Abnormal renal structural alterations during the development of diabetes mellitus in Otsuka Long-Evans Tokushima Fatty rats

Acta Physiologica Scandinavica

Volumn 184, Issue 1, 2005, Pages 73-81

  Koike, T ^a   Tomoda, F ^a   Kinuno, H ^a   Inoue, H ^a   Takata, M ^b  

^a UNIVERSITY OF TOYAMA   (Japan)

^b Toyama Teishin Hospital   (Japan)

Author keywords

Diabetic nephropathy; Flow pressure relationship; Glomerular hypertension; Otsuka Long Evans Tokushima Fatty rats; Renal vascular structure; Vasodilated perfused kidney

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY DIAMETER; ARTERY WALL; CONFERENCE PAPER; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE COURSE; GLOMERULOPATHY; GLOMERULUS FILTRATION RATE; HISTOPATHOLOGY; KIDNEY BLOOD FLOW; KIDNEY STRUCTURE; KIDNEY VASCULAR RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; RENOVASCULAR HYPERTENSION; THICKNESS;

ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; GLOMERULAR FILTRATION RATE; KIDNEY; MALE; ORGAN SIZE; PROTEINURIA; RATS; RATS, INBRED OLETF; VASCULAR RESISTANCE; VASODILATION;

EID: 18444376167     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-201X.2005.01418.x     Document Type: Conference Paper

References (40)

