Activation of leptin expression by an inhibitor of carnitine palmitoyltransferase-1

International Journal of Obesity

Volumn 28, Issue 4, 2004, Pages 649-651

  Wolkowicz, P ^a   Grenett, H ^a   Belousova, M ^b   Urthaler, F ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

2 tetradecylglycidic acid; Carnitine palmitoyltransferase 1; Epididymal fat pads; Leptin; Methyl palmoxirate; Rat

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE; ENZYME INHIBITOR; LEPTIN; MESSENGER RNA; PALMOXIRIC ACID;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EPIDIDYMIS; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; FATTY ACID OXIDATION; FEEDBACK SYSTEM; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; ENZYME INHIBITORS; EPIDIDYMIS; EPOXY COMPOUNDS; FATTY ACIDS; GENE EXPRESSION REGULATION; LEPTIN; MALE; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

ANIMALIA;

EID: 1842866961     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0802585     Document Type: Article

References (17)

1. Ahima RS, Flier JS. Leptin. Ann Rev Physiol 2000; 62: 413-437.
2. Vernon Rayner D, Trayhurn P. Regulation of leptin production: sympathetic nervous system interactions. J Mol Med 2001; 79: 8-20.
3. Levine AS, Billington CJ. Do circulating leptin concentrations reflect body adiposity of energy flux? Am J Clin Nutr 1998; 68: 761-762.
4. Minokoshi Y, Kim Y-B, Peroni OD, Fryer LGD, Muller C, Carling D, Kahn BB. Leptin stimulates fatty acid oxidation by activating AMP-activated protein kinase. Nature 2002; 415: 339-343.
5. Muoio DM, Dohm GL, Fiedorek FT, Tapscott EB, Coleman RA. Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 1997; 46: 1360-1363.
6. Shimabukuro M, Koyama K, Chen G, Wand M-Y, Trieu F, Lee Y, Newgard CB, Unger RH. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 1997; 94: 4637-4641.
7. Atkinson LL, Fischer MA, Lopaschuk GD. Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis. J Biol Chem 2002; 277: 29424-29430.
8. Worm D, Vinten J, Vaag A, Henriksen JE, Beck-Nielsen H. The nicotinic acid analogue acipomox increases plasma leptin and decreases fatty acid in type 2 diabetes patients. Eur J Endocrinol 2000; 143: 389-395.
9. Wang-Fisher Y-L, Han J, Guo W. Acipomox stimulates leptin production from isolated rat adipocytes. J Endocrinol 2002; 174: 267-272.
10. Kiorpes TC, Hoerr D, Ho W, Weaner LE, Inman MG, Tutwiler GF. Identification of 2-tetradecylglycidyl coenzyme A as the active form of methyl 2-tetradecylglycidate (methyl palmoxirate) and its characterization as an irreversible, active site-directed inhibitor of carnitine palmitoyltransferase A in isolated rat liver mitochondria. J Biol Chem 1984; 259: 9750-9755.
11. Wolkowicz P, Urthaler F, Forrest C, Shen H, Durand J, Wei C-C, Oparil S, Dell'Italia LJ. 2-Tetradecylglycidic acid, an inhibitor of carnitine palmitoyltransferase-1, induces myocardial hypertrophy via the AT1 receptor. J Mol Cell Cardiol 1999; 31: 1405-1412.
12. Grenett HE, Bounelis P, Fuller GM. Identification of a human cDNA with high homology to yeast omnipotent suppressor 45. Gene 1992; 110: 239-243.
13. Grenett HE, Wolkowicz PE, Benza RL, Tresnak JK, Wheeler CG, Booyse FM. Identification of a 251-bp fragment of the PAI-1 gene promoter that mediates the ethanol-induced suppression of PAI-1 expression. Alcohol: Clin Exp Res 2001; 25: 629-636.
14. Margetic S, Gazzola C, Pegg GG, Hill RA. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 2002; 26: 1407-1433.
15. Shimokawa T, Kumar MV, Lane MD. Effect of fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. Proc Natl Acad Sci USA 2002; 99: 66-71.
16. Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, Kuhajda FP. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 2000; 288: 2379-2781.
17. Martin RJ, Bird MI, Saggerson ED, Munday LA, Clark JB. Enzyme activities in regions of the hypothalamus. J Neurochem 1987; 48: 738-740.