn 80, Issue 5, 2002, Pages 418-425

  Deraet M ^a   Rihakova, L ^a   Boucard, A ^a   Perodin J ^a   Sauve S ^a   Mathieu, A P ^a   Guillemette, G ^a   Leduc, R ^a   Lavigne, P ^a   Escher, E ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Angiotensin receptors; Contact points; Molecular modelling; Photolabelling method

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; RHODOPSIN;

AMINO TERMINAL SEQUENCE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONFERENCE PAPER; MOLECULAR MODEL; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY;

AMINO ACID SEQUENCE; ANGIOTENSIN II; ANIMALS; CATTLE; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, ANGIOTENSIN;

EID: 18444381154     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y02-060     Document Type: Conference Paper

References (33)

1. Structure and function of receptors coupled to G proteins
2. 1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII
3. Sar1-p-benzoylphenylalanine-angiotensin, a new photoaffinity probe for selective of the type 2 angiotensin receptor
4. 1 receptor as a ligand contact point: Receptor-bound angiotensin II adopts an extended structure
5. Angiotensin II receptor and signal transduction mechanisms
6. Structure and energetics of ligand binding to proteins: E. coli dihydrofolate reductase - Trimethorpin, a drug-receptor system
7. International union of pharmacology. XXIII. The angiotensin II receptors
8. Identification and sequence of a binding site peptide of the beta-adrenergic receptor
9. Benzophenone photophores in biochemistry
10. Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice
11. Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
12. A review of mutagenesis studies of angiotensin II type 1 receptor, the three-dimensional receptor model in search of the agonist and antagonist binding site and the hypothesis of a receptor activation mechanism
13. Proposals for the angiotensin II receptor-bound conformation by comparative computer modeling of AII and cyclic analogs
14. 1 adenosine receptor with an antagonist photoaffinity probe
15. 1) with photosensitive analogs of angiotensin II
16. Mapping peptide-binding domains of the substance P (NK-1) receptor from P388D1 cells with photolabile agonists
17. Photoaffinity labeling of mutant neurokinin-1 receptors reveals additional structural features of the substance P/NK-1 receptor complex
18. Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors
19. 2 receptor searching for signal-transduction pathways and physiological function
20. 3D model for TM region of the AT-1 receptor in complex with angiotensin II independently validated by site-directed mutagenesis data
21. 1 interaction and signal transduction
22. Crystal structure of rhodopsin: A G protein-coupled receptor
23. Methionine proximity assay, a novel method for exploring peptide ligand - Receptor interactions
24. Locating ligand-binding sites in 7TM receptors by protein engineering
25. Is there a "lock" for all agonist "keys" in 7TM receptors
26. 2 receptor with photolabile angiotensin analogs
27. Angiotensin II type 2 receptor-mediated apoptosis of cultured neurons from newborn rat brain
28. Structure and function of G protein-coupled receptors
29. Tools for the identification of receptor dimers: Synthesis and biological evaluation of on-resin dimerized, photosensitive analogues of angiotensin II
30. Angiotensin II receptors and angiotensin II receptor antagonists
31. 2 receptor subtype