Primary local orbital amyloidosis: Biochemical identification of the immunoglobulin light chain κIII subtype in a small formalin fixed, paraffin wax embedded tissue sample

Journal of Clinical Pathology

Volumn 58, Issue 5, 2005, Pages 539-542

  Kaplan, B ^a,b   Martin, B M ^c   Cohen, H I ^d   Manaster, J ^d   Kassif, Y ^d   Rehany, U ^d   Livneh, A ^b  

^a HELLER INSTITUTE OF MEDICAL RESEARCH   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^d WESTERN GALILEE HOSPITAL   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PROTEIN; FORMALDEHYDE; FORMIC ACID; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN KAPPA CHAIN III; PARAFFIN; UNCLASSIFIED DRUG;

ADULT; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; AMYLOIDOSIS; ARTICLE; CASE REPORT; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; DISEASE CLASSIFICATION; ELECTROPHORESIS; EXTRACTION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; ORBIT DISEASE; PRIMARY LOCAL ORBITAL AMYLOIDOSIS; PRIORITY JOURNAL; WESTERN BLOTTING;

ADULT; AMINO ACID SEQUENCE; AMYLOID; AMYLOIDOSIS; EYE PROTEINS; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOHISTOCHEMISTRY; ORBITAL DISEASES; PARAFFIN EMBEDDING;

EID: 18444374432     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2004.022517     Document Type: Article

References (20)

1. Gean-Marton AD, Kirsh CFE, Vezina LG, et al. Focal amyloidosis of the head and neck: evaluation with CT and MR imaging. Radiology 1991;181:521-5.
2. Knowles DM II, Jacobiec FA, Rosen M, et al. Amyloidosis of the orbit and adnexae. Surv Ophthalmol 1975;9:367-84.
3. Lucas DR, Knox F, Davies S. Apparent monoclonal origin of lymphocytes and plasma cells infiltrating ocular adnexal amyloid deposits: report of two cases, Br J Ophthalmol 1982;66:600-6.
4. Conlon MR, Chapman WB, Burt WL, et al. Primary localized amyloidosis of lacrimal glands. Ophthalmology 1991;98:1556-9.
5. Murdoch IE, Sullivan TJ, Moseley I, et al. Primary localized amyloidosis of the orbit. Br J Ophthalmol 1996;80:1083-6.
6. Pasternak S, White VA, Gascoyne RD, et al. Monoclonal origin of localized orbital amyloidosis detected by molecular analysis. Br J Ophthalmol 1996;80:1013-17.
7. Taban M, Piva A, See RF, et al. Orbital amyloidosis. Ophthal Plast Reconstr Surg 2004;20:162-5.
8. Tan SY, Murdoch IE, Sullivan TJ, et al. Primary localized orbital amyloidosis composed of immunoglobulin gamma heavy chain CH3 domain. Clin Sci 1994;87:487-91.
9. Dithmar S, Linke RP, Kolling G, et al. Ptosis from localized A-λ-amyloid deposits in the levator palpebrae muscle. Ophthalmology 2004;111:1043-7.
10. Olsen KE, Sangren O, Sletten K, et al. Primary localized amyloidosis of the eyelid: two cases of immunoglobulin light chain-derived proteins, subtype λV respectively λVI. Clin Exp Immunol 1996;106:362-6.
11. Gallo GR, Feiner HD, Chuba JV, et al. Characterization of tissue amyloid by immunofluorescence microscopy. Clin Immunol Immunopathol 1986;39:479-90.
12. Kaplan B, Martin BM, Livneh A, et al. Biochemical subtyping of amyloid in formalin-fixed tissue samples confirms and supplements immunohistological data. Am J Clin Pathol 2004;121:794-800.
13. Kaplan B, Yakar S, Kumar A, et al. Immunochemical characterization of amyloid in diagnostic biopsy tissues. Amyloid 1997;4:80-6.
14. Kaplan B, Vidal R, Kumar A, et al. Immunochemical microanalysis of amyloid proteins in fine-needle aspirates of abdominal fat. Am J Clin Pathol 1999;112:403-7.
15. Kaplan B, Cojocaru M, Unsworth E, et al. Search for peptidic "middle molecules" in uremic sera: isolation and chemical identification of fibrinogen fragments. J Chromatogr B Analyt Technol Biomed Life Sci 2003;796:141-53.
16. Kaplan B, Shtrasburg, Pras M. Micropurification techniques in analysis of amyloid proteins. J Clin Pathol 2003;56:86-9.
17. Levine MR, Buckman G. Primary localized orbital amyloidosis. Ann Ophthalmol 1986;18:281-6.
18. Jakulis R, Dawson RR, Wang SE, et al. Fine needle aspiration diagnosis of orbital plasmacytoma with amyloidosis: a case report. Acta Cytol 1995;39:104-10.
19. Ando Y, Nakamura M, Kai H, et al. A novel localized amyloidosis associated with lactoferrin in cornea. Lab Invest 2002;82:757-65.
20. Kaplan B, Hrncic R, Murphy CL, et al. Microextraction and purification techniques applicable to the characterization of amyloid proteins in minute amounts of tissue. Methods Enzymol 1999;309:67-81.