1. Østerby, R., Bangstad, H.J., Nyberg, G., Walker, J.D. & Viberti, G. 1995. A quantitative ultrastructural study of juxtaglomerular arterioles in IDDM patients with micro- and normoalbuminuria. Diabetologia 38, 1320-1327.
2. Anderson, S. & Brenner, B.M. 1988. Role of altered capillary hemodynamics in the initiation and progression of diabetic microangiopathy. J Diabet Complications 2, 59-61.
3. Arendshorst, W.J. & Beierwaltes, W.H. 1979. Renal and nephron hemodynamics in spontaneously hypertensive rats. Am J Physiol 236, F246-F251.
4. Azar, S., Limas, C., Iwai, J. & Weller, D. 1979. Single-nephron dynamics during high sodium intake and early hypertension in Dahl rats. Jpn Heart J 20(Suppl. 1), S138-S140.
5. Bank, N., Lahorra, M.A., Aynedjian, H.S. & Schlondorff, D. 1988. Vasoregulatory hormones and the hyperfiltration of diabetes. Am J Physiol 254, F202-F209.
6. Bergström, G., Johansson, I., Stevenson, K.M., Kett, M.M. & Anderson, W.P. 1998. Perindopril treatment affects both preglomerular renal vascular lumen dimensions and in vivo responsiveness to vasoconstrictors in spontaneously hypertensive rats. Hypertension 31, 1007-1013.
7. Copper, M.E. 1998. Pathogenesis, prevention and treatment of diabetic nephropathy. Lancet 352, 213-219.
8. Crijns, F.R., Wolffenbuttel, B.H., De Mey, J.G. & Struijker Boudier, H.A. 1999. Mechanical properties of mesenteric arteries in diabetic rats: consequences of outward remodeling. Am J Physiol 276, H1672-H1677.
9. Davidson, W.D. & Sackner, M.A. 1963. Simplification of the anthrone method for the determination of inulin in clearance studies. J Lab Clin Med 62, 351-356.
10. Dworkin, L.D., Hostetter, T.H., Rennke, H.G. & Brenner, B.M. 1984. Hemodynamic basis for glomerular injury in rats with desoxycorticosterone-salt hypertension. J Clin Invest 73, 1448-1461.
11. Folkow, B. 1982. Physiological aspects of primary hypertension. Physiol Rev 62, 347-504.
12. Folkow, B. 1995. Hypertensive structural changes in systemic precapillary resistance vessels: how important are they for in vivo haemodynamics? J Hypertens 13, 1546-1559.
13. Fukuzawa, Y., Watanabe, Y., Inaguma, D. & Hotta, N. 1996. Evaluation of glomerular lesion and abnormal urinary findings in OLETF rats resulting from a long-term diabetic state. J Lab Clin Med 128, 568-578.
14. Gibbons, G.H. & Dzau, V.J. 1994. The emerging concept of vascular remodeling. N Engl J Med 330, 1431-1438.
15. Göthberg, G. & Folkow, B. 1983. Age-dependent alterations in the structurally determined vascular resistance, pre- to postglomerular resistance ratio and glomerular filtration capacity in kidneys, as studied in aging normotensive rats and spontaneously hypertensive rats. Acta Physiol Scand 177, 547-555.
16. Göthberg, G., Hallbäck-Nordlander, M., Karlström, G., Ricksten, S.E. & Folkow, B. 1983. Structurally based changes of renal vascular reactivity in spontaneously hypertensive and two-kidney, one-clip renal hypertensive rats, as compared with kidneys from uninephrectomized and intact normotensive rats. Acta Physiol Scand 118, 61-67.
17. Hampton, J.A., Bernardo, D.A., Khan, N.A. et al. 1989. Morphometric evaluation of the renal arterial system of Dahl salt-sensitive and salt-resistant rats on a high salt diet. II. Interlobular arteries and intralobular arterioles. Lab Invest 60, 839-846.
18. Hirashima, T., Kawano, K., Mori, S., Matsumoto, K. & Natori, T. 1995. A diabetogenic gene (ODB-1) assigned to the X-chromosome in OLETF rats. Diabetes Res Clin Pract 27, 91-96.
19. Hirashima, T., Kawano, K., Mori, S. & Natori, T. 1996. A diabetogenic gene, ODB2, identified on chromosome 14 of the OLETF rat and its synergistic action with ODB1. Biochem Biophys Res Commun 224, 420-425.
20. Ishida, K., Mizuno, A., Min, Z., Sano, T. & Shima, K. 1995. Which is the primary etiologic event in Otsuka Long-Evans Tokushima Fatty rats, a model of spontaneous non-insulin-dependent diabetes mellitus, insulin resistance, or impaired insulin secretion? Metabolism 44, 940-945.
21. Jaffa, A.A., Rust, P.F. & Mayfield, R.K. 1995. Kinin, a mediator of diabetes-induced glomerular hyperfiltration. Diabetes 44, 156-160.
22. Kawano, K., Hirashima, T., Mori, S., Saitoh, Y., Kurosumi, M. & Natori, T. 1992. Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41, 1422-1428.
23. Kett, M.M., Alcorn, D., Bertram, J.F. & Anderson, W.P. 1995. Enalapril does not prevent renal arterial hypertrophy in spontaneously hypertensive rats. Hypertension 25, 335-342.
24. Kim, S., Wanibuchi, H., Hamaguchi, A., Miura, K., Yamanaka, S. & Iwao, H. 1997. Angiotensin blockade improves cardiac and renal complications of type II diabetic rats. Hypertension 30, 1054-1061.
25. Komers, R. & Anderson, S. 2003. Paradoxes of nitric oxide in the diabetic kidney. Am J Physiol 284, F1121-F1137.
26. Korner, P.I. & Angus, J.A. 1992. Structural determinants of vascular resistance properties in hypertension: haemodynamic and model analysis. J Vasc Res 29, 293-312.
27. Mulvany, M.J. 1999. Vascular remodeling of resistance vessels: can we define this? Cardiovasc Res 41, 9-13.
28. Parving, H.H., Østerby, R. & Ritz, E. 2000. Diabetic nephropathy. In: B.M. Brenner (ed.) The Kidney, pp. 1731-1773. WB Saunders Company, Philadelphia.
29. Schwab, S.J., Christensen, R.L., Dougherty, K. & Klahr, S. 1987. Quantitation of proteinuria by the use of protein-to-creatinine ratios in single urine samples. Arch Intern Med 147, 943-944.
30. Smeda, J.S., Lee, R.M. & Forrest, J.B. 1988. Structural and reactivity alterations of the renal vasculature of spontaneously hypertensive rats prior to and during established hypertension. Circ Res 63, 518-533.
31. Striker, G.E., Agodoa, L.L., Held, P., Doi, T., Conti, F. & Striker, L.J. 1991. Kidney disease of diabetes mellitus (diabetic nephropathy): perspectives in the United States. J Diabet Complications 5, 51-52.
32. Taal, M.W. & Brenner, B.M. 2000. Renoprotective benefits of RAS inhibition: from ACEI to angiotensin II antagonists. Kidney Int 57, 1803-1817.
33. Tomoda, F., Bergström, G., Evans, R.G. & Anderson, W.P. 1997. Evidence for decreased structurally determined preglomerular resistance in the young spontaneously hypertensive rat after 4 weeks of renal denervation. J Hypertens 15, 1187-1195.
34. Tomoda, F., Takata, M., Kinuno, H., Tomita, S., Yasumoto, K. & Inoue, H. 2000. Renal structural properties in prehypertensive Dahl salt-sensitive rats. Hypertension 36, 68-72.
35. Uriu, K., Kaizu, K., Qie, Y.L. et al. 1999a. Renal hemodynamics in Otsuka Long-Evans Tokushima fatty rat, a model rat of spontaneous non-insulin- dependent diabetes mellitus with obesity. J Lab Clin Med 134, 483-491.
36. Uriu, K., Kaizu, K., Qie, Y.L., Kai, K. & Eto, S. 1999b. Effect of acute thromboxane A2 inhibition on the renal hemodynamics in a spontaneously non-insulin-dependent diabetic rat, Otsuka Long-Evans Tokushima Fatty rat. J Diabet Complications 13, 182-186.
37. Vallon, V., Blantz, R.C. & Thomson, S. 1995. Homeostatic efficiency of tubuloglomerular feedback is reduced in established diabetes mellitus in rats. Am J Physiol 269, F876-F883.
38. Vranes, D., Dilley, R.J. & Cooper, M.E. 1995. Vascular changes in the diabetic kidney: effects of ACE inhibition. J Diabet Complications 9, 296-300.
39. Yagi, K., Kim, S., Wanibuchi, H., Yamashita, T., Yamamura, Y. & Iwao, H. 1997. Characteristics of diabetes, blood pressure, and cardiac and renal complications in Otsuka Long-Evans Tokushima Fatty rats. Hypertension 29, 728-735.
40. Zatz, R., Dunn, B.R., Meyer, T.W., Anderson, S., Rennke, H.G. & Brenner, B.M. 1986. Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension. J Clin Invest 77, 1925-1930.